All enrolled patients underwent a computed tomography simulation scan encompassing the entire head region, with 2-mm slice thickness, using a thermoplastic mask for immobilization. All patients should have had brain MRI before HA-WBRT so as to delineate the bilateral hippocampus; the delineation was established and confirmed by an experienced radiation oncologist. HA regions will be generated by 3-dimensionally expanding the hippocampal contours by 5 mm to allow for the sharp dose fall-off between the bilateral hippocampal structures. The clinical tumor volume (CTV) is defined as the whole-brain parenchyma. The PTV is defined as the CTV minus the HA regions. Treatment plans were generated for 6-MV photons beams using the Pinnacle (Philips, Fitchburg, WI) and TomoTherapy (Accuray, Sunnyvale, CA) planning systems. The detailed planning technique was reported in our previous study (14). The prescribed dose of prophylactic cranial irradiation (PCI) was 25 to 27 Gy in 10 to 15 fractions in patients with small cell lung cancer (SCLC), or 30 Gy in 10 to 12 fractions for brain metastases. An additional boost to gross lesions was allowed. Follow-up brain MRI was arranged at 3-month intervals after HA-WBRT or shorter interval upon recurrent symptoms of brain metastasis including headaches, seizures, or detectable changes in mental or motor function.
Tomotherapy
Manufactured by Accuray
Sourced in United States
TomoTherapy is a radiation therapy system designed for the treatment of cancer. It utilizes a linear accelerator that rotates around the patient, delivering precise and targeted radiation. The system combines imaging and treatment planning capabilities to enable accurate and efficient delivery of radiation therapy.
Automatically generated - may contain errors
Lab products found in correlation
Versa hd, by Elekta (2 mentions)
Clinac ix, by Agilent Technologies (2 mentions)
Pinnacle3 treatment planning system, by Philips (1 mentions)
Bluebag, by Elekta (1 mentions)
Syngo pt planning version 13, by Siemens (1 mentions)
Tomotherapy planning station, by Accuray (1 mentions)
Artiste, by Siemens (1 mentions)
Truebeam, by Agilent Technologies (1 mentions)
Lightspeed, by GE Healthcare (1 mentions)
Raystation, by RaySearch Laboratories (1 mentions)
Multiplan cyberknife, by Accuray (1 mentions)
Eclipse planning system, by Agilent Technologies (1 mentions)
Pinnacle3, by Philips (1 mentions)
Lightspeed rt16, by GE Healthcare (1 mentions)
Agility mlc, by Elekta (1 mentions)
22 protocols using tomotherapy
1
Hippocampal-Avoidance Whole-Brain Radiotherapy
2
Multimodal Radiation Therapy for Solid Tumors
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
No patient who had an irradiation before, and all underwent a preceding tumor resection. All patients received a mixed beam regimen as described. The additive RT was performed as a combined concept consisting of a combination of photon radiation (3D-planned, image-guided IMRT (TomoTherapy® (Accuray, Sunnyvale, CA, USA)), one fraction per day, 5 fractions per week) and a separate carbon ion boost (3D-planned, image-guided particle therapy, carbon ions, active rasterscanning, alpha/beta = 2, one fraction per day, 6 fractions per week). The total dose was 48–56 Gy photons (single dose 2 Gy) and 18–24 Gy (RBE) carbon ions (single dose 3 Gy (RBE)). The cumulative dose was 68–74 Gy (EQD2). The total dose of 74 GyE corresponds to a biological effective dose of 80 Gy BED. In 60 of 67 patients the cervical lymphatic drainage was included in the clinical target volume (ipsilateral 39 patients (65%), bilateral 21 patients (35%) with a median cumulative total dose of 50 Gy (range 48–66). The main treatment characteristics are listed in Table 4 . The median CTV of photon radiation was 346 ccm (range: 21–921 ccm). The median CTV of the carbon ion boost radiation consisted of 134 ccm (range: 21–411 ccm).
3
Intensity-Modulated Radiation Therapy for Head and Neck Cancer
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Computed tomography-based, intensity-modulated RT with 6-MV photons (Tomotherapy,
Accuray, Inc, Madison, Wisconsin; Versa HD, Elekta, Crawley, West Sussex, United
Kingdom) was employed at our institution. Radiation therapy with or without
concurrent chemoradiation therapy (CCRT) was initiated 4 to 6 weeks after
surgery using 6-MV photon beams and IMRT with the SIB or sequential technique
comprising 1.8- or 2-Gy fractions on 5 consecutive days a week for 7 weeks. The
choices of dose and treatment techniques were made at the discretion of the
primary oncologist. There were 3 radiation oncologists (Drs A, B, and C) in our
department who belonged to the head and neck cancer subspecialty. The
percentages of patients treated by Dr A versus Dr B versus Dr C in the SIB and
sequential groups were 34.9% versus 6% versus 58.7% and 62.2% versus 8.4% versus
29.4%, respectively. Target regions and normal structures were contoured using
the Pinnacle 3 Treatment Planning System (Philips Healthcare, Madison,
Wisconsin). The preoperative magnetic resonance images were retrieved on a
Pinnacle workstation and fused with the CT images by rigid image registration to
contour the postoperative flap and confirm the location of the preoperative
gross tumor to avoid miscontouring the gross tumor due to structural changes
caused by surgery.
