Biograph 16 pet ct scanner

Manufactured by Siemens

Sourced in Germany, United States

The Biograph 16 PET/CT scanner is a diagnostic imaging device that combines positron emission tomography (PET) and computed tomography (CT) technologies. It is designed to capture detailed, high-quality images of the body's anatomy and metabolic processes.

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Lab products found in correlation

Discovery ste pet ct scanner, by GE Healthcare (3 mentions) Biograph duo pet ct scanner, by Siemens (2 mentions) Biograph 40 truepoint pet ct scanner, by Siemens (1 mentions) Discovery st pet ct instrument, by GE Healthcare (1 mentions) Imeron 400, by Bracco (1 mentions)

Spelling variants of this product

Biograph 16 (75 citations) Biograph PET/CT scanner (30 citations) Siemens scanners (11 citations) PET/CT scanner (10 citations) CT scanners (7 citations) Biograph 16 scanner (6 citations) Biograph 16 PET/CT (3 citations) Biograph-16 PET scanner (2 citations) Biograph 16 (Hi-Rez) PET/CT scanner (2 citations)

14 protocols using biograph 16 pet ct scanner

Standardized PET/CT Imaging Protocol

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PET/CT scans were acquired after a single FDG injection. Patients fasted for 6 hours before the ¹⁸F-FDG injection (serum glucose level <180 mg/dL). FDG dose was corrected for body mass index at all centers. The scan was obtained from the subcranial region to the upper thigh (torso) 60 to 90 minutes after the injection. A low-dose CT acquisition without contrast enhancement (NE CT) was initiated first, followed by PET acquisition. Then, the CE CT scans were collected. Iterative reconstruction was done using ordered-subset expectation maximization software. The attenuation was corrected by NE CT. NE PET/CT was not performed at one institution, and CE PET/CT was used for attenuation correction in these patients (n=14).
The PET/CT machines used in this study were as follows: the Biograph TruePoint 40 PET/CT scanner (Siemens Medical Solutions, Knoxville, TN, USA) or the Biograph 16 PET/CT scanner (Siemens Medical Solutions), the Discovery ST PET/CT instrument (GE Medical Systems, Milwaukee, WI, USA), the Discovery ST PET/CT instrument (GE Medical Systems), the Discovery VCT PET/CT instrument (GE Medical Systems), and the Gemini TF (Philips-ADAC Medical Systems, Cleveland, OH, USA). The workstations used for reconstruction were the Syngo multimodality workplace, Exeleris Advanced Workstation 4.4 (GE Medical Systems).

Chong A., Ha J.M., Han Y.H., Kong E., Choi Y., Hong K.H., Park J.H., Kim S.H, & Park J.M. (2016). Preoperative Lymph Node Staging by FDG PET/CT With Contrast Enhancement for Thyroid Cancer: A Multicenter Study and Comparison With Neck CT. Clinical and Experimental Otorhinolaryngology, 10(1), 121-128.

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FDG-PET/CT Imaging Protocol for Oncology Studies

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Patients fasted for at least six hours before FDG injection (370–444 MBq). Serum glucose level was measured before FDG injection. Scanning was performed 50–70 min after injection of FDG using a Biograph Duo PET/CT scanner (Siemens Healthcare, Erlangen, Germany) or a Biograph 16 PET/CT scanner (Siemens Healthcare, Erlangen, Germany). Patients were asked to rest before acquisition of PET/CT images. Before the PET scan, a low-dose CT scan (5 mm slices) at an interval of 5 mm was performed for attenuation correction and anatomic co-registration. Intravenous contrast material was not used. PET images were acquired using an acquisition time of 3 min per table position, with an approximate 28% overlap. Images were obtained from the skull base to the proximal thigh with the patient in supine position. Images were reconstructed by a 3D row-action maximum-likelihood algorithm for iterative and ordered-subset expectation maximization using the Biograph system. PET images were corrected for attenuation using a CT-derived transmission map. Voxel size after reconstruction was 2.65 × 2.65 × 2.65 mm.

Jun S., Park J.G, & Seo Y. (2018). Accurate FDG PET tumor segmentation using the peritumoral halo layer method: a study in patients with esophageal squamous cell carcinoma. Cancer Imaging, 18, 35.

