Anti mdm2

Manufactured by GenScript

Anti-Mdm2 is a lab equipment product designed to detect and quantify the Mdm2 protein. Mdm2 is a key regulator of the p53 tumor suppressor protein. This product provides a tool for researchers to study the interactions and functions of Mdm2 in various biological systems.

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Lab products found in correlation

3 protocols using anti mdm2

Investigating Cellular Stress Responses

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Dimethyl sulfoxide (DMSO) and MG132 were from Fisher Scientific. DMSO was used as a vehicle in this study. Kainic acid was from Alomone Labs. Saline was from Hanna Pharmaceutical Supply Co., Inc. Pifithrin and Thapsigargin were from AdipoGen. Cycloheximide was from Sigma. The antibodies used in this study were purchased from Santa Cruz Biotechnology (anti-Mdm2), GenScript Corporation (anti-Gapdh), and Cell Signaling (anti-p-Mdm2, anti-p53 and anti-ubiquitin). HRP-conjugated secondary antibodies were from Jackson Immunoresearch and Cell Signaling.

Liu D.C., Lee K.Y., Lizarazo S., Cook J.K, & Tsai N.P. (2021). ER stress-induced modulation of neural activity and seizure susceptibility is impaired in a fragile X syndrome mouse model. Neurobiology of disease, 158, 105450.

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Comprehensive Protein Regulation Analysis

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Cycloheximide was from Santa Cruz Biotechnology. Actinomycin-D was from Sigma. MG132 was from Selleck Chemical. Puromycin was from MP Biomedicals. Kainic acid and Thapsigargin were from Alomone Lab. Pifithrin-α was from Adipogen Corporation. Salubrinal was from Enzo Life Sciences. Dimethyl sulfoxide (DMSO) was from Fisher Scientific. DMSO was used as a vehicle in this study. The antibodies used in this study were purchased from Santa Cruz Biotechnology (anti-Mdm2, anti-Lamin A/C, anti-HSP-90), GenScript Corporation (anti-Gapdh), Millipore (anti-Puromycin), and Cell Signaling (anti-ubiquitin, anti-p-Mdm2, anti-p53, anti-BiP, anti-PDI, anti-PERK, anti-ATF6, anti-XBP1s, anti-eIF2α and anti-p-eIF2α). HRP-conjugated secondary antibodies were from Santa Cruz Biotechnology and Cell Signaling. The lentiviral control non-target shRNA and p53 shRNA were from Santa Cruz Biotechnology.

Liu D.C., Eagleman D.E, & Tsai N.P. (2019). Novel roles of ER stress in repressing neural activity and seizures through Mdm2- and p53-dependent protein translation. PLoS Genetics, 15(9), e1008364.

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Investigating Akt and Erk1/2 Signaling

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DHPG was from Abcam. Dimethyl sulfoxide (DMSO) and MG132 were from Fisher Scientific. MK-2206 was from AdooQ Bioscience. DMSO was used as the vehicle throughout this study. The antibodies used in this study were purchased from Santa Cruz Biotechnology (anti-Mdm2), GenScript Corporation (anti-Gapdh), and Cell Signaling (anti-Akt, anti-p-Akt, anti-Erk1/2, anti-p-Erk1/2, anti-p53, and anti-ubiquitin). Horseradish peroxidase (HRP)-conjugated secondary antibodies were from Santa Cruz Biotechnology, Cell Signaling, and Jackson ImmunoResearch.

Liu D.C., Soriano S., Yook Y., Lizarazo S., Eagleman D.E, & Tsai N.P. (2020). Chronic Activation of Gp1 mGluRs Leads to Distinct Refinement of Neural Network Activity through Non-Canonical p53 and Akt Signaling. eNeuro, 7(2), ENEURO.0438-19.2020.

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