Fluoxetine (#H6995, Bosche Scientific), citalopram (#C505000, Toronto Research Chemicals), paroxetine (#2141, Tocris), fluvoxamine (#1033), venlafaxine (#2917, Tocris), reboxetine (#1982, Tocris), imipramine (#I7379-5G, Sigma–Aldrich), clomipramine (#C7291, Sigma–Aldrich), desipramine (#3067, Tocris), phenelzine (#P6777, Sigma–Aldrich), rolipram (#R6520, Sigma–Aldrich), ketamine (#3131, Tocris), 2R, 6R-Hydroxynorketamine and 2S, 6S-Hydroxynorketamine (#6094 and #6095, respectively, Tocris), carbamazepine (#4098, Tocris), chlorpromazine (#C8138, Sigma–Aldrich), flupenthixol (#4057, Tocris), and pimozide (#0937, Tocris) were investigated in this study. The compounds were dissolved in dimethyl sulfoxide (DMSO) that was also used as a vehicle in all the experiments. Concentrations tested (Table 1 ) were selected based on earlier in vitro studies from our research group (Fred et al., 2019 (link); Casarotto et al., 2021 (link)) and other laboratories (Johansen et al., 2015 (link)).
Fluvoxamine
Manufactured by Bio-Techne
Fluvoxamine is a laboratory reagent manufactured by Bio-Techne. It is a selective serotonin reuptake inhibitor (SSRI) that can be used in research applications. The core function of Fluvoxamine is to modulate serotonin levels in biological systems.
Automatically generated - may contain errors
Lab products found in correlation
Chlorpromazine, by Merck Group (1 mentions)
Rolipram, by Merck Group (1 mentions)
Reboxetine, by Bio-Techne (1 mentions)
Phenelzine, by Merck Group (1 mentions)
Clomipramine, by Merck Group (1 mentions)
Flupenthixol, by Bio-Techne (1 mentions)
Ketamine, by Bio-Techne (1 mentions)
Carbamazepine, by Bio-Techne (1 mentions)
Venlafaxine, by Bio-Techne (1 mentions)
Imipramine, by Merck Group (1 mentions)
Desipramine, by Bio-Techne (1 mentions)
Pimozide, by Bio-Techne (1 mentions)
Nisoxetine, by Bio-Techne (1 mentions)
3h dopamine, by PerkinElmer (1 mentions)
3h serotonin, by PerkinElmer (1 mentions)
125i rti 55, by PerkinElmer (1 mentions)
Citalopram, by Bio-Techne (1 mentions)
3h norepinephrine, by PerkinElmer (1 mentions)
C57bl 6j mice, by Jackson ImmunoResearch (1 mentions)
Prism 5, by GraphPad (1 mentions)
2 protocols using fluvoxamine
1
Evaluation of Antidepressant Compounds
2
Molecular Modeling of Neurotransmitter Binding
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Molecular modeling was performed using MOE
v2010 and v2011.10 software from Chemical Computing Group (Montreal,
Quebec, CA). The radioligands [3H]serotonin (∼28
Ci/mmol), [3H]dopamine (∼26 Ci/mmol), [3H]norepinephrine (∼26 Ci/mmol), and [125I]RTI-55
(∼2200 Ci/mmol) were obtained from PerkinElmer Life and Analytical
Sciences (Foster City, CA). Nonradioactive citalopram, mazindol, nisoxetine,
and fluvoxamine were obtained from Tocris Bioscience (Ellisville,
MO). Virtual screening hit compounds were purchased from Ambinter
(Orleans, FR). C57BL/6J mice were obtained from The Jackson Laboratory
(Bar Harbor, ME). Data analysis was performed using GraphPad Prism
5.0 (GraphPad Software, San Diego, CA).
v2010 and v2011.10 software from Chemical Computing Group (Montreal,
Quebec, CA). The radioligands [3H]serotonin (∼28
Ci/mmol), [3H]dopamine (∼26 Ci/mmol), [3H]norepinephrine (∼26 Ci/mmol), and [125I]RTI-55
(∼2200 Ci/mmol) were obtained from PerkinElmer Life and Analytical
Sciences (Foster City, CA). Nonradioactive citalopram, mazindol, nisoxetine,
and fluvoxamine were obtained from Tocris Bioscience (Ellisville,
MO). Virtual screening hit compounds were purchased from Ambinter
(Orleans, FR). C57BL/6J mice were obtained from The Jackson Laboratory
(Bar Harbor, ME). Data analysis was performed using GraphPad Prism
5.0 (GraphPad Software, San Diego, CA).
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!