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Aniline hydrochloride

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Aniline hydrochloride is a chemical compound used as a laboratory reagent. It is a crystalline solid salt formed by the reaction of aniline and hydrochloric acid. Aniline hydrochloride is commonly used in various analytical and synthetic procedures in chemical research and development.

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Lab products found in correlation

Hydrochloric acid (hcl), by Merck Group (3 mentions) 2 aminobenzoic acid, by Merck Group (2 mentions) Ammonium persulfate, by Merck Group (2 mentions) Benzylamine, by Merck Group (1 mentions) Mncl2, by Merck Group (1 mentions) 3 phenyl 1 propylamine, by Merck Group (1 mentions) Ammonium persulfate ap, by Merck Group (1 mentions) Ammonium hydroxide solution, by Merck Group (1 mentions) Phenylhydrazine hydrochloride, by Merck Group (1 mentions) 2 aminobenzaldehyde, by Merck Group (1 mentions) Phenylhydrazine, by Merck Group (1 mentions) 2 4 dinitrophenylhydrazine, by Merck Group (1 mentions) 2 aminobenzonitrile, by Merck Group (1 mentions) 2 acetylpyrrole, by Merck Group (1 mentions) Aniline, by Merck Group (1 mentions) P nitroaniline, by Merck Group (1 mentions) 2 acetylpyridine, by Merck Group (1 mentions) Ammonium hydroxide, by Thermo Fisher Scientific (1 mentions) N methyl pyrrolidone (nmp), by Thermo Fisher Scientific (1 mentions) Formic acid, by Merck Group (1 mentions)

Spelling variants of this product

Aniline (297 citations) Hydrochlorides (2 citations) Reagent-grade aniline hydrochloride (2 citations)

14 protocols using aniline hydrochloride

1

Aniline Exposure Effects on Rat Spleen

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Seven-week old male Sprague-Dawley rats were purchased from Harlan Sprague-Dawley (Indianapolis, IN) and acclimated in a controlled environment animal room (temperature, 22°C; relative humidity, 50%; photoperiod, 12-h light/dark cycle) for 7 days prior to dosing. Twelve animals were randomly divided into 2 groups. One group of 6 rats received 1 mmol/kg/day aniline hydrochloride (~97%; Aldrich, Milwaukee, WI) in 0.5 ml of drinking water by gavage for 7 days, while the other 6 rats (control group) received 0.5 ml of water only (Khan et al. 1997 (link), 2003 (link), Wang et al. 2008 (link), 2010 (link), Wu et al. 2005 (link)).
Choice of dose and duration of exposure was based on earlier studies (Khan et al. 1997 (link), 2003 (link), Wang et al. 2008 (link), 2010 (link), Wu et al. 2005 (link)). The rats were euthanized 24 h following last dose and the spleens were collected, weighed and divided into several portions for use in various analyses. Portions of the spleen were snap-frozen in liquid nitrogen and stored at −80°C for RNA isolation and protein extraction. All animal experiments for this study were conducted in accordance with the guidelines of the National Institutes of Health and were approved by the Institutional Animal Care and Use Committee at the University of Texas Medical Branch.
Wang G., Wang J, & Khan M.F. (2017). Altered miRNA expression in aniline-mediated cell cycle progression in rat spleen. Toxicology mechanisms and methods, 27(7), 511-517.
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2

Aniline Exposure Effects on Rat Spleen

Cited 2 times
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Male Sprague-Dawley rats (~200 g), obtained from Harlan Sprague-Dawley (Indianapolis, IN), were maintained in a controlled environment animal room (temperature, 22°C; relative humidity, 50%; photoperiod, 12-h light/dark cycle) for 7 days prior to the treatments. The animals were randomly divided into two groups of six each. One group of animals received 0.5 mmol/kg/day aniline hydrochloride (~97%; Aldrich, Milwaukee, WI) via drinking water (pH of the solution adjusted to ~ 6.8), while the other group received water only and served as controls [7 (link),8 (link),10 (link)–13 (link),15 (link),16 (link)]. Choice of dose and duration of exposure was based on earlier studies [7 (link),8 (link),10 (link),11 (link),13 (link),15 (link),16 (link)]. After 30 days, the animals were euthanized under nembutal (sodium pentobarbital) anesthesia and the spleens were aseptically removed, weighed and divided into several portions for use in various analyses. Portions of the spleen were snap-frozen in liquid nitrogen and stored at -80°C for RNA isolation and protein extraction. All animal experiments were performed in accordance with the guidelines of the National Institutes of Health and were approved by the Institutional Animal Care and Use Committee at the University of Texas Medical Branch.
Wang J., Wang G, & Khan M.F. (2015). Disorder of G2-M Checkpoint Control in Aniline-Induced Cell Proliferation in Rat Spleen. PLoS ONE, 10(7), e0131457.
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3

