Sample of Sefsol-218 was kindly gifted by Nikko Chemicals (Tokyo, Japan). Diethylene glycol monoethyl ether (Transcutol-P) was kindly provided by Gattefosse Corp. (France). Polyoxyl-35 castor oil (Cremophor-EL) was obtained as gift sample from BASF Co. (Germany). Streptozotocin (STZ) was purchased from Himedia Laboratories Pvt. Ltd (Mumbai, India). Glimepiride was obtained as a gift sample from USV Pvt. Ltd. (Baddi, India). All other chemicals and reagents used were of analytical grade.
Streptozotocin (stz)
Manufactured by HiMedia
Sourced in India
Streptozotocin is a laboratory chemical used in research applications. It is a white to pale yellow crystalline powder. Streptozotocin is commonly used in the induction of experimental diabetes in animal models.
Automatically generated - may contain errors
Lab products found in correlation
Bovine serum albumin (bsa), by Merck Group (3 mentions)
Rutin, by Merck Group (3 mentions)
Nicotinamide, by HiMedia (3 mentions)
Bradford reagent, by Merck Group (2 mentions)
Intestinal acetone powders from rat, by Merck Group (2 mentions)
Gallic acid, by Merck Group (2 mentions)
Thiobarbituric acid, by HiMedia (2 mentions)
Polyoxyl 35 castor oil cremophor el, by BASF (1 mentions)
Acarbose, by Bayer (1 mentions)
Protocatechuic acid, by Merck Group (1 mentions)
Nitro blue tetrazolium, by Sisco Research Laboratories (1 mentions)
2 4 dinitrophenylhydrazine, by Sisco Research Laboratories (1 mentions)
Phenazinemethosulphate, by Sisco Research Laboratories (1 mentions)
Sodium azide, by Sisco Research Laboratories (1 mentions)
Trichloroacetic acid, by Sisco Research Laboratories (1 mentions)
Thiobarbituric acid, by Sisco Research Laboratories (1 mentions)
Ammonium sulphate, by Sisco Research Laboratories (1 mentions)
1 chloro 2 4 dinitrobenzene, by Sisco Research Laboratories (1 mentions)
Ethylenediaminetetraacetic acid, by Sisco Research Laboratories (1 mentions)
5 5 di thio bi 2 nitrobenzoic acid, by Sisco Research Laboratories (1 mentions)
21 protocols using streptozotocin (stz)
1
Formulation and Evaluation of Sefsol-218 Loaded Nanoparticles
2
Streptozotocin-Induced Diabetic Model
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Streptozotocin (STZ) was purchased from HiMedia Laboratories Pvt. Ltd., Mumbai. Metformin was obtained from Dr. Reddy's laboratories, Hyderabad. Different biochemical analysis kits were purchased from Crest Biosystems, a division of Coral Clinical Systems, India. Glucometer and blood glucose test strips of Contour TS, Bayer Pharmaceuticals Pvt. Ltd., India, and urine analysis reagent strips (glucose-ketone) of Dirui Industrial Co. Ltd., China, were purchased. All other chemicals used for the study were of analytical grade.
3
Streptozotocin-Induced Diabetes Protocol
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Streptozotocin (STZ) was procured from Himedia Laboratories, Mumbai, India. Porcine pancreatic α-amylase was procured from SRL Pvt. Ltd., Mumbai, India. Merckotest glucose oxidase peroxidase (GOD/POD) kit, insulin kit, TC, TG kits were obtained from Merck, India. Acarbose was procured from Bayer Pharmaceuticals and glibenclamide was obtained from Sun Pharmaceuticals. All other chemicals and solvents were of analytical grade.
4
Streptozotocin-Induced Diabetes Protocol
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Streptozotocin was procured from Hi-media (Mumbai, India). Protocatechuic acid (≥97%), Bradford reagent and bovine serum albumin were procured from Sigma-Aldrich (St. Louis, MO, USA). The antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) and Sigma-Aldrich (St. Louis, MO, USA). The kits/reagents for biochemical assays for estimating different biochemical parameters were bought from Span diagnostic, Ltd, India and Sigma-Aldrich, USA. All other reagents, solvents, and chemicals used were of analytical grade.
