Pd98059

Silica (S5631; silicon dioxide) was purchased from Sigma Aldrich (St, Louis, Mo, USA). ALLN, MG132, U0126 were provided by Calbiochem (Darmstadt, Hessen, Germany). PD98059 was purchased from Stressgen (San Diego, CA, USA). GN-25 was provided by Dr. Song GY (Chungnam National University) [37 (link)]. A549, AGS, H1299, H28, H2452 and HEK293 cell lines were obtained from American Type culture collection (ATCC, Manassas, VA, USA) and maintained in RPMI-1640 or DMEM containing 10% FBS and antibiotics. NSCLC cell lines (NCI-H23, NCI-H322, NCI-H358, NCI-H460) and lung fibroblast cell lines (WI-26, L132) were kindly provided by Dr. Kim S (Seoul National University). SCLC cell lines (NCI-H69, NCI-H146, NCI-H209) were purchased from Korean Cell line Bank (KCLB, Seoul, Korea) and maintained in RPMI-1640 containing 10% FBS and antibiotics. HCT116 and its isogenic p53−/− cell lines were obtained from Dr. Vogelstein B (Johns Hopkins University) and maintained in RPMI-1640 containing 10% FBS and antibiotics.