Synthesis of Arylammonium Chloride Salts

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Aniline hydrochloride (Sigma-Aldrich;
97%), benzylamine (Sigma-Aldrich, 99%), 2-phenethylamine hydrochloride
(Sigma-Aldrich; ≥98%), and 3-phenyl-1-propylamine (Sigma-Aldrich;
98%) were used as the arylammonium source. Salts of phenylmethylammonium
and phenylpropylammonium chloride were synthesized by mixing the organic
liquid with HCl (Sigma-Aldrich; 2.5 M in EtOH) in ethanol absolute,
resulting in a white powder. The powder was then washed with diethyl
ether (Macron Chemicals) and vacuum-dried overnight.
A 1:2 molar
ratio of MnCl2 (Sigma-Aldrich; ≥99%) and the respective
arylammonium chloride salt was dissolved in absolute ethanol. Single
crystals were grown by slow evaporation of the solvent at 60 °C.
After ∼1 week, single crystals were obtained from solution
as platelets with different colors depending on the organic cation
used.
Septiany L., Tulip D., Chislov M., Baas J, & Blake G.R. (2021). Polar Structure and Two-Dimensional Heisenberg Antiferromagnetic Properties of Arylamine-Based Manganese Chloride Layered Organic–Inorganic Perovskites. Inorganic Chemistry, 60(20), 15151-15158.
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4

Aniline Hydrochloride Electropolymerization

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Aniline hydrochloride
(Sigma-Aldrich, 99%)
was used as a monomer. Ammonium persulfate (APS) (Sigma-Aldrich, 98%)
was used as an oxidant with no further purification. Sodium 1-decanesulfonate
(SDSn) (TCI, 98%) was used as received. HCl aqueous solution and ammonium
hydroxide solution (Sigma-Aldrich) were used as a doping and dedoping
agent, respectively.
Hwang D.K., Song D.M, & Im S.S. (2018). Synthesis of Villi-Structured Polyaniline Sheets Using Organic Single Crystal Surface-Induced Polymerization. ACS Omega, 3(4), 4181-4186.
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5

Analytical Characterization of Organic Compounds

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Analytical grade chemicals, including 2-acetylpyrrole, 2-acetylpyridine, aniline, aniline hydrochloride, aniline sulfate, p-nitroaniline, p-nitroaniline hydrochloride, 2-aminobenzoic acid, 2-aminobenzonitrile, 2-aminobenzaldehyde, phenylhydrazine, phenylhydrazine hydrochloride, 2,4-dinitrophenylhydrazine, dicobalt octacarbonyl (Co2(CO)8), chromium hexacarbonyl (Cr(CO)6), 5% rhodium on an activated alumina (Rh/Al2O3) catalyst (99% purity) and internal standard 2,6-dimethylpyridine (2,6-DMP) were purchased from Sigma Aldrich, St. Louis, MO, USA. Silver nitrate (AgNO3) was purchased from POCH, Warsaw, Poland. Methanol (HPLC grade), dichloromethane (AR grade), hydrochloric acid (AR grade), toluene (AR grade) and sodium sulfate anhydrous (AR grade) were purchased from RCI Labscan, Bangkok, Thailand. Deionized water was obtained from a Nanopure Ultrapure water purification system (Thermo Fisher Scientific Inc., Waltham, MA, USA).
Bennett C., Sriyotai W., Wiratchan S., Semakul N, & Mahatheeranont S. (2022). Determination of 2-Acetyl-1-pyrroline via a Color-Change Reaction Using Chromium Hexacarbonyl. Molecules, 27(12), 3957.
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6

Nylon-6 Pellet Characterization

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Nylon-6 pellets (Ultramid B40 01, viscosity
average MW = 63 kDa) were obtained from BASF Corporation (Michigan,
USA). NMP and ammonium hydroxide were obtained from Fisher Scientific
(Wood Dale, IL, and Arlington, TX, respectively). Aniline hydrochloride,
ammonium persulfate, formic acid, and hydrochloric acid were obtained
from Sigma (St. Louis, MO). All chemicals were used as received.
Thornton B.T., Harrison A., Pham A.L., Castano C.E, & Tang C. (2018). Polyaniline-Functionalized Nanofibers for Colorimetric Detection of HCl Vapor. ACS Omega, 3(3), 3587-3591.
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7