5
Diabetic Rat Model Preparation
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All chemicals used in these experiments were of analytical grade. PYP IB, Streptozotocin (STZ), and Amylase HR reagent obtained from Himedia Laboratories Pvt. Ltd. (Mumbai, India) and Pro Lab Marketing Pvt. Ltd. (New Delhi, India), respectively. Intestinal acetone powders from rats purchased from Sigma Aldrich (Mumbai, India). Glibenclamide and rat feed procured from Avantis Pharma Ltd. (Mumbai, India) and Hindustan Lever Ltd. (Mumbai, India), respectively.
6
Comprehensive Biochemical Analysis of Streptozotocin-Induced Diabetic Rats
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Streptozotocin was procured from Hi-media (Mumbai, India). Ammonium sulphate, 1-chloro-2,4-dinitrobenzene, ethylenediaminetetraacetic acid, 2,4-dinitro-phenyl-hydrazine, 5,5-di-thio-bi(2-nitrobenzoic acid), potassium dihydrogen phosphate, N-ethylmaleimide, reduced nicotinamide adenine dinucleotide, nitro blue tetrazolium, sodium pyrophosphate, phenazinemethosulphate, thiobarbituric acid, reduced glutathione, sodium azide, trichloro acetic acid and 5-thio-2-nitrobenzoic acid were obtained from Sisco Research Laboratory (India). Bradford reagent, antibodies and bovine serum albumin were procured from Sigma-Aldrich (St. Louis, USA). The kits for different assays for different biochemical parameters were purchased from Span diagnostic Ltd., India. All other reagents and chemicals used were of analytical grade.
7
Evaluation of Antidiabetic Potentials of Ojamin
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The Ojamin (OJ) was obtained as a gift sample from M/s Tate Remedies, Pune, India for the study. Gallic acid (Thomas Beaker Chemicals Pvt. Ltd, India), Rutin (Sigma–Aldrich, India) and streptozotocin (Himedia Lab Pvt. Ltd, India) were purchased from the local market. Glucose estimation kit, total cholesterol estimation kit, HDL-cholesterol estimation kit and triglyceride estimation kit manufactured by Benesphera Diagnostics, India were used for the study. All other chemicals and reagents used were of analytical grade and procured from approved vendors. Instruments such as analytical balance (Schimadzu, AUW 220D), UV–visible spectrophotometer (Varian-Cary 100), cold centrifuge (Bioera, BL-165-D), homogenizer (Biolab, B244), ulrasonicator (Ultrasonics, 5.5L-150H), pH meter (Equip-Tronics, EQ-621), UV-semiautoanalyzer (Benesphera, C61) were used for the study.
8
Evaluation of Anti-Diabetic Drug MT
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MT was purchased from Cipla Pharmaceuticals (Mumbai, India). Streptozotocin from Hi-Media Laboratories Pvt. Ltd., (Mumbai, India). High performance liquid chromatography (HPLC) grade acetonitrile was procured from Rankem, New Delhi. Analytical grade potassium dihydrogen orthophosphate was obtained from Qualigen fine chemicals; Thermo Electron LLS India Pvt Ltd. Water for HPLC was purchased from Nice Chemicals Pvt Ltd., Kochi, Laboratory grade orthophosphoric acid was obtained from SD Fine Chem. Ltd., Mumbai.
9
Biochemical Analysis of Metabolic Markers
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The chemicals used during the experiments are purely analytical grade with high strength such as Sodium Chloride, Triton WR1339, streptozotocin (STZ), nicotinamide (NA) from Himedia Lab, Mumbai, whereas Atorvastatin from Ranbaxy Lab. Besides, the biochemical estimation kits such as glucose, cholesterol, and triglyceride kits were purchased from the Crest biosystem.
10
Diabetic Rat Model Induction
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Sitagliptin and coenzyme Q10 were obtained from Zydus Cadila, Ahmedabad, India. Streptozotocin and nicotinamide were purchased from Himedia (Mumbai, India). Kits used in the study were procured from standard company. All other chemicals and reagents used in the study were of analytical grade.
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