Three hundred and forty individuals including 125 control subjects, 103 SCD and 112 MCI patients completed [18F]flutemetamol PET scans. [18F]flutemetamol was manufactured at the radiopharmaceutical production site in Risø, Denmark, using a FASTlab synthesizer module (GE Healthcare, Cleveland, OH). Subjects received a single dose of [18F]flutemetamol according to a method described previously25 (link). PET/CT scanning of the brain was conducted at two sites using the same type of scanner (Gemini, Philips Healthcare, Best, the Netherlands). Summed PET images from 90–110 min post injection representing the average uptake of [18F]flutemetamol over this time were analyzed using NeuroMarQ software (provided by GE Healthcare, Cleveland, OH). A volume of interest (VOI) template was applied for the following 9 bilateral regions: prefrontal, parietal, lateral temporal, medial temporal, sensorimotor, occipital, anterior cingulate, posterior cingulate/precuneus and a global neocortical composite region26 (link). The standardized uptake value ratio (SUVR) was defined as the uptake in a VOI normalized for the mean cerebellar cortex uptake.
Fastlab synthesizer module
Manufactured by GE Healthcare
Sourced in Denmark
The FASTlab synthesizer module is a compact and automated instrument designed for the synthesis of radiopharmaceuticals used in Positron Emission Tomography (PET) imaging. The module provides a controlled environment for the preparation of these radioactive compounds, ensuring consistent and reliable results.
Automatically generated - may contain errors
Lab products found in correlation
2 protocols using fastlab synthesizer module
1
PET Imaging of Amyloid Deposition in SCD, MCI
2
Visualization of Cerebral Amyloid-beta Using 18F-Flutemetamol PET
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
18F-flutemetomol PET scans for visualization of cerebral Aβ depositions were completed for 382 individuals, including 244 CU subjects and 138 MCI patients. Production of 18F-flutemetamol was performed at the radiopharmaceutical production site in Risø, Denmark, using a FASTlab synthesizer module (GE Healthcare, Cleveland, OH). PET/CT scans of the brain were obtained from 2 different sites using the same type of scanner (Germini; Philips Healthcare, Best, Netherlands). 18F-flutemetamol summation images for the period 90–110 minutes post injection a single dose of 18F-flutemetamol was analyzed using the NeuroMarQ software (GE Healthcare). A volume of interest (VOI) template was applied to define a global neocortical composite region, encompassing prefrontal, parietal, temporal lateral, anterior cingulate, posterior cingulate, and precuneus VOIs (Lundqvist et al., 2013 (link)). The standardized uptake value ratio was defined as the uptake in a VOI normalized to a composite reference region (whole cerebellum, the pons/brainstem, and eroded cortical white matter).
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!