Synthesis of Novel Sulfonated Polymers

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All reagents were purchased from commercial sources and used as received without further purification. Aniline hydrochloride (97%), 2-aminobenzoic acid (99%), 2-aminophenol (97%), 1,3-phenylenediamine (99+%), and 1,3-propane sultone (97%) were bought from Sigma-Aldrich. Ammonium persulfate (98%), and AgNO3 (99%) were bought from Acros Organics. Hydrochloric solution was purchased from Duksan Pure Chemicals Co., Ltd., Korea.
Padmanaban S., Kim M, & Yoon S. (2017). Size-tunable Synthesis of Silver Nanobelts Using a Polyaniline Derived Polymer as a Template. Scientific Reports, 7, 44796.
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8

Cholesterol Homeostasis Modulation Assay

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The following compounds were used: 25-hydroxycholesterol (25HC, Sigma-Aldrich, St. Louis, MO), DAPI (Sigma-Aldrich), aminooxybiotin (Biotium, Fremont, CA), aniline hydrochloride (Sigma-Aldrich), avasimibe (Sigma-Aldrich), cholesterol (Sigma-Aldrich), doxycycline (Sigma-Aldrich), filipin III (Santa Cruz Biotechnology, Dallas, TX), gel filtration markers kit (MWGF1000, Sigma-Aldrich), GGTI 298 trifluoroacetate salt hydrate (Sigma-Aldrich), Hygromycin B Gold (InvivoGen, San Diego, CA), IAA (iodoacetamide, Sigma-Aldrich), lipoprotein-depleted fetal bovine serum (LPDS, Kalen Biomedical, Germantown, MD), LMNG (lauryl maltose neopentyl glycol, Anatrace, Maumee, OH), methyl-β-cyclodextrin (MBCD, Sigma-Aldrich), MG132 (Merck Chemicals Ltd, Darmstadt, Germany), N-ethylmaleamide (NEM, Thermo Fisher Scientific), propidium iodide (Sigma-Aldrich), puromycin (Invivogen), SILAC Lys-8-Arg-10 kit (282986444, Silantes GmbH, Munich, Germany), sodium-meta-periodate (Sigma-Aldrich) and ZA (zaragozic acid A, Santa Cruz Biotechnology).
Volkmar N., Thezenas M.L., Louie S.M., Juszkiewicz S., Nomura D.K., Hegde R.S., Kessler B.M, & Christianson J.C. (2019). The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis. Journal of Cell Science, 132(2), jcs223453.
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9

Electrochemical Analysis of Novel Psychoactive Substances

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Butylone, methylenedioxypyrovalerone (MDPV) and naphyrone, all in forms of hydrochlorides, were acquired by the Forensic Laboratory of Biologically Active Substances (UCT, Prague) from Alfarma s.r.o. 3-Aminobenzoic acid (98%, 3ABA), aniline hydrochloride (97%, Ani) and 2-aminoindane hydrochloride (98%, 2-AI) were obtained from Sigma-Aldrich (USA). Inorganic compounds and acids used for electrochemical measurements were obtained from Lach-Ner or Penta (both Czech Republic, CR). The 0.04 M Britton-Robinson and 0.1 M phosphate buffers were prepared according to the usual protocol from the literature, 28 and the pH was adjusted using solid sodium hydroxide. The solutions were prepared using redistilled water (UCT, Prague).
Shishkanova T.V., Pospíšilová E., Trchová M, & Broncová G. (2024). Zwitterionic oligomers of 3-aminobenzoic acid on screen-printed electrodes: structure, properties and forensic application. The Analyst, 149(4).
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10

Polycaprolactone-based Antimicrobial Hydrogels

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Poly (ε-caprolactone) (PCL) (Mn = 70,000–90,000 g mol−1), aniline hydrochloride (C6H5NH2·HCl, 99%), benzoyl peroxide (BPO, C14H10O4, 95%), 1-methyl-2-pyrrolidinone (NMP), and agar were procured from Sigma-Aldrich (South Korea). Tetrahydrofuran (THF) and sulfuric acid (H2SO4) were purchased from SK Chemicals (South Korea). Crystal Violet was purchased from Samchun Chemicals (South Korea). Luria–Bertani (LB) broth was purchased from BD Difco (UK). All of the chemicals obtained were used as received without further purification. Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) were obtained from the Korean Collection for Type Culture and the Korean Culture Center of Microorganisms, respectively.
Falak S., Shin B.K, & Huh D.S. (2022). Antibacterial Activity of Polyaniline Coated in the Patterned Film Depending on the Surface Morphology and Acidic Dopant. Nanomaterials, 12(7), 1085.
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