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Danusertib

Manufactured by Apexbio
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Sourced in United States

Danusertib is a small molecule inhibitor that targets Aurora kinases A, B, and C. It is a laboratory tool used for research purposes.

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Lab products found in correlation

Ldc000067, by Selleck Chemicals (1 mentions) Ro 3306, by Selleck Chemicals (1 mentions) K03861, by Selleck Chemicals (1 mentions) Bms 265246, by Selleck Chemicals (1 mentions) Carbenoxolone, by Merck Group (1 mentions) Mefloquine, by Merck Group (1 mentions) Arsenic trioxide, by Merck Group (1 mentions) Everolimus, by Apexbio (1 mentions)

2 protocols using danusertib

1

Preparation of Small Molecule Stocks

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BMS-265246 (SelleckChem, Houston, TX, USA), RO-3306 (SelleckChem), K03861 (SelleckChem), LDC000067 (SelleckChem), THZ1 (SelleckChem), Rigosertib (ApexBio, Houston, TX, USA) and Danusertib (ApexBio) powders were dissolved in DMSO to a stock concentration of 10 mM. The chemical stock solutions were stored as small aliquots at -80 °C.
Wang R., Yang J.F., Ho F., Robertson E.S, & You J. (2020). Bromodomain-Containing Protein BRD4 Is Hyperphosphorylated in Mitosis. Cancers, 12(6), 1637.
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2

Pharmacological Interventions in Cancer Models

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The administration of Carbenoxolone, Mefloquine and Danusertib
followed previous reports (Fraedrich et al.,
2012; Keiser et al., 2011 (link);
Morecki et al., 1997 (link)) whereas the
dose of the two FDA-approved drugs, Everolimus and Arsenic trioxide were
adjusted from clinical human dose by FDA guidance: mouse dose(mg/kg)=human
dose X mouse Km (~37) / mouse Km (~3). Carbenoxolone (CBX,
C4790 Sigma) was injected i.p. daily at the dosage of 30 mg/kg. Mefloquine
(MEFL, 1379059 Sigma) was administrated once weekly by oral gavage at the
dosage of 50 mg/kg. Danusertib (A4116, ApexBio) were injected i.p. daily at
the dosage of 15 mg/kg. Arsenic trioxide (A1010, Sigma) was injected i.p.
daily at the dosage of 1.9 mg/kg (transferred from 0.15 mg/kg/day for
human). Everolimus (A8169, ApexBio) was administrated daily by oral gavage
at the dosage of 1 mg/kg. For IIA model, all drug treatments were
administrated from the day of injection till the end of experiment unless
specifically stated. For spontaneous model, treatments were administrated
after resection of primary tumors till the end of experiment.
Wang H., Tian L., Liu J., Goldstein A., Bado I., Zhang W., Arenkiel B.R., Li Z., Yang M., Du S., Zhao H., Rowley D.R., Wong S.T., Gugala Z, & Zhang X.H. (2018). The osteogenic niche is a calcium reservoir of bone micrometastases and confers unexpected therapeutic vulnerability. Cancer cell, 34(5), 823-839.e7.
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