Male wildtype (C57Bl/10) and mdx (C57Bl/10ScSn-DMDmdx) mice were obtained from Jackson Laboratory (Bar Harbor, ME, USA) or bred locally from these mice, and were 3–6 months old at the time of the experimental protocols. Mice were initially anesthetized in an induction chamber using isoflurane, and then maintained by inhalation of 1.5% isoflurane mixed with oxygen at a flow rate of 125 ml/min for all surgical procedures. This anesthetic regimen was also used when torque and EMG measurements were made. Following the final contraction protocol, mice were euthanized with an overdose of sodium pentobarbital (150 mg/kg body mass). All animal procedures were in accordance with the standards set by the Institutional Animal Care and Use Committees at the University of Minnesota.
C57bl 10scsn dmdmdx
Manufactured by Jackson ImmunoResearch
Sourced in United States
C57Bl/10ScSn-DMDmdx is a laboratory mouse strain that carries a spontaneous mutation in the dystrophin gene, resulting in a model for Duchenne muscular dystrophy. This strain can be used for research purposes related to muscular dystrophy.
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10 protocols using c57bl 10scsn dmdmdx
1
Muscle Physiology in mdx Mice
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Longitudinal Muscle Sampling in mdx Mice
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Aging Mdx Mouse Model Study
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Adult male and female mdx mice (C57Bl/10ScSn-DMDmdx) and wild-type BL/10 mice (C57Bl/10ScSn) aged 2–6 months old were obtained from Jackson Labs (Bar Harbor, ME) and housed locally. The procedures used in this study were approved by the University of Minnesota’s Institutional Animal Care and Use Committee (IACUC).
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Muscular Dystrophy Mouse Model Study
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Urine Metabolite Analysis in DMD
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Mdx Mouse Breeding and Housing
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Animal use and experimentation for this study was approved by The Ohio State University (OSU) Institutional Animal Care and Use Committee and all experiments were performed in accordance with relevant ethical guidelines and regulations. Mdx mice were originally purchased from The Jackson Laboratory (C57BL/10 ScSn DMDmdx) and have been housed and bred in the animal facilities of OSU for 10 years. Myh6 cre and IKKβ flox mice were previously created55 (link),56 (link). Mice were kept on a 14:10 light-dark cycle with constant temperature and humidity and fed a standard diet. Male mice were used for these studies.
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Muscular Dystrophy Model Mice Protocol
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Control (C57BL/6) and mdx (C57BL/10 ScSn-Dmdmdx) mice were obtained from Jackson laboratories (Bar Harbor, ME, USA).All mice were housed under the same controlled conditions (12:12 h light–dark cycle) with free access to food and water. All animals were maintained on a C57BL/6 background. Genotyping of TgCre mice was done through Transnetyx service. Male mice were used between 6 and 10 months at the time of study. All of the procedures utilized in this study were approved by the University of Minnesota Animal care and Use Committee.
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MDX and B10 Mice Breeding and Housing
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The C57BL/10ScSn-Dmd (MDX) and C57BL/10J (B10) mice were acquired from the Jackson Laboratory. They were bred and raised from birth at the Pre-Clinical Research Authority, located at the Ruth and Bruce Rappaport Faculty of Medicine, Technion. The mice were kept in mating cages with regular access to food and water. At three weeks of age, they were weaned into individual cages.
9
Muscular Dystrophy Mouse Models
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C57BL/10ScSn-Dmdmdx, C57BL/10ScSn, and C57BL/6J mice were purchased from the Jackson laboratory (Bar Harbor, ME, USA). Both male and female mice were used. The mice were housed in the Histology Department–accredited animal facility at the University of Sapienza. All the procedures were approved by the Italian Ministry for Health and were conducted according to the EU regulations and the Italian Law on Animal Research.
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Duchenne Muscular Dystrophy Mouse Model
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C57BL/10ScSn-Dmd mdx , C57BL/10ScSn, and C57BL/6J mice were purchased from the Jackson laboratory (Bar Harbor, ME, USA). Both male and female mice were used. The mice were housed in the Histology Department-accredited animal facility at the University of Sapienza. All the procedures were approved by the Italian Ministry for Health and were conducted according to the EU regulations and the Italian Law on Animal Research.
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