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Zaleplon

Manufactured by Merck Group
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Sourced in Egypt

Zaleplon is a pharmaceutical product developed by Merck Group for use in the medical and scientific research fields. It functions as a hypnotic agent, primarily designed to assist with sleep-related disorders and conditions. The core purpose of Zaleplon is to provide a controlled and measured sleep-inducing effect for patients or research subjects, as required by healthcare professionals or researchers. No further details or interpretation on the intended use of this product can be provided in an unbiased and factual manner.

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Lab products found in correlation

Labrafil, by Merck Group (1 mentions) Transcutol, by Merck Group (1 mentions) Potassium phosphate, by Merck Group (1 mentions) Hydralazine hydrochloride, by Merck Group (1 mentions) O6 benzylguanine, by Merck Group (1 mentions) Zoniporide dihydrochloride, by Bio-Techne (1 mentions) Sgx523, by Bio-Techne (1 mentions) Mgcl2, by Merck Group (1 mentions) Formic acid, by Merck Group (1 mentions) Nadph, by Merck Group (1 mentions) Phenacetin, by Merck Group (1 mentions) Allopurinol, by Merck Group (1 mentions) Zoniporidehydrochloride hydrate, by Merck Group (1 mentions)

3 protocols using zaleplon

1

Zaleplon Formulation Development

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Zaleplon was kindly donated as a gift from Al-Andals Pharmaceuticals Company (Egypt), labrafil & (Propyelene glycol mono caprylate) capryol, Labrosol and transcutol were obtained from Sigma Aldrich (St. Louis, USA). Ethanol was purchased from ADWIC, (Egypt). All other materials were of analytical grade.
Khalifa M.K., Salem H.A., Shawky S.M., Eassa H.A, & Elaidy A.M. (2019). Enhancement of zaleplon oral bioavailability using optimized self-nano emulsifying drug delivery systems and its effect on sleep quality among a sample of psychiatric patients. Drug Delivery, 26(1), 1243-1253.
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2

Hepatic S9 Fraction Procurement and Characterization

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Potassium phosphate, formic acid, NADPH, MgCl2, zaleplon, O6-benzylguanine, and hydralazine hydrochloride were purchased from Sigma-Aldrich (St. Louis, MO). Zoniporide dihydrochloride, BIBX1382 dihydrochloride, and SGX523 were purchased from Tocris Bioscience (R&D Systems, Minneapolis, MN). Pooled human hepatic S9 (150-donor, mixed gender pool) was obtained from BD Biosciences (San Diego, CA), and male Sprague-Dawley rat (n=36 pool), cynomolgus monkey (n=2, pool), and CD-1 mouse (n=170 pool) hepatic S9 were obtained from Corning Inc. (Tewksbury, MA). Male rhesus monkey (n= 6 pool) and Hartley guinea pig (n=50 pool) hepatic S9 were purchased from XenoTech (Lenexa, KS), and male Gottingen minipig (n= 7 pool) hepatic S9 was purchased from BioreclamationIVT (Baltimore, MD). All solvents used for bioanalysis were purchased from Sigma-Aldrich or Fisher Scientific (Waltham, MA) and were of high-performance liquid chromatography (HPLC) grade.
Crouch R.D., Hutzler J.M, & Daniels J.S. (2017). A novel in vitro allometric scaling methodology for aldehyde oxidase substrates to enable selection of appropriate species for traditional allometry. Xenobiotica; the fate of foreign compounds in biological systems, 48(3), 219-231.
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3

Optimized Expression of Human Aldehyde Oxidase in E. coli

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The
lactose-inducible TP1017 E. coli strain
(as JM101/Δ mobAB::Kan; unpublished) was a
gift from Tracey Palmer of the University
of Dundee. E. coli codon-optimized
human AO-containing plasmid pTHco-hAOX1 was the expression vector.33 (link) All E. coli expression
media components were obtained from Sigma. Human liver cytosol (HLC),
pooled from 50 individual donors (male and female), was purchased
from XenoTech (Batch H06610.C Lot no. 141002, Lenexa, KS). DACA was
synthesized using a method described previously13 (link) with some revisions (described in Supporting Information). DACA-acridone hydrochloride was a gift from William
Denny, University of Auckland. O6BG was purchased from
Toronto Research Chemicals, Inc. (Toronto, Canada). Raloxifene hydrochloride
was obtained from Enzo Life Sciences (Farmingdale, NY). Zoniporide
hydrochloride hydrate, zaleplon, allopurinol, hydralazine, acetic
anhydride, and internal standards 2-methyl-4(3H)-quinazolinone
and phenacetin were purchased from Sigma-Aldrich (St. Louis, MO).
3-Aminoquinoline and 4-methylvaleric acid chloride were purchased
from TCI America (Portland, OR).
Paragas E.M., Humphreys S.C., Min J., Joswig-Jones C.A., Leimkühler S, & Jones J.P. (2017). ecoAO: A Simple System for the Study of Human Aldehyde Oxidases Role in Drug Metabolism. ACS Omega, 2(8), 4820-4827.
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