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PET/CT Imaging Protocol for Tumor Diagnosis

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All 109 patients were examined using a routine clinical protocol on an integrated PET/CT scanner (Biograph 16 PET/CT Scanner [Siemens Medical Solutions, Erlangen, Germany]). Patients were fasting for at least 12 hours. Sixty to ninety minutes after intravenous injection of a mean activity of 325 MBq (4 MBq or 108 μCi per kg body weight, range 224–426 MBq) [¹⁸F]FDG, a whole body PET/CT scanning (from the vertex of the skull to the groin), was performed in a 3D-mode (3 minutes per bed position). According to clinical indication, a low-dose or a diagnostic CT was performed. If a diagnostic CT was indicated, a nonionic iodinated X-ray contrast agent (Imeron 400, Bracco Imaging, Konstanz, Germany) was applied. Dosing and imaging procedures used were in accordance with German and European PET/CT guidelines for tumor imaging.^{[13 (link),14 ]}

Frille A., Steinhoff K.G., Hesse S., Grachtrup S., Wald A., Wirtz H., Sabri O, & Seyfarth H.J. (2016). Thoracic [18F]fluorodeoxyglucose uptake measured by positron emission tomography/computed tomography in pulmonary hypertension. Medicine, 95(25), e3976.

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Assessing Brown Adipose Tissue Function

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Forty-eight to 72 h after the shivering threshold test, participants went to the Hospital Virgen de las Nieves in Granada (Spain) for the assessment of BAT volume, ¹⁸F-FDG uptake, and radiodensity. After resting in a warm room, they were placed in a cool room (19.5–20 °C) wearing the same cooling vest with the water temperature set at the personalized temperature, as explained above. After the first hour of cold exposure, the participants received an injection of ¹⁸F-FDG (~185 MBq) and the water temperature was increased by 1 °C to avoid shivering. The water temperature was also slightly increased at any time participants reported shivering. One hour later, they were subjected to ¹⁸F-FDG-PET/CT scanning in the supine position using a Siemens Biograph 16 PET/CT scanner (Siemens, Erlangen, Germany). Image acquisition covered an area of two BED positions from the atlas vertebra to thoracic vertebra 6, approximately. The natural calendar day when the baseline, and post-intervention PET/CT scan were performed was recorded from day 1 (January 1st) to day 365/366 (December 31^st).

Martinez-Tellez B., Sanchez-Delgado G., Acosta F.M., Alcantara J.M., Amaro-Gahete F.J., Martinez-Avila W.D., Merchan-Ramirez E., Muñoz-Hernandez V., Osuna-Prieto F.J., Jurado-Fasoli L., Xu H., Ortiz-Alvarez L., Arias-Tellez M.J., Mendez-Gutierrez A., Labayen I., Ortega F.B., Schönke M., Rensen P.C., Aguilera C.M., Llamas-Elvira J.M., Gil Á, & Ruiz J.R. (2022). No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial. Nature Communications, 13, 5259.

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FDG-PET/CT Imaging Protocol for Oncology

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All patients fasted for at least 6 hours before intravenous injection of F-18 FDG and blood glucose levels of all patients were found to be below 126 mg/dl [14 (link)]. Approximately 5.5 MBq of F-18 FDG per kilogram of body weight was administered intravenously. Scanning was performed about 60 minutes after FDG administration. Images were obtained from the base of the skull to the proximal thigh using either a Biograph TruePoint 40 PET/CT scanner (Siemens Medical Solutions, Knoxville, Tennessee, USA) or a Biograph 16 PET/CT scanner (Siemens Medical Solutions). A CT scan was obtained first using a continuous spiral technique (120 kVp, 160 mA, 0.5 seconds rotation time). A PET scan was then acquired in a three-dimensional mode for 2.5 minutes in each bed position. The PET data obtained were reconstructed iteratively using an ordered-subset expectation maximization algorithm (128 × 128 matrix, 3.27 mm slice thickness, subset: 21, iterations: two). Acquisition and processing protocols of F-18 FDG PET/CT had not altered during the study duration. All F-18 FDG PET images were to be reported in compliance with the hospital′s own reporting form.

Han Y.H., Jeong H.J, & Lim S.T. (2021). Clinical and metabolic parameters for predicting disease progression of gallbladder adenocarcinoma. Nuclear Medicine Communications, 43(1), 42-48.

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FDG-PET Imaging of Mediastinal Tumors

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Patients fasted for at least 6 h before FDG-PET examination. Intravenous ¹⁸F-FDG was administered at a dose of 5 MBq/kg. Sixty minutes after the injection, data was acquired using a Discovery STE PET/CT scanner (GE Healthcare) or a Biograph 16 PET/CT scanner (Siemens). Three-dimensional emission scanning was performed from the groin area to the top of the skull. The FDG uptake in the anterior mediastinal tumor was recorded.

Yajima T., Mogi A., Shimizu K., Kosaka T., Ohtaki Y., Obayashi K., Nakazawa S., Nakajima T., Tsushima Y, & Shirabe K. (2020). Quantitative analysis of metabolic parameters at 18F-fluorodeoxyglucose positron emission tomography in predicting malignant potential of anterior mediastinal tumors. Oncology Letters, 19(3), 1865-1871.

