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Isite

Manufactured by Philips
Sourced in United States

The Philips ISite is a laboratory equipment device designed for image acquisition and analysis. It provides core functionality for capturing and processing images, without further interpretation or extrapolation on its intended use.

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12 protocols using isite

1

Analyzing Secondary ACL Deficiency

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Secondary signs of ACL deficiency were analyzed separately by two readers (EMW and SN). Blinding proved infeasible because the joints’ configuration was readily discernible. Mid-sagittal slices of the medial and lateral femorotibial compartments were identified and used to quantify knee joint motion as before [16 (link)]: (i) lateral meniscus displacement distance (LMD); (ii) medial meniscus displacement distance (MMD); (iii) lateral tibial plateau displacement distance relative to the lateral femoral condyle (LTP/LFC); and (iv) medial tibial plateau displacement distance relative to the medial femoral condyle (MTP/MFC) (Figure 4). Manual reference measurements were performed using the in-house PACS (iSite, Philips) and its image analysis toolbox. The inter-reader agreement was determined using the intraclass-correlation-coefficient (online calculator v1.5, Mangold International).
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2

Quantitative and Qualitative Bladder Tumor Assessment

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The 1.7-s temporal resolution data sets were evaluated using in-house software (FireVoxel;https://files.nyu.edu/hr18/public/projects.html) by a fellowship trained radiologist with two years of experience (JR), blinded to the pathologic findings. First, a small circular region-of-interest (ROI) was placed within the common femoral artery in order to obtain a kinetic curve of signal intensity (SI) vs. time within the artery across all time points to serve as an arterial input function (AIF). Then, a free-hand 3D ROI was traced around the bladder tumor on multiple slices using a single time-point (mean tumor ROI size 7.6 ± 21.1 mm3), and a free-hand 3D ROI of comparable size was also traced on benign bladder wall. A two-compartment general kinetic model (GKM) was applied using the defined AIF to compute Ktrans for tumor and benign bladder for each patient [16 (link)].
At least three months following the quantitative assessment, the above radiologist, as well as an additional board-certified radiologist with seven years of experience (AR), independently reviewed the clinical 25-s temporal resolution data sets for each patient using our institutional PACS (Phillips iSite, Foster City, CA). These readers subjectively scored the visual conspicuity of the bladder lesion on the dynamic GRASP images on a 1–5 scale (5 representing greatest conspicuity).
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3

Radiographic Assessment of Spinal Surgery

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Simple radiographs (anteroposterior [AP] neutral, lateral in flexion, lateral in neutral and lateral in extension) were performed before surgery and at different postoperative periods to control the status of the construction: 6 weeks, 3 months, 6 months, and 12 months. Magnetic resonance imaging (MRI) exams of the lumbar spine were performed at baseline and at 3 months postoperatively for measurement of different radiographic parameters: (1) anterior and posterior disc height, (2) right and left foramen heights, (3) anteroposterior diameter of the spinal canal, and (4) area of the spinal canal. Radiological assessments were done using the digital visualization system iSite-Philips. Two evaluators independently evaluated the radiological parameters. The discrepancies were resolved by consensus.
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4

Chest CT Imaging Standardization Protocol

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Chest CT was performed in the supine position during inspiratory breath-hold from the apex to the lung bases, on either a 64-slice CT scanner (Philips Brilliance, Philips Healthcare, The Netherlands) or on a 128-slice scanner (Toshiba Aquillion, Japan) with or without intravenous contrast media administration at the physician's discretion. Scanning parameters followed institutional protocols for each machine and patient body type and were collimated at 64×0.625 or 0.6 mm, 120 kVp, 667 max mA or 404 max mA, pitch 1.0 or 1.2, and matrix size 512×512. CT images were reconstructed in the transverse plane with 1.0-mm slice thickness and 1.0-mm increment. All images were stored and accessed through an integrated PACS (Picture Archiving and Communication System, PHILIPS iSite, version 4.1.110.0, USA).
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5

Radiographic Evaluation of Bone Implants

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To assess bone quality and implant positioning, radiographs were taken under tiletamine-zolazepam anesthesia (15 mg/kg body weight) at weekly intervals, starting immediately after surgery. Anteroposterior and lateral images were acquired at 85 kV and 20 mAs (Polymobil; Siemens, Germany) on Kodak PQ-phosphor screens (Carestream Health, Rochester, NY). The radiographs were digitized using a CR-975 phosphor screen reader (Carestream Health) and visualized with the Philips iSite software package version 3.5. Radiographs were assessed for signs of osteomyelitis (periosteal elevation, cortical thickening, and osteolysis) (Calhoun and Mader 1997 (link), Odekerken et al. 2013 (link)).
After 6 weeks of follow-up, the animals were killed and the hind leg was excised in a sterile fashion. Ex vivo micro-CT imaging of these excised hind legs was performed directly after death. Images were acquired on an X-rad 225 (Precision X-ray, North Branford, CT), with a field of view 10 cm in diameter, a source-to-axis distance of 30 cm, and a source-to-detector distance of 62 cm. Images were acquired at 80 kVp, with an isotropic spacing of 102 µm and 2.14 mm AI added filtration. The GE MicroView software package version 2.1.2 (GE Healthcare) was used for the image evaluation.
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6

