Biograph 16 pet scanner

PET was performed using an Eminence B PET scanner (Shimadzu); a spatial resolution was 4.5mm (full width at half maximum) slice thickness was 5.6mm or a Biograph-16 PET scanner (Siemens); a spatial resolution was 4.6mm (full width at half maximum) and slice thickness was 5.1mm. Scanning was performed parallel to the orbitomeatal line of the patients. During a period of fasting, 6 MBq/ kg of 11Cmethionine was injected intravenously over 30 seconds. After obtaining a transmission scan, a 10-minute static scan was begun 20 minutes after injection. PET data were analyzed using the same region of interest (ROI) settings as previously reported. 17 (link) Irregular ROIs were manually placed in the co-registered MRI for each lesion and the contralateral cerebral cortex. ROIs were transferred to the corresponding PET image to calculate the uptake of 11C-methionine. Activity counts were normalized relative to the injected dose per kilogram of patient body weight (standardized uptake value). The mean and max standardized uptake values were calculated by semi-quantitative analysis of 11C-methionine uptake by each lesion. The mean and max lesion-to-normal contralateral brain tissue (L/N) ratios were determined by dividing the tumor standardized uptake value by the mean standardized uptake value of the normal contralateral region of the brain, as previously reported. 17, (link)20 (link)