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Avadomide

Manufactured by MedChemExpress
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Sourced in United States

Avadomide is a laboratory reagent produced by MedChemExpress. It functions as a cereblon modulator, which is a protein involved in the regulation of various cellular processes. The core function of Avadomide is to serve as a tool for research and scientific investigation, without making claims about its intended use or potential applications.

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Lab products found in correlation

Ionomycin, by Cayman Chemical (1 mentions) Iberdomide, by MedChemExpress (1 mentions) Bay11 7082, by Fujifilm (1 mentions) Phorbol 12 myristate 13 acetate, by Adipogen (1 mentions) Navtemadlin, by MedChemExpress (1 mentions) Z vrpr fmk, by Adipogen (1 mentions) Lenalidomide, by Cayman Chemical (1 mentions) Mg132, by MedChemExpress (1 mentions) Siremadlin, by MedChemExpress (1 mentions) Idasanutlin, by MedChemExpress (1 mentions) Gemcitabine, by Eli Lilly (1 mentions)

2 protocols using avadomide

1

Synthesis and Procurement of Pharmacological Agents

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FPFT-2216 and pomalidomide were synthesized by Fujimoto Pharmaceutical Group. Avadomide, iberdomide, siremadlin, idasanutlin, navtemadlin, milademetan, and MG-132 were procured from MedChemExpress; Z-VRPR-FMK and phorbol 12-myristate 13-acetate (PMA) were procured from Adipogen Life Sciences. Lenalidomide and ionomycin were obtained from Cayman Chemical, BAY 11-7082 from FUJIFILM Wako Pure Chemical Corporation, and safimaltib from Selleck Chemicals. Rituxan Intravenous Infusion (rituximab) was obtained from Zenyaku Kogyo. Z-VRPR-FMK was dissolved in PBS, and other reagents were dissolved in DMSO. The final DMSO concentration used for in vitro experiments did not exceed 0.25%.
Kanaoka D., Yamada M., Yokoyama H., Nishino S., Kunimura N., Satoyoshi H., Wakabayashi S., Urabe K., Ishii T, & Nakanishi M. (2024). FPFT-2216, a Novel Anti-lymphoma Compound, Induces Simultaneous Degradation of IKZF1/3 and CK1α to Activate p53 and Inhibit NFκB Signaling. Cancer Research Communications, 4(2), 312-327.
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2

Preparation of Avadomide and Gemcitabine

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Avadomide (Med Chem Express, NJ, USA) was dissolved in dimethyl sulfoxide (DMSO; 100 mM), and gemcitabine (GEM; Eli Lilly Pharmaceuticals, IN, USA) was dissolved in diluted water (1 mg/mL) and stored at − 80 °C until further use.
Nishi H., Gotoh K., Tomimaru Y., Kobayashi S., Sasaki K., Iwagami Y., Yamada D., Akita H., Asaoka T., Noda T., Takahashi H., Tanemura M., Doki Y, & Eguchi H. (2023). Anti-tumor effect of avadomide in gemcitabine-resistant pancreatic ductal adenocarcinoma. Cancer Chemotherapy and Pharmacology, 92(4), 303-314.
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