Accuray, Inc, Madison, Wisconsin; Versa HD, Elekta, Crawley, West Sussex, United
Kingdom) was employed at our institution. Radiation therapy with or without
concurrent chemoradiation therapy (CCRT) was initiated 4 to 6 weeks after
surgery using 6-MV photon beams and IMRT with the SIB or sequential technique
comprising 1.8- or 2-Gy fractions on 5 consecutive days a week for 7 weeks. The
choices of dose and treatment techniques were made at the discretion of the
primary oncologist. There were 3 radiation oncologists (Drs A, B, and C) in our
department who belonged to the head and neck cancer subspecialty. The
percentages of patients treated by Dr A versus Dr B versus Dr C in the SIB and
sequential groups were 34.9% versus 6% versus 58.7% and 62.2% versus 8.4% versus
29.4%, respectively. Target regions and normal structures were contoured using
the Pinnacle 3 Treatment Planning System (Philips Healthcare, Madison,
Wisconsin). The preoperative magnetic resonance images were retrieved on a
Pinnacle workstation and fused with the CT images by rigid image registration to
contour the postoperative flap and confirm the location of the preoperative
gross tumor to avoid miscontouring the gross tumor due to structural changes
caused by surgery.
4
SBRT for Primary Renal Cell Carcinoma
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Patients were positioned with a TomoTherapy™ (Accuray, Madison, WI, USA) device, which delivered arc x-ray therapy of 6 MV. Prior to CT, patients were immobilized with the BlueBAG™ (Elekta, Stockholm, Sweden) BodyFIX Vacuum Cushions system and the abdominal compression plate (ACP) to minimize breathing motion. The gross tumor volume (GTV) was contoured on different reconstructions of the simulation CT with breath-phased 3D CT scan to encompass the motion and to create an internal target volume (ITV). For the last patients included, the GTV was contoured on the different respiratory phases of a 4D simulation scan. A 5 mm expansion was given to derive the planning target volume (PTV). The dosimetry was evaluated on Accuray’s VOLO™ (Accuray, Madison, WI, USA) software. The objective prescription isodose was 90%. Sessions were spaced 48 h apart and were delivered on non-consecutive days (one day interval). SBRT procedures were adapted from consensus statements from the International Radiosurgery Oncology Consortium for primary renal cell carcinoma [10 (link),11 (link)]. The total dose administered was in accordance with De Meerleer’s guidelines [12 (link)].
5
Combined IMRT and CIRT for Patient Treatment
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Treatment planning was performed using native and contrast enhanced CT/MRI. Patients were immobilized with individualized thermoplastic head masks. Technical details of CIRT are described elsewhere (24 (link), 25 (link)). Treatment planning for CIRT was performed using Syngo PT Planning, Version 13 (Siemens, Erlangen, Germany) and TomoTherapy®-Planning Station (Accuray, Sunnyvale, CA, USA) for photon radiotherapy planning. Patients were treated with a fixed horizontal beam/gantry for CIRT utilizing 1-2 coplanar/non-coplanar beams.
All patients received combined IMRT and CIRT. The base plan was performed using a helical intensity-modulated radiotherapy (IMRT) with daily image guidance (TomoTherapy®, Accuray, Sunnyvale, CA, USA), with 5 daily fractions per week (Figure 1 ).
All patients received combined IMRT and CIRT. The base plan was performed using a helical intensity-modulated radiotherapy (IMRT) with daily image guidance (TomoTherapy®, Accuray, Sunnyvale, CA, USA), with 5 daily fractions per week (
6
Cochlea Contouring and Radiotherapy Dosing
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
In all patients RT was administered using contrast-enhanced computed tomography (CT) or positron emission tomography-CT. Axial CT images were taken from the top of the head to the lower neck with patients in treatment position. In all cases slice thickness was 3 mm and the cochlea was contoured on the bone window of the CT. Figure 1 shows the contouring of the cochlea on CT (on the bone window) and T2-weighted magnetic resonance imaging.
