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β aescin

Manufactured by Merck Group
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Sourced in Germany, Canada

β-aescin is a purified compound derived from the Aesculus hippocastanum (horse chestnut) tree. It is a saponin glycoside that has demonstrated membrane-stabilizing and anti-inflammatory properties in various scientific studies.

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Lab products found in correlation

Naproxen, by Merck Group (1 mentions) Chloroform, by Thermo Fisher Scientific (1 mentions) Arium pro vf system, by Sartorius (1 mentions) Ketoconazole, by Glentham Life Sciences (1 mentions) Posaconazole, by Glentham Life Sciences (1 mentions) Amphotericin b, by Glentham Life Sciences (1 mentions)

3 protocols using β aescin

1

Preparation of Phospholipid Vesicles with Naproxen and Saponin

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For vesicle preparation, the phospholipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC, >99 %, CAS: 18194-24-6, Lipoid GmbH, Ludwigshafen, Germany), the NSAID naproxen (CAS: 22204-53-1, Sigma-Aldrich, Munich, Germany) and the saponin β -aescin (≥95 %, CAS: 6805-41-0, Sigma-Aldrich) were used without further purification. Chloroform (≥ 99.8 %, CAS: 67-66-3) was purchased from Fisher Chemicals, Waltham, MA, USA. Purified water (arium pro VF System, Sartorius AG, Germany) was used for the aqueous sodium phosphate buffer (50 mM, pH 7.4).
Hägerbäumer P., Gräbitz-Bräuer F., Annegarn M., Dargel C., Stank T.J., Bizien T, & Hellweg T. (2023). Interactions between DMPC Model Membranes, the Drug Naproxen, and the Saponin β-Aescin. Pharmaceutics, 15(2), 379.
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2

Hepatoprotective Effects of Silymarin and β-Aescin

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Silymarin was purchased from Tejkamal Pharmaceutical Pvt Ltd, Mumbai, India (Batch no. SIST-010). β-Aescin (E1378, >95%, powder) was purchased from Sigma Aldrich (St. Louis, MO), invoice number A/5012, Batch no. SLBC6907V. Biochemical enzymatic kits such as AST and ALT were purchased from Transasia Bio-Medicals Ltd, Solan, Himachal Pradesh, India. ALP kit was purchased from Span Diagnostics Ltd, Surat, India. Bilirubin kit was purchased from Spinreact, Girona, Spain. TGF-β1 and TNF-α ELISA kit were purchased from R&D Systems, Bio-Techne, Minneapolis, MN. All chemicals and biochemical reagents were of analytical grade and were used as freshly prepared solutions.
Singh H., Sidhu S., Chopra K, & Khan M.U. (2017). The novel role of β-aescin in attenuating CCl4-induced hepatotoxicity in rats. Pharmaceutical Biology, 55(1), 749-757.
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3

Synthesis and Characterization of Novel Antifungal Compounds

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List of compounds used in our research:
Newly synthesized AABs (TMDAB):

C9H19 molar mass: 328.49 (g/mol);

C11H23 molar mass: 356.54 (g/mol);

C13H27 molar mass: 384.60 (g/mol);

C15H31 molar mass: 412.65 (g/mol).

Patent no.: PL 237430 B1
Antifungal compounds:

β-aescin (C55H86O24), CAS no.: 11072-93-8 (Sigma-Aldrich, Oakville, ON, Canada);

Fluconazole (C10H8N6), CAS no.: 514222-44-7 (Glentham Life Sciences, Corsham, UK);

Itraconazole (C35H38Cl2N8O4), CAS no.: 84625-61-6 (Glentham Life Sciences, Corsham, UK);

Ketoconazole (C26H28Cl2N4O4), CAS no.: 65277-42-1 (Glentham Life Sciences, Corsham, UK);

Voriconazole (C16H14F3N5O), CAS no.: 137234-62-9 (Glentham Life Sciences, Corsham, UK);

Posaconazole (C37H42F2N8O4), CAS no.: 171228-49-2 (Glentham Life Sciences, Corsham, UK);

Caspofungin (C52H88N10O15), CAS no.: 179463-17-3 (Glentham Life Sciences, Corsham, UK);

5-Fluorocytosine (C4H4FN3O), CAS no.: 2022-85-7 (Glentham Life Sciences, Corsham, UK);

Amphotericin B (C47H73NO17), CAS no.: 1397-89-3 (Glentham Life Sciences, Corsham, UK).

Paluch E., Bortkiewicz O., Widelski J., Duda-Madej A., Gleńsk M., Nawrot U., Lamch Ł., Długowska D., Sobieszczańska B, & Wilk K.A. (2024). A Combination of β-Aescin and Newly Synthesized Alkylamidobetaines as Modern Components Eradicating the Biofilms of Multidrug-Resistant Clinical Strains of Candida glabrata. International Journal of Molecular Sciences, 25(5), 2541.
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