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Sp600125

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SP600125 is a laboratory reagent that functions as a reversible, ATP-competitive inhibitor of the c-Jun N-terminal kinase (JNK) signaling pathway. It is commonly used in research studies to investigate the role of JNK in various cellular processes and disease models.

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Lab products found in correlation

Daunorubicin, by Meilun (2 mentions) Doxorubicin, by Meilun (2 mentions) Sorafenib, by Meilun (2 mentions) Z vad fmk, by Meilun (1 mentions)

2 protocols using sp600125

1

Antibody and Chemical Reagents for Cell Signaling

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The antibodies including Anti-GAPDH, Anti-CASK, Caspase-7, Anti-LC3B, SQSTM1/p62, Beclin-1, Anti-JNK1+JNK2+JNK3, Anti-phospho-JNK, Anti-c-Jun, Anti-phospho-c-Jun, Anti-MRP3, Anti-ABCG2 were listed in Table S2. JNK inhibitor SP600125 (MB5595), 3-Methyladen (3-MA, MB5063), Z-VAD-FMK (MB3313), sorafenib (MB1666), doxorubicin (MB1087), daunorubicin (MB1074), decitabine (5-Aza, MB1075), G418 (MB1733), puromycin (MB2005) were purchased from Dalian Meilun Biotechnology.
Ding B., Bao C., Jin L., Xu L., Fan W, & Lou W. (2021). CASK Silence Overcomes Sorafenib Resistance of Hepatocellular Carcinoma Through Activating Apoptosis and Autophagic Cell Death. Frontiers in Oncology, 11, 681683.
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2

Investigating Cell Signaling Pathways

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The antibodies including Anti-GAPDH, Anti-CASK, Anti-PARP, Anti-Cleaved PARP, Caspase-7, Anti-LC3B, SQSTM1/p62, Beclin-1, Anti-JNK1 + JNK2 + JNK3, Anti-phospho-JNK, Anti-c-Jun, Anti-phospho-c-Jun, Anti-MRP3, Anti-ABCG2 were listed in Table S2. JNK inhibitor SP600125 (MB5595), 3-Methyladen (3-MA, MB5063), Z-VAD-FMK (MB3313), sorafenib (MB1666), doxorubicin (MB1087), daunorubicin (MB1074), decitabine (5-Aza, MB1075), G418 (MB1733), puromycin (MB2005) were purchased from Dalian Meilun Biotechnology.
Ding B., Bao C., Jin L., Xu L., Dai Z., Fan W., & Lou W. (2021). CASK Silence Enhances Chemosensitivity of Hepatocellular Carcinoma Through activating Apoptosis, Inducing JNK/c-Jun-Mediated Autophagic Cell Death and Decreasing ABCG2.
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