Biograph 6 hirez pet ct scanner

All participants underwent a PET scan with [¹¹C]UCB-J, a radioligand specific for SV2A^{31 (link),47 (link)}. Each subject had a CT scan for attenuation correction purposes 2 min prior to the injection of radiotracer. The study physician administered a microdose of [¹¹C]UCB-J (target activity approximately 300 MBq) via an intravenous cannula as a smooth bolus injection over 20 s. PET data were acquired for 90 min using a Biograph 6 HiRez PET-CT scanner (Siemens, Erlangen, Germany). Arterial blood was collected throughout the PET scan unilaterally via the radial artery to measure the arterial input function.

Following a low-dose computed tomography scan for attenuation and scatter correction, subjects received a microdose of [¹¹C]UCB-J (≤300 MBq) as a smooth bolus injection via an intravenous cannula for 20 seconds. A Biograph 6 HiRez PET-CT scanner (Siemens) was used to acquire PET data for 90 minutes.