Blood lipids were measured by LabCorp (Burlington, NC). Commercially available multiarray kits were used to quantify plasma levels of interleukin 1β (IL-1β), IL-6, IL-8, tumor necrosis factor alpha (TNFα), C-reactive protein (CRP), soluable vascular cell adhesion molecule 1 (sVCAM1), soluable intercellular adhesion molecule 1 (sICAM1), serum amyloid A (SAA), tissue-type plasminogen activator (tPA), plasminogen, D-dimer, and von Willebrand factor (vWF) (Meso-Scale Diagnostics, Gaithersburg, MD). In addition, vasoconstrictor endothelin-1 (ET-1) and oxidized low-density lipoprotein (Ox-LDL) were measured using kits purchased from Bachem (Torrence, CA) and Mercodia (Winston Salem, NC), respectively. All assays were carried out according to the manufacturer’s instructions.
D dimer
Manufactured by Mesoscale
Sourced in United States
The D-dimer is a laboratory test used to detect the presence of fibrin degradation products in the blood. It is a biomarker that can indicate the presence of blood clots or the breakdown of existing blood clots.
Automatically generated - may contain errors
Lab products found in correlation
4 protocols using d dimer
1
Comprehensive Cardiometabolic Biomarker Profiling
2
Blood Lipid and Biomarker Analysis
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A portion of whole blood samples was sent for lipid analysis (LabCorp, Burlington, NC). The other portion of blood samples was separated for plasma and stored at -80 ℃ prior to biomarker analysis. Commercially available multi-array plates were used to quantify levels of von Willebrand factor (vWF), tissue plasminogen activator (tPA), and D-dimer (MesoScale, Rockville, MD). Endothelin-1 was tested using an ELISA kit purchased from Peninsula Laboratories International (San Carlos, CA). All experiments were performed per manufacturers’ instructions.
3
Quantification of Inflammatory Markers
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Commercially available ELISA kits were used to quantify plasma levels of interleukin 1β (IL-1β), IL-6, IL-8, tumor necrosis factor alpha (TNFα), CRP, soluble vascular cell adhesion molecule 1 (sVCAM1), soluble intercellular adhesion molecule 1 (sICAM1), serum amyloid A (SAA), E-selectin, D-dimer, and von Willebrand factor (vWF) (MesoScale Diagnostics, Gaithersburg, MD, USA). All assays were carried out according to manufacturer’s instructions.
4
Quantifying Cardiovascular Biomarkers
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A portion of each blood sample was sent to a commercial lab (LabCorp, Burlington, NC) for quantification of blood lipids. The remainders of the blood samples were separated for plasma and stored at -80 ℃ prior to biomarker analysis. Commercially available multi-array plates were used to quantify levels of von Willebrand factor (vWF), tissue plasminogen activator (tPA), and D-dimer (MesoScale, Rockville, MD). In addition, vascular inflammation biomarkers including soluable intercellular adhesion molecule 1 (sICAM-1), soluable vascular cell adhesion molecule 1 (sVCAM-1), and serum amyloid A (SAA) were measured using a multiplex kit from MesoScale Diagnostics (Gaithersburg, MD). All experiments were performed per manufacturers’ instructions.
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