RT was administered using a linear accelerator device (Varian Clinac DHX, Varian Medical Systems, Inc., Palo Alto, CA, USA) or TomoTherapy (Accuray, USA). The 3D-conformal radiation therapy (3D-CRT) planning was done using the Varian Eclipse treatment planning (Varian Medical Systems, Inc., Palo Alto, CA, USA), taking into account tissue inhomogeneity during dose calculation. IMRT planning was done using the TomoTherapy Planning Workstation (TomoTherapy Inc., Madison, WI, USA). RT was given with 6 MV photons on both devices. RT was prescribed to a total dose of 46–70 Gy at 1.8–2 Gy per fraction with 5 fractions per week.
RT was administered using a linear accelerator device (Varian Clinac DHX, Varian Medical Systems, Inc., Palo Alto, CA, USA) or TomoTherapy (Accuray, USA). The 3D-conformal radiation therapy (3D-CRT) planning was done using the Varian Eclipse treatment planning (Varian Medical Systems, Inc., Palo Alto, CA, USA), taking into account tissue inhomogeneity during dose calculation. IMRT planning was done using the TomoTherapy Planning Workstation (TomoTherapy Inc., Madison, WI, USA). RT was given with 6 MV photons on both devices. RT was prescribed to a total dose of 46–70 Gy at 1.8–2 Gy per fraction with 5 fractions per week.
7
Neoadjuvant IMRT and Capecitabine for Cancer
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Intensity-modulated radiotherapy was administered conventionally once daily 5 times/week using TomoTherapy® (Hi-Art® treatment system; Accuray). Neoadjuvant radiotherapy (NART) consisted of 50 Gy delivered to the posterior pelvis in 25 fractions of 2 Gy each. Concurrent neoadjuvant chemotherapy was delivered in 5-day courses during the first to fifth weeks of NART. Capecitabine was administered orally at a dose of 1,700 mg/m2/day.
8
Helical Tomotherapy for Brain Metastases
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
All patients were treated at Fukui Saiseikai Hospital using helical Tomotherapy (HT, Tomotherapy®, Accuray, Madison, WI, USA). Between August 2009 and June 2013, a total of 54 patients with 128 brain metastases matched the inclusion criteria.
9
Comparative Evaluation of On-Board Imaging Systems
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Four on‐board imaging systems were evaluated and compared to conventional CT: kV CBCT on the TrueBeam (Varian, Palo Alto, CA), kV CBCT on the VersaHD (Elekta, Crawley, UK), MV CBCT on the Artiste (Siemens, Munich, Germany), and MV CT on the TomoTherapy (Accuray, Sunnyvale, CA). Each imaging system had its own artifacts, and vendors provided different choices of filters for reconstruction, usually based on the treatment site and size. These imaging protocols were used as suggested by the vendors and no additional in‐house filters or image corrections were applied.
10
Postoperative Radiotherapy for Lip Cancer
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
All patients underwent surgical resection of the lip cancer with removal of all
involved parts. In all patients, RT was carried out postoperatively using photon
irradiation with either 3D-planned, image-guided intensity-modulated
radiotherapy (IMRT) (TomoTherapy®; Accuray, Sunnyvale, CA) or volumetric
modulated arc therapy (Elekta, Sweden), with treatment delivered one fraction
per day and five fractions per week. Selection of the RT modality and dose
fractionation was dependent on tumor characteristics, such as tumor thickness
and lymph node involvement (Figure 1 ). Lip cancer is often stigmatizing; Figure 1 illustrates good cosmetic
results 6 and 12 months after postoperative RT.
Aftercare for lip cancer consists of clinical examination. In our institution,
follow-up consisted of computed tomographic (CT) imaging every 3 months within
the first year after completion of RT, as well as regular clinical examination
to evaluate outcome and potential tumor progression in the maxillofacial surgery
department. After the first year, the frequency of CT imaging and clinical
examinations was at 6-month intervals, and annually thereafter. Toxicity was
classified according to the Common Terminology Criteria for Adverse Events v4.03
(CTCAE).
involved parts. In all patients, RT was carried out postoperatively using photon
irradiation with either 3D-planned, image-guided intensity-modulated
radiotherapy (IMRT) (TomoTherapy®; Accuray, Sunnyvale, CA) or volumetric
modulated arc therapy (Elekta, Sweden), with treatment delivered one fraction
per day and five fractions per week. Selection of the RT modality and dose
fractionation was dependent on tumor characteristics, such as tumor thickness
and lymph node involvement (
results 6 and 12 months after postoperative RT.
Aftercare for lip cancer consists of clinical examination. In our institution,
follow-up consisted of computed tomographic (CT) imaging every 3 months within
the first year after completion of RT, as well as regular clinical examination
to evaluate outcome and potential tumor progression in the maxillofacial surgery
department. After the first year, the frequency of CT imaging and clinical
examinations was at 6-month intervals, and annually thereafter. Toxicity was
classified according to the Common Terminology Criteria for Adverse Events v4.03
(CTCAE).
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!