All PAHs were kindly provided by Dr. Albrecht Seidel (Biochemical Institute for Environmental Carcinogens, Prof. Dr. Gernot Grimmer Foundation, Großhansdorf, Germany), dissolved in DMSO with a final concentration of 10 mM and stored at −80 °C. Atorvastatin calcium salt and S-mephenytoin were purchased from Toronto Research Chemicals (North York, ON, Canada). Amodiaquine dihydrochloride dehydrate, bupropion hydrochloride, and tolbutamide were obtained from Supelco (Bellefonte, PA, USA). Phenacetin and propafenone hydrochloride were from Sigma-Aldrich (Taufkirchen, Germany). All other chemicals were purchased from Merck (Darmstadt, Germany) or Sigma-Aldrich (Taufkirchen, Germany) in the highest available purity and used as received.
S mephenytoin
Manufactured by LGC
Sourced in Canada
S-mephenytoin is a laboratory reagent used as a reference standard. It is a chemical compound that can be used for various analytical and research purposes.
Automatically generated - may contain errors
Lab products found in correlation
Phenacetin, by Merck Group (2 mentions)
Midazolam, by LGC (2 mentions)
Propafenone hydrochloride, by Merck Group (1 mentions)
Potassium dihydrogen phosphate, by Thermo Fisher Scientific (1 mentions)
Magnesium chloride, by Merck Group (1 mentions)
4 nitrocatechol, by Merck Group (1 mentions)
1 oh midazolam, by Merck Group (1 mentions)
4 oh midazolam, by Merck Group (1 mentions)
4 oh mephenytoin, by Merck Group (1 mentions)
4 oh diclofenac, by Merck Group (1 mentions)
Benzydamine n oxide, by Merck Group (1 mentions)
Dimethyl sulfoxide (dmso), by Merck Group (1 mentions)
Formic acid, by Merck Group (1 mentions)
Dipotassium hydrogen phosphate, by Merck Group (1 mentions)
Midazolam, by Lipomed (1 mentions)
Dextrorphan, by Merck Group (1 mentions)
Dehydronifedipine, by LGC (1 mentions)
Nifedipine, by Merck Group (1 mentions)
Chlorzoxazone, by Merck Group (1 mentions)
Dextromethorphan, by Merck Group (1 mentions)
4 protocols using s mephenytoin
1
Characterization of PAH Standard Solutions
2
Comprehensive Compound Library Analysis
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Albendazole, 1-OH-albendazole, benzydamine, phenacetin, acetaminophen, bufuralol, flutamide, diclofenac, and paclitaxel were obtained from the AstraZeneca compound library. 2-OH-bupropion, 1-OH-bufuralol, 1-OH-midazolam, 4-OH-midazolam, 4-OH-mephenytoin, 4-OH-diclofenac, 2-OH-flutamide, benzydamine N-oxide, 4-nitrocatechol, β-Nicotinamide adenine dinucleotide hydrate (NADPH) and DMSO were obtained from Sigma (St. Louis, MO, USA). Bupropion was obtained from Kemprotec Limited (Smailthorn, Carnforth, United Kingdom), midazolam from Lipomed (Cambridge, MA, USA), 6α-OH-paclitaxel from EMD Chemicals (San Diego, CA, USA), and S-mephenytoin from Toronto Research Chemicals (Toronto, ON, Canada). P-nitrophenol and potassium dihydrogen phosphate were obtained from Thermo Fisher Scientific (Gothenburg, Sweden) and dipotassium hydrogen phosphate and magnesium chloride were obtained from Merck (Kenilworth, NJ, USA). Formic acid (98–100%, analytical grade) was obtained from Merck (Darmstadt, Germany), acetonitrile from Rathburn (Walkerburn, UK), and ethanol from CCS Healthcare AB, Borlänge, Sweden. Deionized water was produced in an ELGA purification system (High Wycombe, UK).
3
Comprehensive Metabolic Enzyme Profiling
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Trans-resveratrol (tRVT, purity ≥ 99%), cis-resveratrol (cRVT, purity ≥ 98%), dehydronifedipine, diclofenac, 6-hydroxychlorzoxazone, 4-hydroxydiclofenac, 4-hydroxymephenytoin, S-mephenytoin, midazolam, mycophenolic acid (MPA), nifedipine, CDCA-24-acyl-β-glucuronide, 7-ethyl-10-hydroxy camptothecin (SN-38) glucuronide, MPA-β-d -glucuronide, and N-acetylserotonine (N-ASER)-β-d -glucuronide were obtained from Toronto Research Chemicals (Toronto, ON, Canada). Acetaminophen, amodiaquine, bupropion, chenodeoxycholic acid (CDCA), chlorzoxazone, dextromethorphan, dextrorphan, 6-hydroxybupropion, 7-hydroxycoumarin, N-ASER, N-desethylamodiaquine, naloxone, nifedipine, phenacetin, trifluoperazine (TFP), estrone-β-d -glucuronide, naloxone-β-d -glucuronide, and TFP-β-d -glucuronide were obtained from Sigma-Aldrich (St. Louis, MO, USA). SN-38 and 1′-hydroxymidazolam were provided by Santa Cruz Biotechnology (Dallas, TX, USA) and Cayman Chemicals (Ann Arbor, MI, USA), respectively. Pooled HLMs (XTreme 200) were purchased by XenoTech (Lenexa, KS, USA). rP450 (rCYP3A4, rCYP2E1, rCYP2C19, and rCYP1A2) were obtained from SPMED (Busan, Korea).
4
Metabolic profiling of human liver
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Chemicals Loperamide hydrochloride, oxethazaine, pa-* To whom correspondence should be addressed. e-mail: marisuke@med.showa-u.ac.jp paverine hydrochloride, pirenzepine hydrochloride hydrate, and trimebutine maleate were purchased from Wako Pure Chemical Industries, Ltd. (Osaka, Japan). Bufuralol and 1′-hydroxybufuralol were obtained from Gentest Co. (Waburn, MA, U.S.A.). S-Warfarin, S-mephenytoin, and midazolam were purchased from Toronto Research Chemicals Inc. (North York, ON, Canada), ENZO Life Sciences Inc. (New York, NY, U.S.A.), and Nippon Roche K.K. Inc. (Osaka, Japan), respectively. 7-Hydroxywarfarin, 1′-hydroxymidazolam and 4-hydroxymephenytoin were obtained from Daiichi Pure Chemicals Co., Ltd. (Tokyo, Japan). Ethoxyresorufin and resorfin were provided by Sigma-Aldrich Co. (St. Louis, MO, U.S.A.). All other chemicals and reagents used were of the highest, commercially available quality.
Human Liver Samples Human liver microsomes (a pooled fraction from 10 patients) were obtained from the nonprofit Human and Animal Bridging Research Organization (Chiba, Japan). The study protocol was approved by the Ethics Committee of Showa University School of Medicine.
Human Liver Samples Human liver microsomes (a pooled fraction from 10 patients) were obtained from the nonprofit Human and Animal Bridging Research Organization (Chiba, Japan). The study protocol was approved by the Ethics Committee of Showa University School of Medicine.
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