All analytes had a purity greater than 98%. Navtemadlin was purchased from MedChemExpress (Monmouth Junction, NJ), and the stable isotope D6-Navtemadlin was obtained from Moravek (Brea, CA). Authentic Navtemadlin glucuronide reference standard was unavailable. Navtemadlin glucuronide was therefore generated from a human liver microsome experiment using standard methods [12 (link)]. HPLC grade acetonitrile and formic acid were purchased from EMD Chemical Inc. (Billerica, MA). Molecular biological grade dimethyl sulfoxide (DMSO) was purchased from Sigma Aldrich (St. Louis, MO). Deionized water was obtained from Millipore Milli-Q-UF filtration system (Milford, MA). Pooled human liver microsomes and cofactors for the incubations were purchased from Corning (Glendale, AZ). Drug-free sodium EDTA human plasma was purchased from Biological Specialty Company (Colmar, PA, USA).
Navtemadlin
Manufactured by MedChemExpress
Navtemadlin is a lab equipment product offered by MedChemExpress. It is a centrifuge designed for the separation and isolation of various biological samples, such as cells, organelles, and macromolecules. The core function of Navtemadlin is to provide a reliable and efficient means of separating components of a heterogeneous mixture based on their differences in density, size, or other physical properties.
Automatically generated - may contain errors
Lab products found in correlation
Milli q uf filtration system, by Merck Group (1 mentions)
Pooled human liver microsomes, by Corning (1 mentions)
Ionomycin, by Cayman Chemical (1 mentions)
Iberdomide, by MedChemExpress (1 mentions)
Avadomide, by MedChemExpress (1 mentions)
Bay11 7082, by Fujifilm (1 mentions)
Phorbol 12 myristate 13 acetate, by Adipogen (1 mentions)
Z vrpr fmk, by Adipogen (1 mentions)
Lenalidomide, by Cayman Chemical (1 mentions)
Mg132, by MedChemExpress (1 mentions)
Siremadlin, by MedChemExpress (1 mentions)
Idasanutlin, by MedChemExpress (1 mentions)
2 protocols using navtemadlin
1
Quantification of Navtemadlin and Metabolite
2
Synthesis and Procurement of Pharmacological Agents
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FPFT-2216 and pomalidomide were synthesized by Fujimoto Pharmaceutical Group. Avadomide, iberdomide, siremadlin, idasanutlin, navtemadlin, milademetan, and MG-132 were procured from MedChemExpress; Z-VRPR-FMK and phorbol 12-myristate 13-acetate (PMA) were procured from Adipogen Life Sciences. Lenalidomide and ionomycin were obtained from Cayman Chemical, BAY 11-7082 from FUJIFILM Wako Pure Chemical Corporation, and safimaltib from Selleck Chemicals. Rituxan Intravenous Infusion (rituximab) was obtained from Zenyaku Kogyo. Z-VRPR-FMK was dissolved in PBS, and other reagents were dissolved in DMSO. The final DMSO concentration used for in vitro experiments did not exceed 0.25%.
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