Inveon micropet scanner

Manufactured by Siemens

Sourced in Germany, United States

The Inveon microPET scanner is a high-performance preclinical imaging system designed for small animal research. It is capable of producing high-resolution PET (Positron Emission Tomography) images to support various scientific applications.

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Lab products found in correlation

Isoflurane, by Abbott (3 mentions) Inveon research workplace irw2.0.0.1050, by Siemens (2 mentions) Inveon, by Siemens (2 mentions) Microct, by MILabs (2 mentions) Pmod software, by PMOD Technologies (1 mentions) Vivoquant ver 4, by Invicro (1 mentions) Crtac ncr foxn1nu mice, by Taconic Biosciences (1 mentions) Potassium perchlorate, by Merck Group (1 mentions) Wallac 1470 wizard, by PerkinElmer (1 mentions) Asipro vm micro pet analysis software, by Siemens (1 mentions) C18 column, by Agilent Technologies (1 mentions) Automatic gamma counter, by Hidex (1 mentions)

Close spelling variants of this product

Inveon microPET/CT scanner Inveon microPET/microCT rodent scanner Inveon microPET/microCT scanner Inveon microPET/microCT hybrid scanner Inveon microPET/microCT rodent model scanner Inveon microPET Inveon scanner Inveon Siemens scanners

44 protocols using inveon micropet scanner

PET Brain Glucose and Blood Flow Imaging

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For the brain glucose metabolism assessment, a 10-min static PET scan of brains was performed. After completing the behavioral assays, mice from different experimental groups were injected intravenously with 5.4–8.1 MBq (146–220 μCi) of [¹⁸F]FDG. Around 2 h after injection, brains were dissected and static 10-min PET images were obtained using an Inveon MicroPET scanner (Siemens).
For the brain blood flow assessment, a 2-min dynamic PET scan of mice was performed. MI and SHAM mice were injected intravenously with 4.0–4.3 MBq (109–117 mCi) of FDG, and 2-min dynamic PET scans were obtained using an Inveon MicroPET scanner (Siemens)^{86 (link)–88 (link)}. The body temperature of mice was maintained at 37 °C. MicroCT (MILabs) was used for anatomical references. Regions of interest were manually drawn over the hippocampus. All PET images were reconstructed using an 3D-OSEM algorithm with three iterations in a 256 × 256 matrix (Inveon, Siemens) and analyzed using VivoQuant version 4 (Invicro). Decay correction was applied to all PET data.

Dridi H., Liu Y., Reiken S., Liu X., Argyrousi E.K., Yuan Q., Miotto M.C., Sittenfeld L., Meddar A., Soni R.K., Arancio O., Lacampagne A, & Marks A.R. (2023). Heart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2. Nature Neuroscience, 26(8), 1365-1378.

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In Vivo Imaging of Alzheimer's Disease in Transgenic Mice

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Three seven-month old double transgenic AD mice from B6C3-Tg (APPswe, PSEN1dE9) 85 Dbo/J mice were acquired from Guangdong Medical Laboratory Animal Center. Inveon micro-PET scanner (Siemens) was used for the ¹⁸F-FP-DPAZn2 PET-CT study. Each animal was injected with 3.7-7.4 MBq of ¹⁸F-FP-DPAZn2 in 100–200 μL of saline. The PET-CT scan was performed according to the reference [27 ].

Wen F., Nie D., Hu K., Tang G., Yao S, & Tang C. (2017). Semi-automatic synthesis and biodistribution of N-(2-18F-fluoropropionyl)-bis(zinc (II)-dipicolylamine) (18F-FP-DPAZn2) for AD model imaging. BMC Medical Imaging, 17, 27.

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Non-invasive CD8 T Cell Tracking

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Non-invasive immuno-PET tracking CD8 T cells in vivo was performed using ⁸⁹Zr-desferrioxamine-labeled anti-CD8 cys-diabody (cDb) at the UCLA Preclinical Imaging Technology Center, Crump Institute^{30 (link)}. For microPET imaging, 150 µL doses containing Zr-89 radiolabeled cDb were prepared in saline for i.v. injection. Mice were anesthetized using 2% isoflurane and microPET scans were acquired using an Inveon microPET scanner (Siemens, Munich, Germany) followed by microCT scan (ImTek, Wedesboro, NJ). MicroPET images were reconstructed using non-attenuation or scatter corrected maximum a posteriori (MAP) reconstruction and AMIDE was used for image analysis and display^{31 (link)}. At 24 h post-injection, mice were euthanized, the organs and blood were collected, weighed and the radioactivity was counted to assess CD8 T cells biodistribution. The percent-injected dose per gram of tissue (%ID/g) was calculated using a standard containing one percent of the injected dose^{31 (link)}.

