B6.129x1 mpotm1lus j mpo

Manufactured by Jackson ImmunoResearch

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B6.129X1-Mpotm1Lus/J (Mpo−/−) is a genetically modified mouse strain with a targeted mutation in the Mpo gene, leading to a deficiency in myeloperoxidase. This mouse model is used in research applications to study the role of myeloperoxidase in various biological processes.

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Lab products found in correlation

C57bl 6j, by Jackson ImmunoResearch (2 mentions) B6.129s cybbtm1din j, by Jackson ImmunoResearch (1 mentions) Inos b6.129p2 nos2tm1lau j, by Jackson ImmunoResearch (1 mentions) C57bl 6, by Jackson ImmunoResearch (1 mentions)

3 protocols using b6.129x1 mpotm1lus j mpo

Microbiome Equilibration for EAE Induction

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C57BL/6J, B6.129X1-Mpo^tm1Lus/J (Mpo^−/−) and B10.PL-H2^u H2-T18^a/(73NS)SnJ (B10.PL) mice were purchased from The Jackson Laboratory (Bar Harbor, ME). MBP-TCR transgenic mice were described previously (Dittel et al. 1999 (link)). Upon receipt C57BL/6 and Mpo^−/− mice were cohoused with mice from the Dittel colony for at least two weeks prior to EAE induction to equilibrate the microbiome of the two groups of mice. Mice were housed under SPF conditions in the Translational Biomedical Research Center of the Medical College of Wisconsin and all animal procedures were approved by the Institutional Animal Care and Use Committee.

Zhang H., Ray A., Miller N.M., Hartwig D., Pritchard KA J.r, & Dittel B.N. (2015). Inhibition of Myeloperoxidase at the Peak of Experimental Autoimmune Encephalomyelitis Restores Blood-Brain-Barrier Integrity and Ameliorates Disease Severity. Journal of neurochemistry, 136(4), 826-836.

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Genetic mouse models for in vivo research

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Breeding pairs of C57BL/6J, B6.129S-Cybb^tm1Din/J (gp91^phox-/-), B6.129X1-Mpo^tm1Lus/J (MPO^-/-) and B6.129P2-Nos2^tm1Lau/J (iNOS^-/-) mice were purchased from Jackson Laboratory (Bar Harbor, USA). We used 8- to 12-week-old female mice for our in vivo experiments, and these animals were all bred and raised under the same conditions in the central animal housing facility of the University of Tübingen. B6(Cg)-Padi4^tm1.2Kmow/J mice (PAD4^-/-) were kindly provided by Prof. Wolfram Ruf, University of Mainz. All the experimental protocols were approved by Regierungspräsidium Tübingen.

Mehling R., Schwenck J., Lemberg C., Trautwein C., Zizmare L., Kramer D., Müller A., Fehrenbacher B., Gonzalez-Menendez I., Quintanilla-Martinez L., Schröder K., Brandes R.P., Schaller M., Ruf W., Eichner M., Ghoreschi K., Röcken M., Pichler B.J, & Kneilling M. (2021). Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions. Theranostics, 11(2), 470-490.

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Murine Knockout Pathogen-Free Model

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C57BL/6 and B6.129X1-Mpotm1Lus/J (Mpo^−/−) mice were purchased from The Jackson Laboratory (Bar Harbor, ME) and housed under specific pathogen-free conditions in the Translational Biomedical Research Center, Medical College of Wisconsin. All experiments were conducted with Institutional Animal Care and Use Committee approval.

Strzepa A., Gurski C.J., Dittel L.J., Szczepanik M., Pritchard KA J.r, & Dittel B.N. (2021). Neutrophil-Derived Myeloperoxidase Facilitates Both the Induction and Elicitation Phases of Contact Hypersensitivity. Frontiers in Immunology, 11, 608871.

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