Cefotaxime sodium

Manufactured by Thermo Fisher Scientific

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Cefotaxime sodium is a cephalosporin antibiotic used in the treatment of various bacterial infections. It functions as an inhibitor of cell wall synthesis in susceptible bacteria.

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Cefotaxime (170 citations)

2 protocols using cefotaxime sodium

Antibiotic Susceptibility of Bovine Pathogens

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All Salmonellae (23 isolates) and E.
coli (96 isolates) recovered from diarrheic calves were tested for their antimicrobial susceptibility to 12 different antimicrobial discs including enrofloxacin (10 µg), marbofloxacin (10 µg), gentamycin (10 µg), erythromycin (15 µg), cefotaxime sodium (30 µg), amoxicillin (10 µg), penicillin (10 µg), tetracycline (30 µg), streptomycin (10 µg), trimethoprim-sulphamethoxazol (1.25 + 23.75 µg), spectinomycin (20 µg) and neomycin (20 µg) (Oxoid, Basing Stoke, UK). Antimicrobial susceptibility testing was performed using disc diffusion method on Muller Hinton agar according to Clinical and Laboratory Standards Institute (CLSI) (2012) . The antibiotic susceptibility was based on the induced inhibition zones according to the guidelines of the CLSI (2012) .

El-Seedy F.R., Abed A.H., Yanni H.A, & Abd El-Rahman S.A. (2016). Prevalence of Salmonella and E. coli in neonatal diarrheic calves. Beni-Suef University Journal of Basic and Applied Sciences, 5(1), 45-51.

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Antimicrobial Susceptibility of Bacterial Isolates

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Two hundred representative bacterial isolates were tested due to limited resources. Fifty isolates from each of S. aureus, NAS, Streptococcus spp. and E. coli were selected and examined for their antimicrobial sensitivity (AMS) to 13 different antimicrobial compounds by disc diffusion test. The tested isolates (n = 50) were selected randomly but representatively from single and different mixed infections. The following antimicrobial discs ( Oxoid, Ltd., Basingstoke, UK) were used: ampicillin (10 µg), amoxicillin-clavulanic acid (30 µg), cefoxitin (30 µg), cefotaxime sodium (30 µg), vancomycin (30 µg), levofloxacin (5 µg), ciprofloxacin (5 µg), doxycycline HCl (30 µg), clindamycin (2 µg), gentamicin (10 µg), florfenicol (30 µg) and sulfamethoxazole-trimethoprim (25 µg) and colistin sulfate (10 µg). The phenotypic antimicrobial susceptibility tests were conducted using the disc diffusion method on Muller Hinton agar (Oxoid, Ltd., Basingstoke, UK), and the result was interpreted according to CLSI [24 ]. The AMS was based on the induced inhibition zones according to breakpoints available in the CLSI [24 ]. Resistance to three/or more antimicrobials from different antibiotic categories was considered as MDR, according to Chandran et al. [25 (link)].

Abed A.H., Menshawy A.M., Zeinhom M.M., Hossain D., Khalifa E., Wareth G, & Awad M.F. (2021). Subclinical Mastitis in Selected Bovine Dairy Herds in North Upper Egypt: Assessment of Prevalence, Causative Bacterial Pathogens, Antimicrobial Resistance and Virulence-Associated Genes. Microorganisms, 9(6), 1175.

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