Kollidon k12

Manufactured by BASF

Sourced in Germany

Kollidon® K12 is a polyvinylpyrrolidone (PVP) product manufactured by BASF. It is a white to slightly yellowish, hygroscopic, free-flowing powder. Kollidon® K12 has a molecular weight of approximately 2,000 g/mol and is soluble in water, ethanol, and other polar solvents.

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Lab products found in correlation

Sodium chloride (nacl), by Merck Group (1 mentions) Tween 20, by Merck Group (1 mentions) Tween 80, by Merck Group (1 mentions) Span 20, by Merck Group (1 mentions) Propylene glycol, by Samchun (1 mentions) Polyethylene glycol 400, by Junsei (1 mentions) Tegosoft ct, by Evonik (1 mentions) Kolliphor p407, by BASF (1 mentions) Kolliphor hs 15, by BASF (1 mentions) Kollicoat ir, by BASF (1 mentions) Kolliphor p188, by BASF (1 mentions) Peg 6000, by BASF (1 mentions) D α tocopherol polyethylene glycol 1000 succinate tpgs, by BASF (1 mentions) Pearlitol 50 c, by Roquette (1 mentions) Methocel e15, by Dow (1 mentions) Lycoat rs 720, by Roquette (1 mentions) Cleargum co 01, by Roquette (1 mentions)

3 protocols using kollidon k12

Preparation of Celecoxib Formulations

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Celecoxib (CCX, M_w = 381.37 g/mol) and magnesium stearate were purchased from Fagron Nordic A/S (Copenhagen, Denmark). Kollidon K12^® (PVP, M_w = 2000–3000 g/mol) was kindly supplied by BASF (Ludwigshafen, Germany). Sodium chloride (NaCl, M_w= 58.44 g/mol) was purchased from Sigma-Aldrich (St. Louis, MO, USA). All chemicals were used as received.

Hempel N.J., Knopp M.M., Berthelsen R, & Löbmann K. (2020). Convection-Induced vs. Microwave Radiation-Induced in situ Drug Amorphization. Molecules, 25(5), 1068.

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Formulation Ingredients for Topical Applications

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Niacinamide 99.5% (nicotinamide, NAC), hexadecyltrimethylammonium bromide 98.0%, benzalkonium chloride 95.0%, alkyltrimethylammonium bromide 95.0%, dodecylamine 98.0%, cetylpyridinium chloride 98.0%, sodium dodecyl sulfate (SDS) 98.5%, Tween®80 (polysorbate 80), Tween®20 (polysorbate 20), Span®20 (sorbitan laurate), phosphate-buffered saline (PBS pH 7.4) powder, and Strat-M® Membrane (25 mm) were purchased from Sigma-Aldrich Inc. (St. Louis, MO, USA). TEGOSOFT® CT was obtained from Evonik (Essen, Germany). Butylene glycol 99.0% (BG), dipropylene glycol 97.0% (DPG), and propylene glycol 99.0% (PG) were purchased from Samchun Pure Chemical Co., Ltd. (Pyeongtaek, Korea). Polyethylene glycol 400 was purchased from Junsei Chemical Co., Ltd. (Tokyo, Japan). Polyoxyethylene (1 6 0) and polyoxylpropylene (30) glycol (Kolliphor® P188), polyoxyethylene (1 9 6) and polyoxylpropylene (67) glycol (Kolliphor® P407), Polyethylene glycol 6000 (PEG6000), polyvinyl alcohol-polyethylene glycol graft copolymer (Kollicoat® IR), polyvinylpyrrolidone (Kollidon® K12), macrogol 15 hydroxystearate (Kolliphor® HS 15), polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus®), and D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) were obtained from BASF (Ludwigshafen, Germany). PVP/VA S-630 was obtained from ISP Technologies Inc. (Wayne, NJ, USA).

Sohn J.S, & Choi J.S. (2023). Development and evaluation of niacinamide transdermal formulation by artificial membrane permeability. Saudi Pharmaceutical Journal : SPJ, 31(7), 1229-1236.

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Formulation Development of Paracetamol Tablets

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Paracetamol Semi-Fine Powder (Mallinckrodt, Hazelwood, USA) was used as poorly soluble model drug (Granberg and Rasmuson, 1999) . Mannitol 50 C (Pearlitol® 50 C, Roquette Frères, Lestrem, France) was used as highly soluble filler (Rowe et al., 2009) (link). Hydroxypropyl (HP) pea starch (Lycoat® RS 720, Roquette Frères, Lestrem, France), hydroxypropyl methylcellulose (HPMC) E15 (Methocel® E15, Dow Chemical Company, Rheinmünster, Germany), polyvinylpyrrolidone (PVP) K12 (Kollidon® K12, BASF, Ludwigshafen, Germany) and sodium octenyl succinate starch (SOS) CO 01 (Cleargum® CO 01, Roquette Frères, Lestrem, France) were used as binders. For wettability measurements, anhydrous dicalcium phosphate (DCP) (Calipharm® A, Innophos, Chicago Heights, USA) was used as hydrophobic model excipient because of its resistance to hydration (Miyazaki et al., 2008; (link)Yu et al., 2014) (link).
Magnesium stearate (MgSt) (Ligamed® MF-2-V, Peter Greven, Bad Münstereifel, Germany) was used as lubricant during tableting.

Vandevivere L., Denduyver P., Portier C., Häusler O., De Beer T., Vervaet C, & Vanhoorne V. (2022). The effect of binder types on the breakage and drying behavior of granules in a semi-continuous fluid bed dryer after twin screw wet granulation. International journal of pharmaceutics, 614.

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