Mevalonic acid 5 phosphate

Manufactured by Merck Group

Mevalonic acid 5-phosphate is a chemical compound that serves as an important intermediate in the biosynthesis of various isoprenoid compounds, including cholesterol, steroids, and other vital biomolecules. It is a key step in the mevalonate pathway, which is the primary metabolic route for the production of these essential molecules in many organisms.

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Mevalonic acid (25 citations)

2 protocols using mevalonic acid 5 phosphate

Regulating Cholesterol Metabolism and Cell Cycle

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The reagents used and working concentrations were as follows: Nutlin-3 (10 μM, Sigma-Aldrich, catalog #N6287), LG100268 (Sigma-Aldrich, catalog #SML0279), T0901317 (Sigma-Aldrich, catalog #T2320), 25-hydroxycholesterol (1 μg/ml, Santa Cruz Biotechnology, catalog #sc-214091), N-Acetyl-Leucyl-Leucyl-norleucinal (ALLN, 100 μM, Sigma-Aldrich, catalog #A6185), Simvastatin (10 μM, Sigma-Aldrich, catalog #S6196), mevalonic acid 5-phosphate (1 mM, Sigma-Aldrich, catalog #79849), geranylgeranyl pyrophosphate (10 μM, Sigma-Aldrich, catalog #G6025), GGTI-2133 (20 μM, Sigma-Aldrich, catalog #G5294), Palbociclib (500 nM, Selleck Chemicals, catalog #S1116) and Roscovitine (10 μM, Selleck Chemicals, catalog #S1153).

Moon S.H., Huang C.H., Houlihan S.L., Regunath K., Freed-Pastor W.A., Morris JP I.V., Tschaharganeh D.F., Kastenhuber E.R., Barsotti A.M., Culp-Hill R., Xue W., Ho Y.J., Baslan T., Li X., Mayle A., de Stanchina E., Zender L., Tong D.R., D’Alessandro A., Lowe S.W, & Prives C. (2018). p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression. Cell, 176(3), 564-580.e19.

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Aea Peptide Synthesis and Characterization

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Custom made peptide Aedes aegypti AST-C (AeaAST-C) (QIRYRQCYFNPISCF) was provided by Biopetide Co. (San Diego, CA), purified by reverse phase liquid chromatography and assessed to be 98% pure by analytical mass spectrometry and amino acid analysis. Stock of aqueous solutions of AeaAST-C were prepared at a concentration of 10⁻⁵ M and stored in aliquots at −80 °C. Acetate, citrate, pyruvate, acetyl-CoA (ACoA), mevalonic acid (MVA), mevalonic acid 5-phosphate (MevP), mevalonic acid 5-pyrophosphate (MevPP), farnesal (FAL) and 1,2,3-benzenetricarboxylate (BTC) were purchased from Sigma (St. Louis, MO). Farnesyl diphosphate (FPP), farnesol (FOL), farnesoic acid (FA) and methyl farnesoate (MF) were purchased from Echelon Biosciences (Salt Lake city, UT).

Nouzova M., Rivera-Perez C, & Noriega F.G. (2014). Allatostatin-C reversibly blocks the transport of citrate out of the mitochondria and inhibits juvenile hormone synthesis in mosquitoes. Insect biochemistry and molecular biology, 57, 20-26.

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