Javascript

A Web application user interface (UI) was developed for INT²GRATE|HPPGL to facilitate the ease of use of the Variant Evidence Framework (Figure 1). The UI shows the INT²GRATE|HPPGL parameters as a one-page questionnaire with user single-response radio button inputs. Text fields were created for variant information input (i.e., HGVS, cDNA, and protein). User responses are programmatically assessed using a Javascript (Oracle Corporation, Austin, TX, USA) algorithm that functions in the user’s browser to align the user’s responses with the corresponding Variant Evidence Framework categories and responses in the backend of the website. User data are processed on the client side in the user’s browser and are not stored on the host server. Upon completion of the answers (i.e., the input of the HPPGL’s related parameters) in the questionnaire and after submitting the form, the user can see the corresponding INT²GRATE|HPPGL comment. The UI provides an option for the user to download and store a spreadsheet documenting their responses and associated INT²GRATE|HPPGL comments. Additionally, the UI features an API for data sharing and automatic submission of variants and associated INT²GRATE|HPPGL parameters to ClinVar (as discussed in Section 2.1.4. Variant Data Sharing via API below).