B6 h 2b

Manufactured by Jackson ImmunoResearch

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B6 (H-2b) is a mouse strain that expresses the H-2b major histocompatibility complex (MHC) haplotype. It is commonly used in immunological research as a model for studying immune responses and disease processes.

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Lab products found in correlation

Balb c h 2d, by Jackson ImmunoResearch (3 mentions) B6.129s7 rag1tm1mom j mice, by Jackson ImmunoResearch (1 mentions) Balb c h 2d mice, by Jackson ImmunoResearch (1 mentions) B6 c tg cmv cre 1cgn j, by Jackson ImmunoResearch (1 mentions)

6 protocols using b6 h 2b

Murine Host Strain Comparison

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BALB/c (CD45.1 and CD45.2, H-2^d) and B6 (H-2^b) mice from Jackson Laboratories (Bar Harbor, ME) were housed in the animal facility at Center for Comparative Medicine, Northwestern University. All mice were used according to protocols approved by the Institutional Animal Care and Use Committee of Northwestern University.

Zhang Z., Qiu L., Yan S., Wang J.J., Thomas P.M., Kandpal M., Zhao L., Iovane A., Liu X.F., Thorp E.B., Chen Q., Hummel M., Kanwar Y.S, & Abecassis M.M. (2019). A clinically relevant murine model unmasks a “two‐hit” mechanism for reactivation and dissemination of cytomegalovirus after kidney transplant. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 19(9), 2421-2433.

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Transgenic Mice for Ovalbumin Study

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B6 (H-2^b) and BALB/c (H-2^d) were purchased from the Jackson Laboratory (Bar Harbor, ME). Spi6^−/− C57BL/6 (18 (link)), C57BL/6-Tg(CAG-OVA)916Jen/J transgenic mice expressing the membrane bound chicken ovalbumin on all cell surface and OT-I TCR transgenic mice (C57BL/6 background) express a transgenic TCR that recognizes the 8-mer SIINFEKL peptide derived from residues 257–264 of ovalbumin and OT1.Spi6^−/− mice were maintained in our animal facility. All animals were used at 6–10 weeks of age (20–25 g) and were housed in accordance with institutional and National Institutes of Health guidelines. The Harvard Medical School Animal Management Committee approved all animal experiments.

Azzi J., Ohori S., Ting C., Uehara M., Abdoli R., Smith B.D., Safa K., Solhjou Z., Lukyanchykov P., Patel J., McGrath M, & Abdi R. (2015). Serine Protease Inhibitor-6 Differentially Affects the Survival of Effector and Memory Alloreactive CD8-T Cells. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 15(1), 234-241.

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Heterotopic Heart Transplantation in Mice

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Male and female B6 (H2^b), and female B6.129S7-Rag1^tm1Mom/J mice were purchased from Jackson Laboratories (Bar Harbor, ME) for use at 8-12 weeks of age. Female C57BL/10NA;-(Tg)TCR Marilyn-(KO)Rag2 mice (H-2^b, Marilyn), were a generous gift from Polly Matzinger (National Institutes of Health, Bethesda, MD) and Olivier Lantz (INSERM, Paris, France). All animal studies were approved by the Cleveland Clinic institutional animal care and use committee.
Donor hearts were transplanted heterotopically into the abdomen of recipients as previously described (18).

Kaul A.M., Goparaju S., Dvorina N., Iida S., Keslar K.S., de la Motte C.A., Valujskikh A., Fairchild R.L, & Baldwin WM I.I.I. (2015). Acute and Chronic Rejection: Compartmentalization and Kinetics of Counterbalancing Signals in Cardiac Transplants. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 15(2), 333-345.

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Mouse Model for AhR Knockout

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Six- to 12-week-old male and female B6 (H-2b) and male BALB/c (H-2d) mice were obtained from The Jackson Laboratory (Bar Harbor, ME). AHR^−/− mice on a B6 background^{27 (link)} were bred and maintained under specific pathogen-free conditions. Animal experiments were carried out according to institutional guidelines.

Julliard W., Fechner J.H., Owens L., O'Driscoll C.A., Zhou L., Sullivan J.A., Frydrych L., Mueller A, & Mezrich J.D. (2017). Modeling the Effect of the Aryl Hydrocarbon Receptor on Transplant Immunity. Transplantation Direct, 3(5), e157.

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Murine Models for Immunological Studies

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Wild-type (WT) C57BL/6 (B6, H-2^b), B cell deficient C57BL/6 (μMT^−/−B6, H-2^b), hen egg lysozyme (HEL)–specific BCR transgenic C57BL/6 (MD4, H-2^b), OVA-transgenic C57BL/6 mice (OVA+, H-2^b), MHC class II variant C57BL/6 (BM12, H-2^b), OTII (H-2^b) and BALB/c (H-2^d) mice were purchased from Jackson Laboratory (Bar Harbor, ME). OBI mice (C57BL/6 background) were generously provided by Dr Hidde Ploegh, Whitehead Institute for Biomedical Research.^{17 (link)} All mice were housed under specific pathogen-free conditions in the animal facility of Massachusetts General Hospital. All protocols were approved by the Institutional Animal Care and Use Committee.

Kimura S., Rickert C.G., Kojima L., Aburawi M., Tanimine N., Fontan F., Deng K., Tector H., Mi Lee K., Yeh H, & Markmann J.F. (2019). Regulatory B cells require antigen recognition for effective allograft tolerance induction. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 20(4), 977-987.

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Mouse Strains for Immune Cell Studies

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Female B6 (H-2^b) and BALB/c (H-2^d) mice, ages 4–9 weeks, were purchased from The Jackson Laboratory or Harlan Laboratories. B6.C-Tg(CMV-cre)1Cgn/J and C57BL/6-Tg(CAG-OVAL)916Jen/J mice, ages 8–9 weeks, were purchased from The Jackson Laboratory. B6 were bred with 2W-OVA.BALB/c mice to obtain 2W-OVA.F1 mice, and B6.C-Tg(CMV-cre)1Cgn/J mice were bred with 2W-OVA.BALB/c mice to obtain Cre+2W-OVA.F1 mice. TCR75 TCR-Tg mice were obtained from R. Pat Bucy (University of Alabama at Birmingham, Birmingham, Alabama, USA) and crossed to CD45.1 mice in the animal facilities of the University of Chicago. Foxp3-GFP C57BL/6 mice were purchased from The Jackson Laboratory and crossed to CD45.1 mice in the animal facilities of the University of Chicago.

Andrade M.S., Young J.S., Pollard J.M., Yin D., Alegre M.L, & Chong A.S. (2022). Linked sensitization by memory CD4+ T cells prevents costimulation blockade–induced transplantation tolerance. JCI Insight, 7(11), e159205.

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