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Pher2 y877

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PHER2-Y877 is a phosphospecific antibody that specifically recognizes the phosphorylated tyrosine 877 residue of the HER2/ERBB2 protein. This antibody can be used to detect and quantify the phosphorylation of HER2/ERBB2 at this specific site.

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Lab products found in correlation

Dasatinib, by Selleck Chemicals (2 mentions) Pegfr y1068 d7a5, by Cell Signaling Technology (2 mentions) Her2 erbb2 d8f12, by Cell Signaling Technology (2 mentions) Per s118α 16 j4, by Cell Signaling Technology (2 mentions) C6orf97 antibody, by GeneTex (2 mentions) V5 ma5 15253 antibody, by Thermo Fisher Scientific (2 mentions) Pher2 y1221 1222, by Cell Signaling Technology (2 mentions) Bez235, by Selleck Chemicals (2 mentions) Integrin β1 d2e5, by Cell Signaling Technology (2 mentions) Z 4 hydroxytamoxifen, by Merck Group (2 mentions) Azd8931, by Selleck Chemicals (2 mentions) Pher2y1248, by Cell Signaling Technology (2 mentions) Bcl 2, by Cell Signaling Technology (2 mentions) Rad001, by Selleck Chemicals (1 mentions) Pan akt, by Cell Signaling Technology (1 mentions) Ps6 s240 244, by Cell Signaling Technology (1 mentions) Pakt t308, by Cell Signaling Technology (1 mentions) Antibody against hsc 70, by Santa Cruz Biotechnology (1 mentions) Pakt1 s473, by Cell Signaling Technology (1 mentions) Pakt2 s474, by Cell Signaling Technology (1 mentions)

3 protocols using pher2 y877

1

Comprehensive Signaling Pathway Analysis

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Antibodies against AKT1, AKT2, AKT3, panAKT, pAKT S473, pAKT T308, pAKT1 S473, pAKT2 S474, pS6 S240/244, pGSK3α/β S21/9, pHER2 Y877, S100A4, MMP2, RANK, and CTGF, and secondary HRP-linked antibodies against rabbit or mouse IgG were purchased from Cell Signaling Technology Inc. (Danvers, MA, USA). Antibody against AKT3 was provided by Millipore (Burlington, MA, USA). Antibody against HSC-70 was purchased from Santa Cruz Biotechnology Inc. (Dallas, TX, USA). Antibody against pDDR1/2 Y796/Y740 was provided by R&D systems Inc. (Minneapolis, MN, USA). RAD001 was provided by Selleck Chemicals (Houston, TX, USA) and MK-2206 was obtained from AbMole BioScience Inc. (Houston, TX, USA). Recombinant human TGF-β1 and recombinant human EGF were purchased from PeproTech Inc. (Rocky Hill, NJ, USA).
Hinz N., Baranowsky A., Horn M., Kriegs M., Sibbertsen F., Smit D.J., Clezardin P., Lange T., Schinke T, & Jücker M. (2021). Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis. Cells, 10(2), 430.
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2

Multiplex Signaling Pathway Profiling

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Primary antibodies against pEGFR-Y1068 (D7A5), EGFR, pHER2-Y877, pHER2-Y1221/1222 (6B12), pHER2-Y1248, HER2/ErbB2 (D8F12), pHER3-Y1289 (D1B5), HER3 (D22C5), pMet-Y1234/1235 (D26), Met (D1C2), pER-S118α (16 J4), pERα-S167 (D1A3), ERα (D8H8), pAKT-S473 (D9E), AKT (C67E7), pERK (137F5), ERK (D13E1), pSrc-S416 (D49G4), Src (32G6), Integrin β1(D2E5), and Bcl-2 were purchased from Cell Signaling Technology. GFP antibody and HER2/neu Ab-8 (Clone e2-4001) mouse monoclonal antibody used for IP were obtained from Thermo Fisher. C6orf97 antibody is from GeneTex, V5 (MA5-15253) antibody is from Thermo Fisher, and (Z)-4-Hydroxytamoxifen is from Sigma. Fulvestrant (ICI-182780, ZD 9238), lapatinib (GW572016), dasatinib, BEZ235, and AZD8931 were purchased from Selleckchem. Drugs were resolved in DMSO, diluted in culture medium before use.
Li L., Lin L., Veeraraghavan J., Hu Y., Wang X., Lee S., Tan Y., Schiff R, & Wang X.S. (2020). Therapeutic role of recurrent ESR1-CCDC170 gene fusions in breast cancer endocrine resistance. Breast Cancer Research : BCR, 22, 84.
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3

Investigating Receptor Tyrosine Kinase Signaling

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Primary antibodies against pEGFR-Y1068 (D7A5), EGFR, pHER2-Y877, pHER2-Y1221/1222 (6B12), pHER2-Y1248, HER2/ErbB2 (D8F12), pHER3-Y1289 (D1B5), HER3 (D22C5), pMet-Y1234/1235 (D26), Met (D1C2), pER-S118α (16J4), pERα-S167 (D1A3), ERα (D8H8), pAKT-S473 (D9E), AKT (C67E7), pERK (137F5), ERK (D13E1), pSrc-S416 (D49G4), Src (32G6), Integrin β1(D2E5) and Bcl-2 were purchased from Cell Signaling Technology. GFP antibody and HER2/neu Ab-8 (Clone e2-4001) mouse monoclonal antibody used for IP were obtained from Thermo Fisher. C6orf97 antibody is from GeneTex, V5 (MA5-15253 ) antibody is from Thermo Fisher and (Z)-4-Hydroxytamoxifen is from Sigma. Fulvestrant (ICI-182780, ZD 9238), Lapatinib (GW572016), Dasatinib, BEZ235 and AZD8931 were purchased from Selleckchem, Drugs were resolved in DMSO, diluted in culture medium before use.
Li L., Lin L., Veeraraghavan J., Hu Y., Wang X., Lee S., Tan Y., Schiff R., & Wang X. (2020). Therapeutic role of recurrent ESR1-CCDC170 gene fusions in breast cancer endocrine resistance.
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