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Phenotyper system

Manufactured by Noldus
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Sourced in Netherlands, United States

The PhenoTyper® system is a laboratory equipment designed for automated behavioral monitoring of small laboratory animals in a controlled environment. The system consists of an observation chamber and associated hardware and software components to track and record animal movements and behaviors over extended periods of time.

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Lab products found in correlation

Phenotyper arena, by Noldus (1 mentions) Ethovision software, by Noldus (1 mentions) Ethovision xt software, by Noldus (1 mentions)

3 protocols using phenotyper system

1

Automated Monitoring of Murine Locomotion

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Daily home cage activity patterns were tracked and recorded using the PhenoTyper® system (Noldus, Wageningen, Netherlands). Mice were placed into the PhenoTyper arena (30 × 30 cm) and continuously monitored for 24 h. The EthoVision software (Noldus, Wageningen, Netherlands) was used to determine and quantify relevant behavioral parameters, including total mobility, distance covered and velocity.
Berger S., Stattmann M., Cicvaric A., Monje F.J., Coiro P., Hotka M., Ricken G., Hainfellner J., Greber-Platzer S., Yasuda M., Desnick R.J, & Pollak D.D. (2020). Severe hydroxymethylbilane synthase deficiency causes depression-like behavior and mitochondrial dysfunction in a mouse model of homozygous dominant acute intermittent porphyria. Acta Neuropathologica Communications, 8, 38.
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2

Heroin Withdrawal Behaviors in Mice

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Mice received subcutaneous heroin twice daily starting at a dose of 10 mg/kg and the dose was increased by 5 mg/kg each time until reaching 50 mg/kg by the fifth day [17 ]. On day 5, mice received 50 mg/kg heroin treatment at 8:00 AM. After 2 h, the mice received saline, clonidine or lorcaserin. Naloxone was administered 30 min later to precipitate jumping and other withdrawal symptoms [17 ].
Behavioral assessment was conducted with a Noldus PhenoTyper system. Mice were individually placed into clear square observation chambers (30 cm by 30 cm by 35 cm tall) with bedding at the bottom. The heroin withdrawal behaviors included jumping (all feet off the floor), burrowing (escape digging), body grooming, rearing, wet dog shakes (whole body shakes), head shakes, digging body, paw licking, penile grooming, and extended posture. Each behavior was counted for 30 min immediately after the naloxone challenge. The distance traveled and immobility in heroin-withdrawn mice treated with saline, lorcaserin or clonidine were also recorded for 60 min beginning immediately after naloxone injection.
Wu X., Pang G., Zhang Y.M., Li G., Xu S., Dong L., Stackman RW J.r, & Zhang G. (2015). Activation of serotonin 5-HT2C receptor suppresses behavioral sensitization and naloxone-precipitated withdrawal symptoms in heroin-treated mice. Neuroscience letters, 607, 23-28.
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3

Open-field Locomotor Activity Assay

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To evaluate the locomotor activity, an open-field test was performed. In the afternoon, the animals were removed from the bioterium and taken to the test room, where the apparatus used in the experiment was located (the animals were not deprived from food or water). The habituation period was 30 min. After habituation, animals were placed in the apparatus (PhenoTyper®System; Noldus, Information Technology, Leesburg, VA, United States) and remained in the test for 30 min. The apparatus has an opaque plastic arena (30 × 30 cm), and animals could explore freely the entire area. The total distance traveled (cm) was analyzed using Ethovision XT software (Noldus, Information Technology, Leesburg, VA, United States).
Oliveira T.P., Gonçalves B.D., Oliveira B.S., de Oliveira A.C., Reis H.J., Ferreira C.N., Aguiar D.C., de Miranda A.S., Ribeiro F.M., Vieira E.M., Palotás A, & Vieira L.B. (2021). Negative Modulation of the Metabotropic Glutamate Receptor Type 5 as a Potential Therapeutic Strategy in Obesity and Binge-Like Eating Behavior. Frontiers in Neuroscience, 15, 631311.
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