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3h vincristine

Manufactured by American Radiolabeled Chemicals
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[3H]-Vincristine is a radiolabeled compound that contains the chemotherapeutic agent vincristine, with the addition of a tritium (3H) label. The core function of this product is to serve as a research tool for studies involving the distribution, metabolism, and pharmacokinetics of vincristine.

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Lab products found in correlation

3h cq, by American Radiolabeled Chemicals (1 mentions) 3h quinine, by American Radiolabeled Chemicals (1 mentions) 3h quinidine, by American Radiolabeled Chemicals (1 mentions)

2 protocols using 3h vincristine

1

Radiolabeled Vincristine Uptake in MDR1-Expressing Cells

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[3H]‐Vincristine was purchased from American Radiolabeled Chemicals (St. Louis, MO). GW918 was a gift from GlaxoSmithKline (Research Triangle Park, NC). Madin‐Darby canine kidney strain II cells, expressing human P‐gp after transfection with human MDR1 complementary DNA (MDCKII‐MDR1), were obtained from the Netherlands Cancer Institute (Amsterdam, The Netherlands).
Lee C.M., Zane N.R., Veal G, & Thakker D.R. (2019). Physiologically Based Pharmacokinetic Models for Adults and Children Reveal a Role of Intracellular Tubulin Binding in Vincristine Disposition. CPT: Pharmacometrics & Systems Pharmacology, 8(10), 759-768.
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2

Radiolabeled Compounds for Biological Assays

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[3H]-CQ (specific activity, 37 Ci mmol−1), [3H]-quinine (specific activity, 20 Ci mmol−1), [3H]-quinidine (specific activity, 20 Ci mmol−1), [3H]-vinblastine (specific activity, 7.8 Cimmol−1), [3H]-vincristine (specific activity, 5 Cimmol−1), [3H]-amantadine (specific activity, 33 Cimmol−1) and [3H]-piperaquine (specific activity, 15 Cimmol−1) were obtained from American Radiolabeled Chemicals, GE Healthcare or Quotient Biorsearch. Other chemicals were provided by Sigma-Aldrich.
Berger F., Gomez G.M., Sanchez C.P., Posch B., Planelles G., Sohraby F., Nunes-Alves A, & Lanzer M. (2023). pH-dependence of the Plasmodium falciparum chloroquine resistance transporter is linked to the transport cycle. Nature Communications, 14, 4234.
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