2 hydroxy 4 2 hydroxyethoxy 2 methylpropiophenone

Manufactured by Maclin Biochemical Technology

Sourced in China

2-hydroxy-4′-(2-hydroxyethoxy)-2-methylpropiophenone is a chemical compound used in laboratory settings. It functions as a photoinitiator, a substance that initiates a photochemical reaction when exposed to light. This compound is commonly utilized in the production and curing of various polymer materials.

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Lab products found in correlation

Syringe pump, by Harvard Apparatus (1 mentions) Dimethyl silicone oil, by Maclin Biochemical Technology (1 mentions) Fe3o4, by Maclin Biochemical Technology (1 mentions)

2 protocols using 2 hydroxy 4 2 hydroxyethoxy 2 methylpropiophenone

Photocrosslinkable Gelatin Hydrogels

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(1) 300 mg of gelatin (glue strength: ∼250 g Bloom, Aladdin, China) was added into 7 mL of deionized (DI) water and then was stirred for 30 min at 40°C using magnetic stirrer until the gelatin was dissolved.

(2) 20 mg of photoinitiator (2-hydroxy-4′-(2-hydroxyethoxy)-2-methylpropiophenone) (Macklin, Shanghai, China) was added into 3 mL of DI water. Then mixed liquid was stirred for 10 min at 30°C using magnetic stirrer to obtain photoinitiator aqueous solution.

(3) The gelatin aqueous solution and the photoinitiator aqueous solution were mixed, and 0.1 mL of acid-base buffer was added.

(4) The Fe₃O₄ particles (20 nm) and LH were added into the mixed solution, and adjust the concentrations to 2.5% and 20 μM, respectively.

Jiang F., Zheng Q., Zhao Q., Qi Z., Wu D., Li W., Wu X, & Han C. (2024). Magnetic propelled hydrogel microrobots for actively enhancing the efficiency of lycorine hydrochloride to suppress colorectal cancer. Frontiers in Bioengineering and Biotechnology, 12, 1361617.

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Fabrication of Gelatin Microrobots

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Gelatin microparticles (microrobots) were synthesized in a multi-channel fluidic module based on the shear stress of two-phase flow (Figure 3A). 0.5 g of gelatin [Cas (9000–70–8), Aladdin, Shanghai, China] was first dissolved in 10 ml of deionized (DI) water. Then, an additional 2 ml of Fe₃O₄ (10–30 nm, 25% in H₂O, Macklin, Shanghai, China), 1 ml EPZ015666 (10 uM, Cat. No.: HY-12727, MedChemExpress, United States) stained by rhodamine (Macklin, Shanghai, China), and 10 mg 2-hydroxy-4′-(2-hydroxyethoxy)-2-methylpropiophenone (Macklin, Shanghai, China) were added. The mixed solution and dimethyl silicone oil (Macklin, Shanghai, China) were injected into microfluidic chips as sample flow (disperse phase) and sheath flow (continuous phase) using syringe pumps (Harvard Apparatus, United States), respectively. Gelatin microparticles were generated and then irradiated using UV light source. After 10 min of irradiation, the case-hardened gelatin microparticles were obtained, collected by centrifugation, and then washed thrice with DI water to remove oil and any other residue.

Mu H., Liu C., Zhang Q., Meng H., Yu S., Zeng K., Han J., Jin X., Shi S., Yu P., Li T., Xu J, & Hua Y. (2022). Magnetic-Driven Hydrogel Microrobots Selectively Enhance Synthetic Lethality in MTAP-Deleted Osteosarcoma. Frontiers in Bioengineering and Biotechnology, 10, 911455.

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