Microcrystalline cellulose (MCC, Vivapur® 102, JRS Pharma, Rosenberg, Germany) and anhydrous dicalcium phosphate (DCPA, Emcompress® Anhydrous, JRS Pharma, Rosenberg, Germany) were used as model materials. Magnesium stearate (MgSt, Magnesia GmbH, Lüneburg, Germany) was used as a lubricant. The characteristic particle sizes of MCC and DCPA are in a comparable range with slightly lower particle sizes for MCC (Table 1 ). The solid, bulk and tapped density of DCPA is higher, almost double, than MCC.
Emcompress anhydrous
Manufactured by JRS Pharma
Sourced in Germany
Emcompress® Anhydrous is a direct compression excipient used in the formulation of solid oral dosage forms. It is a calcium phosphate-based diluent that provides bulk to the final product.
Automatically generated - may contain errors
Lab products found in correlation
Vivapur 102, by JRS Pharma (2 mentions)
Emcompress, by JRS Pharma (1 mentions)
Avicel ph102, by FMC Biopolymer (1 mentions)
Lh 21, by Shin-Etsu Chemical (1 mentions)
Magnesium chloride, by Merck Group (1 mentions)
Sodium chloride (nacl), by Merck Group (1 mentions)
Magnesium stearate, by Mallinckrodt (1 mentions)
Pearlitol 200sd, by Roquette (1 mentions)
Kollidon cl, by BASF (1 mentions)
4 protocols using emcompress anhydrous
1
MCC and DCPA Particle Characterization
2
Deformation Behavior of Tableting Excipients
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Microcrystalline cellulose (MCC; Vivapur® 102, JRS Pharma, Rosenberg, Germany), anhydrous dicalcium phosphate (DCP; Emcompress® anhydrous, JRS Pharma, Rosenberg, Germany), lactose (Tablettose® 70, Meggle, Wasserburg am Inn, Germany), partially pregelatinised starch (starch; Superstarch® 200, DFE Pharma, Goch, Germany), and magnesium stearate (MgSt; Magnesia, Lüneburg, Germany) were used as tableting excipients. Based on the interpretation of compression data, e.g., applying the model of Heckel [27 ], literature describes the deformation behavior of MCC, DCP, lactose, and starch as plastic/ductile, brittle/fractioning, intermediate (partially ductile and brittle), and visco-plastic (e.g., [28 (link)]), respectively.
3
Formulation and Characterization of Oral Solid Dosage Forms
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Microcrystalline cellulose (MCC; Avicel PH102, FMC Biopolymer, Philadelphia, PA), lactose monohydrate (LM; #316 Fastflo® NF, Foremost Farms, Clayton, WI), mannitol (Mann; Pearlitol® 200SD, Roquette America Inc., Keokuk, IA), dicalcium phosphate anhydrate (DCPA; Anhydrous Emcompress®, JRS Pharma, Patterson, NY), dicalcium phosphate dihydrate (DCPD; Emcompress®, JRS Pharma, Patterson, NY), ibuprofen (IBN; Sigma Aldrich, St. Louis, MO), celecoxib (CEL; Aarti Drugs Pvt Ltd., Mumbai, India), hydroxypropyl cellulose (HPC; Klucel EF-PHARM, Ashland, Wilmington DE), and magnesium stearate (MgSt; non-bovine, HyQual™, Mallinckrodt, St. Louis, MO) were used as received.
4
Tablet Formulation Development and Characterization
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Tablet excipients included microcrystalline cellulose (MCC) (Avicel®PH-102, FMC International), mannitol (Pearlitol®200 SD, Roquette), lactose (FastFlo®316, Foremost Farms USA) and dibasic calcium phosphate anhydrous (DCPA) (Anhydrous Emcompress, JRS Pharma) as fillers. The disintegrants croscarmellose sodium (CCS) (FMC International), crospovidone (XPVP) (Kollidon®CL, BASF), low-substituted hydroxypropyl cellulose (L-HPC) (LH-21, Shin-Etsu Chemical Co.) and sodium starch glycolate (SSG) (Primojel®, DFE Pharma) were used in the tablet formulations. Magnesium stearate (Mallinckrodt) was used as a lubricant. Magnesium chloride and sodium chloride (Sigma Aldrich) were used to make saturated salt solutions.
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