Parisi G., Saco J.D., Salazar F.B., Tsoi J., Krystofinski P., Puig-Saus C., Zhang R., Zhou J., Cheung-Lau G.C., Garcia A.J., Grasso C.S., Tavaré R., Hu-Lieskovan S., Mackay S., Zalevsky J., Bernatchez C., Diab A., Wu A.M., Comin-Anduix B., Charych D, & Ribas A. (2020). Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist. Nature Communications, 11, 660.

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In Vivo PET Imaging of rGO-AuNRVe

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For the in vivo PET imaging experiment, 200 μL of ⁶⁴Cu-labeled rGO-AuNRVe was intravenously injected into the mice when the tumor volume reached ~60 mm³. The whole-body PET scans and data calculation were processed by using an Inveon Micro PET scanner (Siemens Medical Solutions) at predetermined time intervals after injection.

Song J., Yang X., Jacobson O., Lin L., Huang P., Niu G., Ma Q, & Chen X. (2015). Sequential Drug Release and Enhanced Photothermal and Photoacoustic Effect of Hybrid Reduced Graphene Oxide-Loaded Ultrasmall Gold Nanorod Vesicles for Cancer Therapy. ACS nano, 9(9), 9199-9209.

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Radiolabeled Peptide Imaging Protocol

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The equipment utilized in the current study included: an HM-67 medical cyclotron (Sumitomo, Japan); an AC210S electronic balance (Sartorius, Germany); a Bond Elut (02011) C18 column (Agilent Technologies, USA); a Waters 600 high-performance liquid chromatography (HPLC) and XBridge separation column (Waters, XBridge, USA); a TR610 radioactivity detector (Perkin-Elmer, USA); an animal 50262 anesthesia machine (Stoelting, USA); an Inveon micro-PET scanner (Siemens, USA); and a 1470 Wizard gamma radioimmunoassay counter (Perkin-Elmer, USA).
All chemicals were obtained from commercial sources and used without further purification. Acetonitrile, trifluoroacetic acid (TFA), aluminum chloride, ethanol, and glacial acetic acid were purchased from Chemical Reagent (Sinopharm). NOTA-Cyclo (Lys-Ala-His-Trp-Gly-Phe-Thr-Leu-Asp)-NH₂, whose chemical structure was shown in Fig 1 (see S1 Fig), was purchased from Chinese Peptide (Hangzhou, China). Isoflurane was obtained from Abbott Laboratories (Shanghai, China).

Liu Q., Pan D., Cheng C., Zhang D., Zhang A., Wang L., Jiang H., Wang T., Liu H., Xu Y., Yang R., Chen F., Yang M, & Zuo C. (2015). Development of a Novel PET Tracer [18F]AlF-NOTA-C6 Targeting MMP2 for Tumor Imaging. PLoS ONE, 10(11), e0141668.

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Radiolabeling of ZrMOF Nanoparticles for PET Imaging

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To the as-prepared ZrMOF-PEG nanoparticle solution, ⁶⁴Cu(Ac)2 (0.7 mCi) was added and incubated at 50 °C for 2 h. The labeling efficiency was monitored by TLC. After labeling, ⁶⁴Cu-ZrMOF was washed with water and resuspended in PBS buffer at a final concentration of 1 μCi / μL. ⁶⁴Cu-ZrMOF nanoparticles (100 μCi) were intravenously injected into the A431 tumor-bearing mice. Whole-body PET scans at different periods of time were collected from an Inveon Micro PET scanner (Siemens Medical Solutions). The data were analyzed by 3-dimensional regions of interest using (insert software used). Data were reported as %ID/g.

Liu Y., Gong C.S., Dai Y., Yang Z., Yu G., Liu Y., Zhang M., Lin L., Tang W., Zhou Z., Zhu G., Chen J., Jacobson O., Kiesewetter D.O., Wang Z, & Chen X. (2019). In situ polymerization on nanoscale metal-organic frameworks for enhanced physiological stability and stimulus-responsive intracellular drug delivery. Biomaterials, 218, 119365.

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In Vivo Ga-68 PET Imaging of Nanobodies

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MicroPET imaging was performed on an Inveon microPET scanner (SiemensMedical Solutions, Germany). Xenograft mice were injected intravenously with 4.0-5.0 MBq ⁶⁸Ga-NOTA-Nb109 and imaged (10 min) at 0.5, 1, 2, 4 hours post-injection. The mice were pre-treated with Sindilizumab (5 mg/kg) one day in advance in the blocking group. The mice were anesthetized with 1.5%–2% isoflurane in 0.5 L/min flow of oxygen. Dynamic images had been collected continuously in two hours. All the images were reconstructed using three-dimensional ordered subset expectation maximization (OSEM 3D/SP-MAP) without attenuation correction and then processed through the Siemens Inveon Research Workplace (IRW2.0.0.1050). The interest regions were drawn over both tumors and central organs, and the average signal levels in the regions were measured.

