Desipramine

Manufactured by Bio-Techne

Sourced in Spain

Desipramine is a laboratory reagent used for experimental purposes. It is a tricyclic antidepressant compound that functions as a reuptake inhibitor of the neurotransmitters norepinephrine and serotonin. Desipramine is commonly utilized in scientific research settings to study the effects of norepinephrine and serotonin modulation on various biological processes.

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Lab products found in correlation

Close spelling variants of this product

Desipramine hydrochloride

2 protocols using desipramine

Evaluation of Antidepressant Compounds

Cited 1 time

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Fluoxetine (#H6995, Bosche Scientific), citalopram (#C505000, Toronto Research Chemicals), paroxetine (#2141, Tocris), fluvoxamine (#1033), venlafaxine (#2917, Tocris), reboxetine (#1982, Tocris), imipramine (#I7379-5G, Sigma–Aldrich), clomipramine (#C7291, Sigma–Aldrich), desipramine (#3067, Tocris), phenelzine (#P6777, Sigma–Aldrich), rolipram (#R6520, Sigma–Aldrich), ketamine (#3131, Tocris), 2R, 6R-Hydroxynorketamine and 2S, 6S-Hydroxynorketamine (#6094 and #6095, respectively, Tocris), carbamazepine (#4098, Tocris), chlorpromazine (#C8138, Sigma–Aldrich), flupenthixol (#4057, Tocris), and pimozide (#0937, Tocris) were investigated in this study. The compounds were dissolved in dimethyl sulfoxide (DMSO) that was also used as a vehicle in all the experiments. Concentrations tested (Table 1) were selected based on earlier in vitro studies from our research group (Fred et al., 2019 (link); Casarotto et al., 2021 (link)) and other laboratories (Johansen et al., 2015 (link)).

Fred S.M., Kuivanen S., Ugurlu H., Casarotto P.C., Levanov L., Saksela K., Vapalahti O, & Castrén E. (2022). Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro. Frontiers in Pharmacology, 12, 755600.

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Microdialysis Procedure for Neurotransmitter Assay

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All reagents used were of analytical grade and were obtained from Merck (Germany). 5-HT oxalate, NE bitartrate, (±)-8-hydroxi-2(dipropylamino)tetralin hydrobromide (8-OH-DPAT), and clonidine were from Sigma-Aldrich-RBI (Madrid, Spain). Fluoxetine, reboxetine, citalopram hydrobromide and desipramine were from Tocris (Madrid, Spain). To assess the local effects in microdialysis procedures, drugs were dissolved in artificial cerebrospinal fluid (aCSF) and were administered by reverse dialysis at the stated concentrations [9, 10]. All other drugs dissolved in saline or aCSF as required. Concentrated solutions (1mM; pH adjusted to 6.5-7 with NaHCO3 when necessary) were stored at -80ºC and working solutions were prepared daily by dilution in aCSF.

Fullana M.N., Ferrés-Coy A., Ortega J.E., Ruiz-Bronchal E., Paz V., Meana J.J., Artigas F, & Bortolozzi A. (2019). Selective Knockdown of TASK3 Potassium Channel in Monoamine Neurons: a New Therapeutic Approach for Depression. Molecular neurobiology, 56(4).

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