All participants were administered 111 ± 10% MBq I-123-MIBG via slow intravenous injection. Potassium iodate tablets (170 mg) were given before and after injection to minimize uptake of free iodine by the thyroid. Images were acquired on a dual headed Siemens Symbia Intevo or Siemens Symbia T series gamma camera (Siemens Healthcare, Munich, Germany) with medium energy low penetration (MELP) collimators. Ten minute anterior planar images were acquired at 4 h (± 30 min) after injection. SPECT imaging was carried out immediately after the planar image with the subject in the supine position with arms raised if possible; however the majority of controls (19/31) and patients (7/15 AD; 13/17 DLB) were scanned with their arms by their sides. Due to patient comfort it was not possible to complete SPECT imaging, even with arms down, for two of the 17 DLB patients, both of whom had low uptake on planar imaging. For planar imaging the energy window was 159 keV ± 10%, matrix size was 128 × 128 and no zoom was applied. SPECT images were acquired in H mode over 360 degrees with 120 projections of 20 s using a non-circular autocontoured orbit. The energy window was 159 keV ± 7.5%, matrix size 64 × 64, and zoom 1.64.
Symbia t series
Manufactured by Siemens
The Symbia T series is a line of medical imaging systems developed by Siemens. The core function of these systems is to provide advanced diagnostic capabilities through the integration of single-photon emission computed tomography (SPECT) and computed tomography (CT) technologies.
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Lab products found in correlation
2 protocols using symbia t series
1
I-123-MIBG Imaging in Dementia
2
I-123-MIBG Cardiac Imaging Protocol for DLB Diagnosis
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Subjects were administered 111 MBq I-123-MIBG via slow intravenous injection. Potassium iodate tablets (170mg) were given before and after injection for thyroid blockade. Ten minute anterior planar images were acquired at 20 minutes ("early") and 4 hours (± 30 minutes, "delayed"). Images were acquired on a Siemens Symbia T series or Siemens Symbia Intevo gamma camera with medium energy low penetration (MELP) collimators and processed on a Hermes workstation. Medium energy collimators are recommended for cardiac MIBG imaging by the EANM task group on standardisation [36] since they minimise septal penetration of the high energy photons that reduce image contrast. The energy window was 159 keV ± 10%, matrix size was 128 x 128 and no zoom was applied. The same settings were applied when participating in the European phantom calibration study [22] . We used the phantom calibration results for our centre to apply a correction factor to the HMR cut-off for DLB diagnosis determined by Yoshita et al. [17] . This small correction increases the cut-off for both gamma cameras from 2.10 to 2.25.
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