Qin S., Yu Y., Guan H., Yang Y., Sun F., Sun Y., Zhu J., Xing L., Yu J, & Sun X. (2021). A preclinical study: correlation between PD-L1 PET imaging and the prediction of therapy efficacy of MC38 tumor with 68Ga-labeled PD-L1 targeted nanobody. Aging (Albany NY), 13(9), 13006-13022.

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Longitudinal Tracking of Radiolabeled Cells

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Static microPET scans were performed on an Inveon microPET scanner (Siemens Medical Solutions, Erlangen, Germany). Dynamic microPET/MRI scans were performed on a 9.4 T Bruker BioSpec 94/30 USR with PET insert (Bruker Biospin, Ettlingen, Germany). In order to monitor and compare the changes of PET images by iron removal drugs. C57BL/6 mice were intravenously injected with 5 × 10⁶⁸⁹Zr‐radiolabeled bone marrow cells, 8 × 10⁵⁸⁹Zr‐radiolabeled MSCs, and 5 × 10⁶⁶⁸Ga‐radiolabeled bone marrow cells via the tail vein. The radioactivity of each mouse was 180−185, 80−90, and 3.3–3.7 MBq, respectively. For ⁶⁸Ga imaging, 10‐min‐long static PET scans were conducted at 2, 4, and 6 h p.i. For ⁸⁹Zr imaging, 10 min‐long static PET scans were performed at 30 min, 2, 4, 8, 24, and 48 h p.i.

Xu Q., Wang X., Mu Z., Zhou Y., Ding X., Ji X., Yan J., Pan D., Chen C., Xu Y., Wang L., Wang J., Wang G, & Yang M. (2024). Repurposing iron chelators for accurate positron emission tomography imaging tracking of radiometal‐labeled cell transplants. MedComm, 5(2), e473.

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Quantitative PET Imaging Protocol

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PET scans were performed using an Inveon microPET scanner (Siemens Medical Solutions, Germany). About 3.7 MBq of 68Ga labeled tracer was administered via tail vein injection under isoflurane anesthesia. The dynamic image acquisitions were continued from the beginning to 60 min after the administration. For each scan, regions of interest (ROIs) were drawn using vendor software (ASI Pro 5.2.4.0) on decay-corrected whole-body coronal images. The radioactivity concentrations (accumulation) were obtained from mean pixel values within the multiple ROI volume and then converted to MBq per milliliter. These values were then divided by the administered activity to obtain (assuming a tissue density of 1 g/ml) an image-ROI-derived percent injected dose per gram (%ID/g).

Zhu X., Zou W., Meng X., Ji J., Wang X., Shu H., Chen Y., Pan D., Wang K, & Zhou F. (2022). Elaiophylin Inhibits Tumorigenesis of Human Uveal Melanoma by Suppressing Mitophagy and Inducing Oxidative Stress via Modulating SIRT1/FoxO3a Signaling. Frontiers in Oncology, 12, 788496.

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Longitudinal PET Imaging of Intestine

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High-resolution PET imaging was performed using two identical small animal Inveon microPET scanner (Siemens Medical Solutions, Knoxville, USA) with a spatial resolution of 1.4 mm in the reconstructed images (field of view [FOV]: transaxial, 10 cm; axial, 12.7 cm).⁶³ (link) By applying iterative ordered subset expectation maximization (OSEM) 2D algorithm for reconstruction, list mode data were processed. Mice were anesthetized with 1.5% isoflurane (Abbott, Wiesbaden, Germany) vaporized with O₂ (1.5 L/min) and injected intravenously (i.v.) into the tail vein with 8.3 ± 1.3 MBq [¹⁸F]FDG. After tracer injection, animals were kept anesthetized for 60 min, in an anesthesia box, placed on a heating pad to maintain body temperature of animals during tracer uptake time. Shortly before the end of the uptake time, mice were placed in the FOV of the PET scanner on a warmed (37°C) scanner bed. Static (10-min) PET scans were performed on weeks 0, 4, 6, and 8 after T cell application. Data were corrected for decay, normalized to the injected activity, and analyzed using Pmod Software (PMOD Technologies, Zurich, Switzerland) by drawing regions of interest over the intestine.

Steimle A., Michaelis L., Di Lorenzo F., Kliem T., Münzner T., Maerz J.K., Schäfer A., Lange A., Parusel R., Gronbach K., Fuchs K., Silipo A., Öz H.H., Pichler B.J., Autenrieth I.B., Molinaro A, & Frick J.S. (2019). Weak Agonistic LPS Restores Intestinal Immune Homeostasis. Molecular Therapy, 27(11), 1974-1991.

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