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Lightspeed vct imaging system

Manufactured by GE Healthcare
Sourced in United States

The LightSpeed VCT imaging system is a computed tomography (CT) scanner developed by GE Healthcare. It is designed to capture high-quality images of the human body. The system utilizes a large-area detector and fast data acquisition to enable rapid scanning and reconstruction of detailed, three-dimensional images.

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4 protocols using lightspeed vct imaging system

1

X-ray Attenuation of Au NR@PAMAM-GX1

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X-ray attenuation property of Au NR@PAMAM-GX1 was performed using a LightSpeed VCT imaging system (GE Medical Systems, Milwaukee, WI, USA) with the parameters of 100 Kv, 80 mA, and a thickness of 0.625 mm. Au NR@PAMAM-GX1 dispersion with series of Au concentration was placed in 0.2 mL Eppendorf tubes for CT imaging. All images were converted to Hounsfield units (HU) through using the built-in software.
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2

Light-Triggered Contrast Agent Imaging

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Firstly, the LTCA solution was placed in a quartz cuvette and irradiated by NIR laser for 10 min at 1 W/cm2. C6 cells were seeded in 25 cm2 flask and allowed to grow to ~80% density. Then, the medium was replaced by 2 mL of fresh medium containing various concentrations of LTCAs (I-: 2, 4, 6, 8, and 10 μM). After incubation with LTCAs for 4 h, the medium was replaced by 1.5 mL of cell lysis reagent. The cell lysis solution was then collected for CT imaging. CT scans were performed using a GE Light Speed VCT imaging system at 80 kV and 100 mA, with a slice thickness of 0.625 mm. As a control group, the LTCA solution without irradiation was also evaluated as in the aforementioned procedure. In vitro light-triggered MRI imaging was determined by 3.0-T clinical MRI scanner system (Siemens, Berlin, Germany) at T1WI and T1 map sequences with TR 15 ms and TE 2.1 ms. The cell sample was prepared as in the aforementioned CT procedure; the incubated concentrations of Gd(III) were 0.06, 0.12, 0.18, 0.24, and 0.3 mM.
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3

Multimodal Imaging of C6 Tumor-Bearing Mice

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C6 tumor-bearing BALB/c nude mice were injected with the LTCA solution (200 μL) through the tail vein. After the injection, the tumor CT images of mice with or without laser irradiation were obtained with GE Light Speed VCT imaging system (80 KV, 100 mA, slice thickness 0.625 mm). The in vivo MRI imaging was also evaluated as in the aforementioned procedure and performed on a 3.0 T clinical MRI scanner system (Siemens) at T1WI, T1 map sequences with TR 15 ms and TE 2.1 ms. FI imaging was conducted with a PerkinElmer IVIS system (PerkinElmer, Inc., Santa Clara, USA). Tumor imaging before irradiation was used as control.
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4

ECG-Gated Cardiac CT for Surgical Planning

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ECG-gated cardiac CT image sets were collected prior to each surgery using a LightSpeed VCT imaging system (GE Medical Systems). Image sets were collected during a breath hold after inspiration (i.e. a halt of the forced respiration system), which corresponds to a ground-truth respiration phase ∅R* = 0.3.
The desired cardiac phase of the image sets was ∅C = 0.7, corresponding to the most common motion-free imaging window during diastole.17 The cardiac phase for each slice in the image sets, as shown in Figure 4, was estimated using image metadata, which included the time each image was collected as well as the time of every detected QRS complex in the ECG. Cardiac phase for each slice was calculated as the proportion of time between successive QRS detections. While 3 of the image sets do have jumps in cardiac phase, the portion of the cardiac cycle ranging from 0.6–0.8 is relatively motion-free.18 Cardiac phase for the entire image volume, ∅C*, was estimated as the average phase of the image slices, and ranged from 0.61 to 0.67. Image sets had an axial slice thickness of 0.63 mm, with in-plane pixel spacing of 0.49 mm.
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