Comprehensive Liver MRI Protocol

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Imaging was performed on 1.5-T and 3.0-T scanners (Siemens, Erlangen, Germany). Liver MRI protocol included axial T1-weighted dual echo in-phase and out-of-phase imaging and axial T2 balanced gradient echo (TrueFISP). Dynamic contrast-enhanced gradient-echo T1-weighted images with fat suppression were obtained at 4 timepoints: pre-contrast, arterial phase (8 s after contrast administration), venous phase (70 s after contrast administration), and delayed phase (180 s contrast administration). The intravenous contrast agents used during the study period were Gadavist (Bayer, Berlin, Germany) and Eovist (Bayer). The contrast injection was performed with 10 cc of the contrast agent injected at a rate of 2 cc/sec, followed by a 10 cc saline flush.
DW imaging consisted of fat-suppressed single-shot echo planar sequences obtained during breath holds and performed at b-values of 50, 400, and 800 s/mm2. ADC maps were automatically calculated and displayed on a standard picture archiving and communication system (iSite, Philips, Amsterdam, The Netherlands).
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7

Magnetic Resonance Imaging Protocols for Inflammatory Bowel Disease

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MRFT and MRE were performed using the same protocol, except for the administration of the contrast agent. In MRFT, the contrast agent was ingested orally and in MRE, injected through a NJT. The NJT was placed under fluoroscopic guidance. MRE was used as the reference standard for evaluation of IBD extension and severity. The patients were instructed to drink 1.350 mL of a barium sulphate suspension (VoLumen®; Bracco Diagnostics, Milan, Italy) within 45–60 min in MRFT and the same amount was given through NJT in MRE.
Scopolaminbutylbromide 20 mg was used twice in both protocols and was administered right before the imaging procedure started and again when 0.1 mmol/kg of gadoterate (gadoterate meglumine; Dotarem®, Guerbet, Roissy, France) was given; maximum was 20 mL. The average duration of the MRI exam was approximately 30 min. All images were transferred to our Picture Archiving and Communication System (iSite, Philips Healthcare).
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8

Oncologic CT Scan Assessment Protocol

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Two fellowship-trained abdominal radiologists (who had 1 year of postfellowship experience exclusively interpreting oncologic scans) independently examined two sets of CT scans performed before and after initiation of pazopanib therapy, which were displayed on a PACS (iSite, Philips Healthcare). Radiologists were blinded to patient outcomes and clinical data.
Representative tumors were selected on axial images according to RECIST 1.1 (i.e., up to two lesions per organ and five lesions per patient) [1 (link)]. Osseous lesions with a soft-tissue component larger than 1 cm were included, whereas sclerotic lesions were excluded. Parenchymal lung lesions were not measured because of limitations regarding assessment of central necrosis caused by cavitation and partial volume effects [12 (link)]. For each lesion, the longest diameter was measured, and ROIs were manually drawn along the lesion margin for measurement of mean attenuation values (Figs. 1A and 1B). Visual assessment was done to determine the presence or absence of central necrosis (used for MASS criteria).
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9

Detecting Prostate Cancer Recurrence via DCE-MRI

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Two fellowship-trained radiologists (AD and JR) with 3 years of experience in prostate MRI independently reviewed the examinations in a random order using a standard clinical PACS (iSite; Philips Healthcare). The radiologists were aware that the patients had an elevated PSA following RP, but were blinded to other clinical details including the specific PSA value. The radiologists viewed only the DCE acquisitions; T2WI and DWI were not assessed in order to ensure that all findings reported by the readers were based on the given DCE sequences under evaluation. The visual assessment was performed by scrolling through serial dynamic time points using the PACS. Pharmacokinetic mapping was not performed.
The radiologists assessed each examination on a 1–5 scale (5 = highest quality) in terms of anatomic clarity and image sharpness. In addition, the radiologists recorded in a binary fashion whether a local recurrence was visualized. The confidence in this determination was recorded for all cases on a 1–5 scale (5 = highest confidence). For those examinations in which a recurrence was visualized, the finding’s conspicuity was recorded on a 1–5 scale (5 = highest conspicuity).
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10

Incidental Gastric Lipoma Diagnosis

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This study was approved by the university institutional review board and, given its
retrospective nature, the requirement for informed consent was waived.
Seven cases of gastric lipoma diagnosed incidentally on CT from 2003 to 2017 were reviewed
by a body trained radiologist on a picture archiving and communication system (PACS; iSite,
Phillips). Recorded variables on CT imaging included mean diameter (average of the
anteroposterior, transverse, and craniocaudal dimension), location within the stomach
(cardia, fundus, body, antrum, pylorus), and mean attenuation in Hounsfield units (HU).
Volume was estimated using the standard ellipsoid formula, V = (π/6)(length ×
width × height). The mean attenuation of lesions was measured by placing the largest
possible round region of interest while attempting to avoid the wall. One patient underwent
MRI, for which T2 and opposed phase gradient echo imaging characteristics of the lesion were
recorded. One patient underwent fludeoxyglucose- positron emission tomography/CT (PET/CT)
imaging. These images were fused and viewed with Aquarius iNtuition (Terarecon Inc.), and a
mean standardized uptake value (SUV) was obtained. Endoscopic images for this case were also
reviewed with a board certified gastroenterologist. Pathology for this case was reviewed
with a board certified pathologist.
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