Serdexmethylphenidate (99.55 % purity) and dexmethylphenidate (99.70 % purity) were kindly provided by Novartis Pharma S.A.E., Cairo, Egypt. Azstarys capsules (batch number R-11052) manufactured by Novartis Pharma S.A.E., Cairo, Egypt, under license from Novartis Consumer Health SA—Switzerland; labeled to contain 52.3 mg of Serdexmethylphenidate and 10.4 mg dexmethylphenidate per capsule. Acetonitrile, dichloroethane and methanol, all of HPLC grade (Sigma-Aldrich, Germany). Hydrochloric acid and Sodium hydroxide, analytical grade (El-Nasr Co., Egypt), were prepared as 0.1N aqueous solutions. Phosphate buffer (pH 5.5) was prepared.
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