Gmx1778

Manufactured by Selleck Chemicals

Sourced in Germany

The GMX1778 is a piece of laboratory equipment used for various chemical and scientific applications. It is designed to perform specific functions within the laboratory environment. The core function of the GMX1778 is to provide precise and reliable measurements or data collection related to the research or experiments being conducted.

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Lab products found in correlation

Doxycycline, by Selleck Chemicals (1 mentions) Carboplatin, by Selleck Chemicals (1 mentions) Cisplatin, by Selleck Chemicals (1 mentions) Rabbit polyclonal anti lamin b1, by Abcam (1 mentions) Mouse monoclonal anti β actin, by Merck Group (1 mentions) Cleaved caspase 3, by Cell Signaling Technology (1 mentions) Aldh1, by BD (1 mentions) Wzb117, by Merck Group (1 mentions) Nicotinic acid, by Merck Group (1 mentions) Stf 31, by Merck Group (1 mentions)

3 protocols using gmx1778

Synthesis and Preparation of 4-Cl-HIPP and GMX1778

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4-Cl-HIPP was synthesized as described previously (15 (link)) and prepared as a 50 mmol/L stock solution in 100 mmol/L NaHCO₃ (pH = 8.5) and stored at −20°C. GMX1778 (Selleckchem #S8117) was solubilized in DMSO as a 50 mmol/L stock solution and stored at −20°C. 100 mmol/L NaHCO₃ was used as the vehicle for all experiments.

Dcona M.M., Chougoni K.K., Dcona D.T., West J.L., Singh S.J., Ellis K.C, & Grossman S.R. (2023). Combined Targeting of NAD Biosynthesis and the NAD-dependent Transcription Factor C-terminal Binding Protein as a Promising Novel Therapy for Pancreatic Cancer. Cancer Research Communications, 3(10), 2003-2013.

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Immunoblotting Antibody and Compound Protocol

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The following antibodies were purchased from the indicated supplied and used for immunoblotting: Rabbit monoclonal anti-HMGA1 (Sigma, cat. no. 129153), rabbit polyclonal anti-NAMPT (Bethyl Laboratories, cat. no. A300–372A), mouse monoclonal anti-β-Actin (Sigma, cat. no. 2532), ALDH1 (BD laboratories, cat. no. 611195), rabbit polyclonal anti-Lamin B1 (Abcam, cat. no. ab65986), cleaved PARP1 (Promega, cat. no. G7341), cleaved caspase 3 (Cell Signaling, cat. no. 9662). The following compounds were purchased from the indicated suppliers and used at the indicated concentrations for in vitro studies: cisplatin (Selleck, cat. no. S1166), 250 nM; carboplatin (Selleck, cat. no. S1215), 500 nM; FK866 (Millipore, cat. no. 48–190-82), 1 nM; GMX1778 (Selleck, cat. no. S8117), 0.5 nM; NMN (Sigma, cat. no. N3501), 500 μM; and doxycycline (Selleck, cat. no. S4163), 1 μg/ml.

Nacarelli T., Fukumoto T., Zundell J.A., Fatkhutdinov N., Jean S., Cadungog M.G., Borowsky M.E, & Zhang R. (2019). NAMPT inhibition suppresses cancer stem-like cells associated with therapy-induced senescence in ovarian cancer. Cancer research, 80(4), 890-900.

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Characterization of Radiolabeled Metabolites

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Fasentin, WZB117, and STF-31 were from Merck Millipore. GMX1778 was obtained from Selleck Chemicals and nicotinic acid (NA) from Sigma. [¹⁸F]-fluoro-deoxyglucose ([¹⁸F]-FDG; in 0.9% sodium chloride) was kindly supplied by Advanced Accelerator Applications (Bonn, Germany).

Winter J., Kunze R., Veit N., Kuerpig S., Meisenheimer M., Kraus D., Glassmann A, & Probstmeier R. (2023). Targeting of Glucose Transport and the NAD Pathway in Neuroendocrine Tumor (NET) Cells Reveals New Treatment Options. Cancers, 15(5), 1415.

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