Bez 235

Manufactured by Active Motif

Sourced in United Kingdom

BEZ-235 is a dual PI3K/mTOR inhibitor. It is a small molecule that inhibits the activity of both phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) pathways.

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Lab products found in correlation

Bkm120, by Active Motif (2 mentions) Givinostat, by Selleck Chemicals (1 mentions) Cantharidin, by Merck Group (1 mentions) Topotecan, by Merck Group (1 mentions) Scriptaid, by Selleck Chemicals (1 mentions) Mgcd0103, by Selleck Chemicals (1 mentions) Cerivastatin, by Merck Group (1 mentions) Camptothecin, by Merck Group (1 mentions) Lbh589, by Selleck Chemicals (1 mentions) Ms 275, by Selleck Chemicals (1 mentions) Norcantharidin, by Merck Group (1 mentions) Byl719, by Active Motif (1 mentions)

2 protocols using bez 235

High-throughput Drug Screening Compounds

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Libraries used for high-throughput drug screening are described in Figure 1. Other compounds used include the HDAC inhibitors SAHA, HNHA, LBH-589, Scriptaid, MS-275, Givinostat, PDX101, LAQ-824 and MGCD0103 (all from Selleck), the PP2A inhibitors Cantharidin and NorCantharidin, the topoisomerase inhibitors Camptothecin and Topotecan (all from Sigma), the HMG CoA reductase inhibitors Cerivastatin (Sigma) and Itavastatin (Sequoia Research Products Ltd. UK), and the PI3K/mTOR inhibitors BEZ-235 and BKM-120 (both from Active Biochem). All inhibitors were dissolved in DMSO to 20 mM, and further diluted to an appropriate final concentration in culture medium at the time of use.

Pei Y., Liu K.W., Wang J., Garancher A., Tao R., Esparza L.A., Maier D.L., Udaka Y.T., Murad N., Morrissy S., Seker-Cin H., Brabetz S., Qi L., Kogiso M., Schubert S., Olson J.M., Cho Y.J., Li X.N., Crawford J.R., Levy M.L., Kool M., Pfister S.M., Taylor M.D, & Wechsler-Reya R.J. (2016). HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-driven Medulloblastoma. Cancer cell, 29(3), 311-323.

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Inhibition of Cellular Pathways

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Inhibitors BKM120 (#A-1108), BEZ235 (#A-1009), BYL719 (#A-1214), and MKK2206 (#A-1206) were purchased from Active Biochem Co. The IKKβ ATP–competitive inhibitor compound A (61 (link)) was manufactured by Bayer Pharmaceuticals.

Thomas C., Henry W., Cuiffo B.G., Collmann A.Y., Marangoni E., Benhamo V., Bhasin M.K., Fan C., Fuhrmann L., Baldwin A.S., Perou C., Vincent-Salomon A., Toker A, & Karnoub A.E. (2017). Pentraxin-3 is a PI3K signaling target that promotes stem cell–like traits in basal-like breast cancers. Science signaling, 10(467), eaah4674.

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