18f florbetapir

Manufactured by Siemens

18F-Florbetapir is a radioactive tracer used in positron emission tomography (PET) imaging. It is designed to bind to beta-amyloid deposits in the brain, which are associated with Alzheimer's disease. The primary function of 18F-Florbetapir is to aid in the detection and assessment of beta-amyloid pathology in the brain.

Automatically generated - may contain errors

Lab products found in correlation

Biograph mct scanner, by GE Healthcare (2 mentions) Discovery 710 pet ct scanner, by GE Healthcare (2 mentions) Discovery pet ct 710, by GE Healthcare (1 mentions) Biograph mct, by GE Healthcare (1 mentions) Biograph mct flow pet ct scanner, by Siemens (1 mentions)

4 protocols using 18f florbetapir

Multimodal PET Imaging Protocols

Check if the same lab product or an alternative is used in the 5 most similar protocols

Fifty-nine ¹⁸F-Florbetapir- (Amyvid) and 31 ¹⁸F-Flutemetamol-PET (Vizamyl) data were obtained using Siemens BiographTM mCT and GE Healthcare Discovery PET/CT 710 scanners of varying resolution and following different platform-specific acquisition protocols. The ¹⁸F-Florbetapir images were acquired 50–70 min after injection and the ¹⁸F-Flutemetanol images 90–120 min after injection. PET images were reconstructed according to the ADNI protocol in order to increase data uniformity across the multicenter acquisitions. More information on the different imaging protocols for PET acquisition can be found on the ADNI website³.

Giannakopoulos P., Montandon M.L., Rodriguez C., Haller S., Garibotto V, & Herrmann F.R. (2021). Prediction of Subtle Cognitive Decline in Normal Aging: Added Value of Quantitative MRI and PET Imaging. Frontiers in Aging Neuroscience, 13, 664224.

+ Open protocol

+ Expand

Multicenter PET Amyloid Imaging Protocol

Cited 1 time

Check if the same lab product or an alternative is used in the 5 most similar protocols

One hundred twenty-two 18F-Florbetapir (Amyvid) and 8 18F-Flutemetanol PET (Vizamyl) data were acquired on two PET scans (Siemens BiographTM mCT scanner and GE Healthcare Discovery PET/CT 710 scanner) of varying resolution and following different platform-specific acquisition protocols. The 18F-Florbetapir images were acquired 50–70 min after injection, and the 18F-Flutemetanol PET images were acquired 90 to 120 min after injection. PET images were reconstructed using the parameters recommended by the ADNI protocol aimed at increasing data uniformity across the multicenter acquisitions (22 (link)).
Amyloid positivity was visually assessed following standardized procedures approved by the European Medicinal Agency. Moreover, all scans were intensity normalized using the thalamus-pons as target region as described by Lilja et al. (34 (link)), and cortical standard uptake value ratios (SUVRs) were then calculated.

Giannakopoulos P., Rodriguez C., Montandon M.L., Garibotto V., Haller S, & Herrmann F.R. (2020). Personality Factors' Impact on the Structural Integrity of Mentalizing Network in Old Age: A Combined PET-MRI Study. Frontiers in Psychiatry, 11, 552037.

+ Open protocol

+ Expand

Amyloid PET Imaging in the Brain

Check if the same lab product or an alternative is used in the 5 most similar protocols

Brain cortical amyloid burden was measured using ¹⁸F-florbetapir (Amyvid^™). Each PET scan was obtained as a 3D acquisition over 10 min (one bed position) on a Siemens Biograph mCT Flow PET/CT scanner approximately 50 min following the injection of 370 MBq (10 mCi) of ¹⁸F-florbetapir. Images were reconstructed using a 400 × 400 matrix (zoom × 2) with iterative (TrueX) and time of flight reconstruction algorithms. A standard low dose CT of the brain was acquired for attenuation correction. No participants reported adverse reactions.

Benitez A., Jensen J.H., Thorn K., Dhiman S., Fountain-Zaragoza S., Rieter W.J., Spampinato M.V., Hamlett E.D., Nietert P.J., de Fatima Falangola M, & Helpern J.A. (2022). Greater diffusion restriction in white matter in Preclinical Alzheimer’s disease. Annals of neurology, 91(6), 864-877.

+ Open protocol

+ Expand

Multimodal PET Imaging of Amyloid

Check if the same lab product or an alternative is used in the 5 most similar protocols

Seventy-seven ¹⁸F-Florbetapir- (Amyvid) and fifty-six ¹⁸F-Flutemetanol-PET (Vizamyl) data were acquired on 2 different instruments (Siemens BiographTM mCT scanner and GE Healthcare Discovery PET/CT 710 scanner) of varying resolution and following different platform-specific acquisition protocols. The ¹⁸F-Florbetapir images were acquired 50–70 min after injection and the ¹⁸F-Flutemetanol images 90–120 min after injection. PET images were reconstructed using the parameters recommended by the ADNI protocol aimed at increasing data uniformity across the multicenter acquisitions. More information on the different imaging protocols for PET acquisition can be found on the ADNI web site¹.

Haller S., Montandon M.L., Rodriguez C., Garibotto V., Lilja J., Herrmann F.R, & Giannakopoulos P. (2019). Amyloid Load, Hippocampal Volume Loss, and Diffusion Tensor Imaging Changes in Early Phases of Brain Aging. Frontiers in Neuroscience, 13, 1228.

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!