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Il10rb mice

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IL10rb−/− mice are genetically modified mice that lack the interleukin-10 receptor beta (IL-10Rβ) subunit. This receptor is essential for the signaling of interleukin-10 (IL-10), an important anti-inflammatory cytokine. These mice can be used to study the role of IL-10 signaling in various biological processes.

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Lab products found in correlation

Casp1 11 mice, by Jackson ImmunoResearch (2 mentions) Gsdmd mice, by Jackson ImmunoResearch (2 mentions) Stinggt, by Jackson ImmunoResearch (2 mentions) Il 10 mice, by Jackson ImmunoResearch (2 mentions) Batf3, by Jackson ImmunoResearch (2 mentions) Nod scid gamma (nsg), by Jackson ImmunoResearch (2 mentions) C57bl 6j, by Jackson ImmunoResearch (2 mentions) Balb cj, by Jackson ImmunoResearch (2 mentions) Rag1 mice, by Taconic Biosciences (2 mentions) Ifnar1, by Jackson ImmunoResearch (1 mentions)

5 protocols using il10rb mice

1

Genetically Engineered Mouse Models

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C57BL/6J (RRID:IMSR_JAX:000664), Balb/cJ (RRID: IMSR_JAX:000651), Batf3−/− (RRID: IMSR_JAX:013755), and Rag1−/− (RRID: IMSR_JAX:002216), NSG (RRID: IMSR_JAX:005557), Stinggt (RRID: IMSR_JAX:017537), IL10−/− mice (RRID: IMSR_JAX:002251), IL10rb−/− mice (RRID: IMSR_JAX:005027), Gsdmd−/− mice (RRID: JAX032663) and Casp1/11−/− mice (RRID: JAX016621) were obtained from The Jackson Laboratory. Havcr2−/− mice were gifted by Dr. Binfeng Lu, and Timd4−/− mice were gifted from Dr. Vijay K. Kuchroo. All mice were maintained and bred under in specific pathogen-free conditions animal facilities at UPMC Hillman Cancer center. All mice were used for experiments at 8-10 weeks of age (age and sex matched, both sexes used). All animal experiments were performed under protocols approved by University of Pittsburgh Animal Care and Use Committee. All mice were housed in specific-pathogen-free conditions at an ambient temperature of 20–26°C and humidity of 30–70% with a 12 h:12 h light:dark cycle before use.
Wang W., Wu S., Cen Z., Zhang Y., Chen Y., Huang Y., Cillo A.R., Prokopec J.S., Quarato G., Vignali D.A., Stewart-Ornstein J., Li S., Lu B, & Gong Y.N. (2022). Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy. Cell reports, 41(5), 111582.
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2

Genetically Engineered Mouse Models

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C57BL/6J (RRID:IMSR_JAX:000664), Balb/cJ (RRID: IMSR_JAX:000651), Batf3−/− (RRID: IMSR_JAX:013755), and Rag1−/− (RRID: IMSR_JAX:002216), NSG (RRID: IMSR_JAX:005557), Stinggt (RRID: IMSR_JAX:017537), IL10−/− mice (RRID: IMSR_JAX:002251), IL10rb−/− mice (RRID: IMSR_JAX:005027), Gsdmd−/− mice (RRID: JAX032663) and Casp1/11−/− mice (RRID: JAX016621) were obtained from The Jackson Laboratory. Havcr2−/− mice were gifted by Dr. Binfeng Lu, and Timd4−/− mice were gifted from Dr. Vijay K. Kuchroo. All mice were maintained and bred under in specific pathogen-free conditions animal facilities at UPMC Hillman Cancer center. All mice were used for experiments at 8-10 weeks of age (age and sex matched, both sexes used). All animal experiments were performed under protocols approved by University of Pittsburgh Animal Care and Use Committee. All mice were housed in specific-pathogen-free conditions at an ambient temperature of 20–26°C and humidity of 30–70% with a 12 h:12 h light:dark cycle before use.
Wang W., Wu S., Cen Z., Zhang Y., Chen Y., Huang Y., Cillo A.R., Prokopec J.S., Quarato G., Vignali D.A., Stewart-Ornstein J., Li S., Lu B, & Gong Y.N. (2022). Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy. Cell reports, 41(5), 111582.
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Murine Models for Immunology Research

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All the experiments were performed using C57BL/6 (B6) mice. B6 mice were obtained from the National Cancer Institute and used at 6 – 12 wk of age. Rag1−/− mice were purchased from Taconic Farms (Derwood, MD). IL-10−/− and IL-10RB−/− mice were purchased from The Jackson Laboratory (Sacramento, CA). All mice were maintained at an American Association for the Accreditation of Laboratory Animal Care–accredited animal facility at the National Institute of Allergy and Infectious Diseases and housed in accordance with the procedures outlined in the Guide for the Care and Use of Laboratory Animals under an animal study proposal approved by the National Institute of Allergy and Infectious Diseases Animal Care and Use Committee.
Filardy A.A., He J., Bennink J., Yewdell J, & Kelsall B.L. (2015). Post-transcriptional control of NLRP3 inflammasome activation in colonic macrophages. Mucosal immunology, 9(4), 850-858.
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4

Modulating Immune Responses in Malaria and LCMV Models

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C57BL/6 wild type, tcrα-/-, Blimp-1-eYFP reporter, ifnar1-/-, and il10rb-/- mice (6–8 weeks, 16–21 g) were purchased from Jackson Laboratories. Plasmodium yoelii (clone 17XNL, obtained from MR4 (ATCC)) was routinely passaged through mosquitoes and mouse infections were initiated by serial transfer of 106 parasite-infected red blood cells via tail vein injection. LCMV clone 13 infection was administered intravenously at a dose of 106 PFU. Parasitemia was measured using flow cytometry as described [75 (link)]. One day prior to P. yoelii infection, mice were injected i.p. with either 1.5 mg of MOPC isotype control or MAR1-5A3 (α-IFNAR) monoclonal antibodies, followed by 0.75 mg doses on days 2 and 4 p.i. Anti-IL-10 receptor (clone 1B1.3a), anti-IFN-γ (clone XMG1.2) were injected i.p. in 200 and 500 μg doses on days 7 and 10 p.i., respectively. All biologics were acquired from BioXcell.
Zander R.A., Guthmiller J.J., Graham A.C., Pope R.L., Burke B.E., Carr D.J, & Butler N.S. (2016). Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria. PLoS Pathogens, 12(10), e1005945.
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5

Murine Models for Immunology Research

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All the experiments were performed using C57BL/6 (B6) mice. B6 mice were obtained from the National Cancer Institute and used at 6 – 12 wk of age. Rag1−/− mice were purchased from Taconic Farms (Derwood, MD). IL-10−/− and IL-10RB−/− mice were purchased from The Jackson Laboratory (Sacramento, CA). All mice were maintained at an American Association for the Accreditation of Laboratory Animal Care–accredited animal facility at the National Institute of Allergy and Infectious Diseases and housed in accordance with the procedures outlined in the Guide for the Care and Use of Laboratory Animals under an animal study proposal approved by the National Institute of Allergy and Infectious Diseases Animal Care and Use Committee.
Filardy A.A., He J., Bennink J., Yewdell J, & Kelsall B.L. (2015). Post-transcriptional control of NLRP3 inflammasome activation in colonic macrophages. Mucosal immunology, 9(4), 850-858.
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