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FDG-PET/CT Imaging Standardized Protocol

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All patients in the study fasted for at least six hours before intravenous FDG administration. The dose range of intravenously injected FDG was 370–444 MBq, depending on patient weight. PET/CT images were acquired using a Biograph Duo PET/CT scanner (Siemens Healthcare) or a Biograph 16 PET/CT scanner (Siemens Healthcare). Prior to the PET scan, a CT scan (5 mm slice thickness) at an interval of 5 mm was acquired without contrast enhancement for attenuation correction.

Usefulness of 18F-FDG PET/CT and Multiphase CT in the Differential Diagnosis of Hepatocellular Carcinoma and Combined Hepatocellular Carcinoma-Cholangiocarcinoma. (2020). Journal of the Korean Society of Radiology (Taehan Yŏngsang Ŭihakhoe chi), 81(6), 1424-1435.

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FDG PET/CT Imaging Protocol

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The patients fasted for 6 h before the intravenous injection of ¹⁸F-FDG (5 MBq/kg). FDG PET/CT images were acquired 1 h after injection with the Discovery STE PET/CT scanner (GE Healthcare, Milwaukee WI) and Biograph 16 PET/CT scanner (Siemens, Malvem, PA). All PET images were independently interpreted by two experienced doctors of nuclear medicine. Functional images of the SUV were produced for a semiquantitative analysis. The SUV was defined as follows: SUV = radioactive concentration in the region of interest (MBq/g)/injected dose (MBq)/patient’s body weight (g). The SUVmax was defined as the peak SUV within the region of interest.

Yanagawa T., Saito K., Kiyohara H., Ohno T., Nakano T, & Takagishi K. (2015). Monitoring bone and soft-tissue tumors after carbon-ion radiotherapy using 18F-FDG positron emission tomography: a retrospective cohort study. Radiation Oncology (London, England), 10, 259.

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Pulmonary SERT Availability Assessment

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Pulmonary SERT availability was assessed after intravenous injection of SERT-selective [¹¹C] 3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile ([¹¹C]DASB) with averaged 495 ± 6 MBq using an integrated PET/CT scanner (Biograph 16 PET/CT Scanner [Siemens Medical Solutions, Erlangen, Germany]). The dynamic acquisition was performed over 30 minutes (min) and comprised 30 measuring points (12 × 15 s [seconds], 2 × 30 s, 6 × 60 s, 10 × 120 s). A low-dose CT of the lung was performed in each subject for anatomic coregistration and attenuation correction. The radioactivity in blood was measured at 10, 15, 20, 25, and 30-min post injection (p.i.) in each participant using a Cobra gamma counter (Packard Instrument Company, Meriden, CT, USA) and decay was corrected to the start time of the PET/CT scan (Fig. 1(b, c)).

Frille A., Rullmann M., Becker G.A., Patt M., Luthardt J., Tiepolt S., Wirtz H., Sabri O., Hesse S, & Seyfarth H.J. (2020). Increased pulmonary serotonin transporter in patients with chronic obstructive pulmonary disease who developed pulmonary hypertension. European Journal of Nuclear Medicine and Molecular Imaging, 48(4), 1081-1092.

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Measuring Brown Adipose Tissue Activity

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The cooling protocol used and the quantification of the BAT volume and activity were as previously reported [14, 16] (link). Briefly, subjects sat in a cool room (19.5-20 °C) wearing a water-perfused cooling vest (Polar Products Inc., Stow, OH, USA). The water temperature was reduced from 16.6 °C at ~2.2 °C per 10 min until they began shivering. After 48-72 h had elapsed, they went to the Hospital Virgen de las Nieves, where they were again placed in a cool room (19.5-20 °C) and wore the same cooling vest but with the water temperature set ~4 °C above their earlier shivering threshold test result for 2 h. After the first hour, the subjects received an injection of [ 18 F] FDG (1 85 MBq) and the water temperature was increased by 1 °C to avoid visually detectable shivering. One hour later, they were subjected to PET/CT using a Siemens Biograph 16 PET/CT scanner (Siemens, Erlangen, Germany), scanning two BEDs from the atlas vertebra to thoracic vertebra 6 (approximately).

Martinez-Tellez B., Sanchez-Delgado G., Boon M.R., Rensen P.C.N., Llamas-Elvira J.M, & Ruiz J.R. (2020). Distribution of Brown Adipose Tissue Radiodensity in Young Adults: Implications for Cold [¹⁸F]FDG-PET/CT Analyses. Molecular imaging and biology, 22(2).

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