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Psen1tm1mpm

Manufactured by Jackson ImmunoResearch
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Psen1tm1Mpm is a laboratory product designed for research purposes. It functions as a genetically modified mouse model, with a targeted mutation in the Presenilin 1 (Psen1) gene. The core purpose of this product is to serve as a research tool for studying the role of Presenilin 1 in various biological processes.

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Lab products found in correlation

Taup301, by Jackson ImmunoResearch (2 mentions) Appswe, by Jackson ImmunoResearch (1 mentions)

2 protocols using psen1tm1mpm

1

Establishing 3xTg-AD Mouse Model

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3xTg-AD breeders containing the human APPSwe, tauP301, and Psen1tm1Mpm mutations were obtained from Jackson Labs through the Mutant Mouse Resource and Research Centers (MMRC). Homozygous breeder pairs were used, and pups were weaned on postnatal day 25 (P25). Animals were group-housed (up to 5/cage) with same-sex littermates in standard cages in a temperature and humidity-controlled vivarium on a 12 h/12 h light/dark cycle and had access to food and water as needed. All animal protocols were approved by the Institutional Animal Care and Use Committee (IACUC) at the University of North Carolina at Chapel Hill and were in accordance with NIH regulations (Protocols 20-232.0 and 21-052.0).
Barnett A., David E., Rohlman A., Nikolova V.D., Moy S.S., Vetreno R.P, & Coleman LG J.r. (2022). Adolescent Binge Alcohol Enhances Early Alzheimer’s Disease Pathology in Adulthood Through Proinflammatory Neuroimmune Activation. Frontiers in Pharmacology, 13, 884170.
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2

Transgenic Mouse Model of Alzheimer's

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3xTg-AD breeders (APPSwe, tauP301, and Psen1tm1Mpm, Jackson Lab) were obtained through the Mutant Mouse Resource & Research Centers (MMRC). A homozygous breeder pair strategy was employed, with pups weaned by P30. All animal experiments were approved by the University of North Carolina at Chapel Hill Institutional Animal Care and Use Committee (IACUC) and were in accordance with NIH regulations (Protocols 20-232.0 and 21-052.0).
Tucker A.E., Alicea Pauneto C.D., Barnett A.M, & Coleman LG J.r. (2022). Chronic Ethanol Causes Persistent Increases in Alzheimer’s Tau Pathology in Female 3xTg-AD Mice: A Potential Role for Lysosomal Impairment. Frontiers in Behavioral Neuroscience, 16, 886634.
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