The largest database of trusted experimental protocols

3 protocols using ondansetron hydrochloride dihydrate

1

Comprehensive Pharmacology Reagents Protocol

Check if the same lab product or an alternative is used in the 5 most similar protocols
We purchased common salts and 1-(3-Chlorophenyl) biguanide hydrochloride (mCPBG); gabazine; 1,2-bis(2-aminophenoxy) ethane-N,N,N,N-tetraacetic acid (BAPTA); SCH50911; 6,7-dinitroquinoxaline-2,3-dione (DNQX); tetrodotoxin (TTX); strychnine; SB200646 hydrochloride (SB200646); ritanserin (RIT); ondansetron hydrochloride dihydrate (OND); and 5-HT hydrochloride (5-HT) from Sigma-Aldrich Chemical Company (St Louis, MO, USA). Citalopram hydrobromide, WAY100635, and 1-(3-Chlorophenyl) piperazine hydrochloride (mCPP) from Tocris Bioscience (Ellisville, MO, USA).
+ Open protocol
+ Expand
2

Pharmacological Modulation of Neurotransmitter Signaling

Check if the same lab product or an alternative is used in the 5 most similar protocols
We purchased 1-(3-Chlorophenyl) biguanide hydrochloride (mCPBG), gabazine, DL-2-amino-5-phosphono-valeric acid (DL-APV), 1,2-bis(2-aminophenoxy)ethane-N,N,N,N-tetraacetic acid (BAPTA), SCH50911, 6, 7-dinitroquinoxaline-2, 3-dione (DNQX), tetrodotoxin (TTX), strychnine, SB-200646 hydrochloride (SB200646), ritanserin (RIT), ondansetron hydrochloride dihydrate (OND) and serotonin hydrochloride (5-HT), 2-Aminoethyl diphenylborinate (2-APB) and other common salts from Sigma-Aldrich Chemical Company (St Louis, MO, USA); and Citalopram hydrobromide, WAY100635 and 1-(3-Chlorophenyl) piperazine hydrochloride (mCPP) from Tocris Bioscience (Ellisville, MO, USA).
+ Open protocol
+ Expand
3

Attenuating Acute Hypersensitivity in Neonatal Rats

Check if the same lab product or an alternative is used in the 5 most similar protocols
For 5-HT3R antagonism, the selective 5-HT3R antagonist Ondansetron (OND; ondansetron hydrochloride dihydrate, Sigma-Aldrich, O3639) was dissolved in sterile saline in a concentration of 2 μg/μl. For 5-HT1aR agonism, the selective agonist Buspirone (BUS, buspirone hydrochloride; Sigma-Aldrich, B7148) was dissolved in sterile saline to a concentration of 10 μg/μl. Pilot studies testing 1, 3 and 5 mg/kg BUS and 0.3, 1 and 3 mg/kg OND showed that 3 mg/kg BUS and 3 mg/kg OND were most promising in preventing acute hypersensitivity associated with neonatal repetitive needle pricking (see Figure 1), without adverse side effects (including body weight changes or mortality). Based on pup's body weight per postnatal day, 50 μl solution containing OND (3 mg/kg) or BUS (3 mg/kg) was injected sc. twice daily (at 9 a.m. before the 1st needle prick and 11 a.m. before the 3 rd needle prick). TC and NP animals received an equivalent volume of saline.
+ Open protocol
+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required

Sign up now

Revolutionizing how scientists
search and build protocols!