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Lipopolysaccharides (lps)

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LPS is a laboratory equipment used for the purification and extraction of lipopolysaccharides (LPS) from Gram-negative bacterial cultures. It serves as a tool for researchers studying the structure, function, and biological activities of LPS, which are important components of bacterial cell walls.

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Lab products found in correlation

Lipopolysaccharides (lps), by Merck Group (2 mentions) Humira, by Abbvie (2 mentions)

2 protocols using lipopolysaccharides (lps)

1

Rhesus Macaque Fetal Inflammatory Response

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The Institutional Animal Care and Use Committee at the University of California, Davis, approved all animal procedures. Normally cycling, adult female Rhesus macaques (Macaca mulatta) that already had a normal pregnancy were time mated. Pregnancy, and its maintenance without complication, was confirmed by ultra-sound and examinations carried at ~GD50, GD80 and before experiments were started. Rare twin pregnancies were excluded. At 132 ± 3 day gestation (about 80% of term gestation), pregnant dams received either saline or 1 mg of LPS (Sigma, St. Louis MO) by ultrasound-guided IA injection. IA administration of LPS or saline was performed in mothers of similar weights and ages with fetuses with similar fetal genders and gestational ages (Supplementary Table S1). Fetuses were surgically delivered 16 h later by cesarean section. Delivered fetuses were euthanized with pentobarbital and tissues collected. There were no spontaneous deaths or preterm labor in the animals. Some pregnant dams were given, in addition to IA LPS, either IL-1RA (Kineret® Sobi, Stockholm, Sweden) or Adalimubab (HUMIRA® AbbVie Chicago, IL), or both, administered subcutaneously and IA before IA LPS (see Supplementary Fig. S8).
Jackson C.M., Demmert M., Mukherjee S., Isaacs T., Thompson R., Chastain C., Gray J., Senthamaraikannan P., Presicce P., Chetal K., Salomonis N., Miller L.A., Jobe A.H., Kallapur S.G., Zacharias W.J., Lewkowich I.P., Deshmukh H, & Chougnet C.A. (2022). A potent myeloid response is rapidly activated in the lungs of premature Rhesus macaques exposed to intra-uterine inflammation. Mucosal Immunology, 15(4), 730-744.
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2

Intraamniotic Lipopolysaccharide Exposure in Rhesus Macaques

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The Institutional Animal Care and Use Committee at the University of California, Davis, approved all animal procedures. Normally cycling, adult female Rhesus macaques (Macaca mulatta) that already had a normal pregnancy were time mated. Pregnancy, and its maintenance without complication, was confirmed by ultra-sound and examinations carried at ~GD50, GD80 and before experiments were started. Rare twin pregnancies were excluded. At 132+3 day gestation (about 80% of term gestation), pregnant dams received either saline or 1mg of LPS (Sigma, St. Louis MO) by ultrasound-guided IA injection. IA administration of LPS or saline was performed in mothers of similar weights and ages with fetuses with similar fetal genders and gestational ages (Table S1). Fetuses were surgically delivered 16 hrs later by cesarean section. Delivered fetuses were euthanized with pentobarbital and tissues collected. There were no spontaneous deaths or preterm labor in the animals. Some pregnant dams were given, in addition to IA LPS, either IL-1RA (Kineret® Sobi, Stockholm, Sweden) or Adalimubab (HUMIRA® AbbVie Chicago, IL), or both, administered subcutaneously and IA before IA LPS (see Fig. S8).
Jackson C.M., Demmert M., Mukherjee S., Isaacs T., Thompson R., Chastain C., Gray J., Senthamaraikannan P., Presicce P., Chetal K., Salomonis N., Miller L.A., Jobe A.H., Kallapur S.G., Zacharias W.J., Lewkowich I.P., Deshmukh H, & Chougnet C.A. (2022). A potent myeloid response is rapidly activated in the lungs of premature Rhesus macaques exposed to intra-uterine inflammation. Mucosal Immunology, 15(4), 730-744.
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