All DBT examinations were performed with a wide-angle DBT system (Selenia® Dimensions® Mammography System, Hologic® ) and synthetic two-dimensional images were generated by using the vendor’s reconstruction software (C-View™ software). The synthetic 2D images commonly replace the FFDM for density assessment during the acquisition of a tomosynthesis in order to reduce radiation dose.
Selenia dimensions mammography system
Manufactured by Hologic
Sourced in United States
The Selenia Dimensions mammography system is a digital breast imaging device designed for breast cancer screening and diagnosis. It captures high-quality, three-dimensional images of the breast using advanced tomosynthesis technology. The system's core function is to provide healthcare professionals with detailed visual information to support clinical decision-making.
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Lab products found in correlation
Ultravist 370, by Bayer (1 mentions)
Voluson e8, by GE Healthcare (1 mentions)
Voluson 730 system, by GE Healthcare (1 mentions)
Lorad selenia, by Hologic (1 mentions)
Epiq 5 systems, by Philips (1 mentions)
12 to 18 mhz high frequency linear array transducers, by Philips (1 mentions)
Signa hdxt, by GE Healthcare (1 mentions)
Magnetom skyra, by Siemens (1 mentions)
7 protocols using selenia dimensions mammography system
1
Tomosynthesis Synthetic 2D Imaging
2
Contrast-Enhanced Digital Mammography Protocol
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CEDMs were performed using a Selenia Dimensions mammography system (Hologic, Marlborough, MA). An intravenous injection of 1.5 mL/kg of body weight with an iodine-based contrast material (Ultravist 370, Bayer HealthCare LLC, Whippany, NJ) was administered with an automated bolus injection at a flow rate of 3 mL/s, followed by a 20 mL saline flush. Scanning began about 2 min after the injection, and all 4 standard mammographic views (craniocaudal and mediolateral oblique images of each breast) were obtained in sequence within 5 min. For each CEDM view, 2 acquisitions were performed serially at 26–31 kVp with rhodium and silver (Rh and Ag) filters for low-energy acquisition, and at 45–49 kVp with a copper filter for high-energy acquisition. A recombination algorithm used to subtract the unenhanced breast tissue provided a subtracted image in which only the areas of contrast enhancement were highlighted. All the CEDM views were used for our analysis [27 ]. The radiologists in our department evaluated CEDM images with knowledge of the biopsy results and availability of CI. They reported the presumed extension of the disease, the presence or absence of enhancement in the site of the index lesion, and also indicated the Background Parenchymal Enhancement (BPE) level, evaluated on recombined images, according to the BI-RADS criteria [26 ] for each patient.
3
Mammographic Breast Density Assessment
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Among the 121 subjects, medical records from 56 patients were found to also include mammograms. A breast specialist radiologist who was blind to the study design and results visually interpreted craniocaudal and mediolateral oblique views of these available screening mammograms obtained within 6 months prior to MRI. According to the fifth edition of BI-RADS criteria, MBD was classified into 4 categories: almost entirely fatty, scattered areas of fibroglandular density, heterogeneously dense, and extremely dense.13 All mammograms had been recorded by Selenia Dimensions Mammography System (Hologic Inc., Marlborough, MA, USA) (Figure 1 ).
4
Mammography Imaging Protocols for DBT and FFDM
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A picture archiving and communication system (PACS) and electronic medical records were used to gather radiology reports from our institution. Patients underwent imaging using the same mammography machine for DBT and FFDM (Selenia Dimensions mammography system; Hologic, Bedford, MA, USA), and standard views of cranio-caudal and mediolateral oblique images were obtained sequentially during one session while the breast was compressed in a fixed position. For DBT, 15 projection images along 15 degrees of arc (1 image/degree of arc) were collected, and this image set was reconstructed automatically into 2DSM by a summing and filtering back-projection technique. All images were stored in the PACS. Additional images (e.g., magnification views) were not included in the current study.
5
Comparison of DCIS Imaging Modalities
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This retrospective analysis reviewed the US and mammographic data from 173 patients with DCIS at the University of Cologne -Department of Senology between the years 2007 and 2010. Of the 173 patients, 34 fulfilled the following requirements: unilateral, pure DCIS, no invasive component, no prior breast cancer nor other malignancy, having undergone mammography as well as bilateral breast US evaluation, no prior chemotherapy or radiation therapy. Identifying patient data was only available to the reviewing physician. Surgical techniques included breastconserving surgery (BCS), mastectomy and skin-sparing or subcutaneous mastectomy (SSM). The average patient age was 57.7 years. Both pre-and postmenopausal patients were evaluated. For the purpose of this work, it was considered to be beneficial to patients if tumor size were overestimated rather than underestimated, as this might require revision surgery due to a R1 resection.
Diagnostic equipment. Mammography was performed using a Selenia Dimensions mammography system (Hologic, Bedford, MA, USA). US was performed by personnel qualified to at least DEGUM Level 2 (Deutsche Gesellschaft für Ultraschall in der Medizin e.V.) using Voluson E8 and a Voluson 730 system (GE Healthcare, Little Chalfont, UK).
Diagnostic equipment. Mammography was performed using a Selenia Dimensions mammography system (Hologic, Bedford, MA, USA). US was performed by personnel qualified to at least DEGUM Level 2 (Deutsche Gesellschaft für Ultraschall in der Medizin e.V.) using Voluson E8 and a Voluson 730 system (GE Healthcare, Little Chalfont, UK).
6
Breast Cancer Screening Protocol
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Patients attended the National Health Service Breast Screening Program (NHSBSP) between February 2010 and September 2019 at sites that are part of the OPTIMAM mammography image database (OMI-DB, see supplementary material and Halling-Brown et al. [15 (link)]). The source data are accessible for other research groups. Our manuscript reports new work that has not been undertaken or reported previously using data from this database [16 ]. Patients were eligible for inclusion if they had standard four-view mammography of ‘for presentation’ type and had normal or malignant episode outcomes. Screening episodes were excluded if the mammograms were not from Hologic machines, or if the woman was not 46–74 year at the time of their screening mammogram, or the woman had breast implants. All mammograms were taken using Hologic Lorad Selenia or Hologic Selenia Dimensions Mammography Systems, following requirements for the MIRAI algorithm [17 ].
7
Multimodal Breast Imaging Protocols
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