Foxp3egfp cre ert2 mice
Foxp3eGFP-Cre-ERT2 mice are a transgenic mouse line that expresses an enhanced green fluorescent protein (eGFP) and a tamoxifen-inducible Cre recombinase (Cre-ERT2) under the control of the Foxp3 promoter. This allows for the specific labeling and manipulation of Foxp3-expressing regulatory T cells (Tregs) in vivo.
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3 protocols using foxp3egfp cre ert2 mice
Genetic Manipulation of Murine Models
Transgenic Mouse Models for Immunology Research
Foxp3YFP-cre mice (stock number 016959) and Foxp3eGFP-Cre-ERT2 mice (stock number 016961) were purchased from the Jackson Laboratory. Rosa26Stat5b-CA mice were provided by Dr. Alexander Rudensky at Memorial Sloan Kettering Cancer Center (10 (link)). Ogtfl/fl Mice (Jackson Laboratory stock number 004860) were kindly provided by Dr. Xiaoyong Yang at Yale University. All mice were on C57BL/6 background. Mice were free to access water and fed on a regular chow, tamoxifen food (Teklad, TD.130860), or 60% high fat diet (ResearchDiets, D12492) as indicated. All procedures were approved by the Institutional Animal Care and Use Committee at the University of Minnesota. All relevant ethical regulations for animal testing and research were complied with.
Genetic Manipulation of Murine Models
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