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Discovery mr450 scanner

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The Discovery MR450 scanner is a magnetic resonance imaging (MRI) system designed and manufactured by GE Healthcare. It is a diagnostic imaging device that uses strong magnetic fields and radio waves to generate detailed images of the body's internal structures. The core function of the Discovery MR450 scanner is to capture high-quality MRI scans for medical professionals to analyze and diagnose various health conditions.

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Lab products found in correlation

Achieva 1.5t, by Philips (1 mentions) Gadovist, by Bayer (1 mentions) 1.5 t aera scanner, by Siemens (1 mentions) Multihance, by Bracco (1 mentions) Dotarem, by Guerbet (1 mentions)

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Discovery MR450 (28 citations) MR450 (12 citations) Scanners (2 citations) Discovery MR450 1.5T MRI Scanner (2 citations)

10 protocols using discovery mr450 scanner

1

Placental T2-Weighted MRI Acquisition Protocol

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Single shot fast spin echo (SSFSE) T2-weighted images were acquired on a 1.5T Discovery MR450 scanner (GE Healthcare, Milwaukee, Wisconsin) using an 8-channel surface receiver coil. Two sets of acquisition parameters were used: TE=160ms, TR=1100ms, 4mm slice thickness and 40 to 60 consecutive slices for full placental coverage in either the maternal coronal or axial plane for a final in-plane resolution of 1.64 mm for the first set, and TE=160ms, TR=1100ms, 8mm slice thickness in the maternal coronal plane for a final in-plane resolution of 0.85. No contrast or sedation was used for any of the MRI studies.
Dahdouh S., Andescavage N., Yewale S., Yarish A., Lanham D., Bulas D., du Plessis A.J, & Limperopoulos C. (2017). In vivo placental MRI shape and textural features predict fetal growth restriction and postnatal outcome. Journal of magnetic resonance imaging : JMRI, 47(2), 449-458.
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2

Fetal MRI Protocol for Placenta and Brain

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All MRI scans were performed on a 1.5T Discovery MR450 scanner (GE Healthcare, Milwaukee, Wisconsin) using an 8-channel surface receive coil (USAI, Aurora, OH). Single shot fast spin echo (SSFSE) T2-weighted images were performed as follows: for the placenta, fat suppressed with TE 160ms, TR 1100ms, FOV 420 × 420mm, 4mm slice thickness and 40 to 60 consecutive slices for full placental coverage in the axial plane. For the fetal brain, TE 160ms, TR 1100ms, FOV 320 ×320 mm, 2mm slice thickness and 40 to 60 consecutive slices for full brain coverage in all 3 orthogonal plans (axial, coronal, sagittal). No contrast or sedation was used for any of the imaging studies. Fetal MRI studies were reviewed by an attending pediatric neuroradiologist who was blinded to FGR case versus control status (G.V.). Any abnormalities of brain development, maturation or the presence of dysgenetic or acquired brain lesions were documented.
Andescavage N., duPlessis A., Metzler M., Bulas D., Vezina G., Jacobs M., Iqbal S.N., Baschat A, & Limperopoulos C. (2017). In vivo Assessment of Placental and Brain Volumes in Growth Restricted Fetuses With and Without Fetal Doppler Changes Using Quantitative 3D MRI. Journal of perinatology : official journal of the California Perinatal Association, 37(12), 1278-1284.
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3

Fetal Brain and Placenta MRI Protocol

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All MRI scans were performed on a 1.5T Discovery MR450 scanner (GE Healthcare, Milwaukee, Wisconsin) using an 8-channel surface receive coil (USAI, Aurora, OH). Single shot fast spin echo (SSFSE) T2-weighted images were performed as follows: for the fetal brain, TE 160ms, TR 1100ms, FOV 320 ×320 mm, 2mm slice thickness and 40 to 60 consecutive slices for full brain coverage in all 3 orthogonal plans (axial, coronal, sagittal); for the placenta, fat suppressed with TE 160ms, TR 1100ms, FOV 420 × 420mm, 4mm slice thickness and 40 to 60 consecutive slices for full placental coverage in the axial plane 20 (link). No contrast or sedation was used for any of the imaging studies.
Haribabu B, & Snyderman R. (1993). Identification of additional members of human G-protein-coupled receptor kinase multigene family.. Proceedings of the National Academy of Sciences of the United States of America, 90(20), 9398-9402.
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4

Fetal Brain and Placenta MRI Protocol

Cited 1 time
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All MRI scans were performed on a 1.5T Discovery MR450 scanner (GE Healthcare, Milwaukee, Wisconsin) using an 8-channel surface receive coil (USAI, Aurora, OH). Single shot fast spin echo (SSFSE) T2-weighted images were performed as follows: for the fetal brain, TE 160ms, TR 1100ms, FOV 320 ×320 mm, 2mm slice thickness and 40 to 60 consecutive slices for full brain coverage in all 3 orthogonal plans (axial, coronal, sagittal); for the placenta, fat suppressed with TE 160ms, TR 1100ms, FOV 420 × 420mm, 4mm slice thickness and 40 to 60 consecutive slices for full placental coverage in the axial plane 20 (link). No contrast or sedation was used for any of the imaging studies.
Andescavage N., Bullen T., Liggett M., Barnett S.D., Kapse A., Kapse K., Ahmadzia H., Vezina G., Quistorff J., Lopez C., duPlessis A, & Limperopoulos C. (2022). Impaired in-vivo feto-placental development is associated with neonatal neurobehavioral outcomes. Pediatric research, 93(5), 1276-1284.
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5

Placental and Fetal Brain MRI Protocol

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MRI scans were performed on a 1.5T Discovery MR450 scanner (GE Healthcare, Milwaukee, Wisconsin) using an 8-channel surface receive coil (USAI, Aurora, OH). Single shot fast spin echo (SSFSE) T2-weighted images were performed as follows: for the placenta, fat suppressed with TE 160ms, TR 1100ms, FOV 420 × 420mm, 4mm slice thickness and 40 to 60 consecutive slices for full placental coverage in the axial plane. For the fetal brain, TE 160ms, TR 1100ms, FOV 320 ×320 mm, 2mm slice thickness and 40 to 60 consecutive slices for full brain coverage in all 3 orthogonal plans (axial, coronal, sagittal). No contrast or sedation was used for any of the imaging studies. Fetal MRI studies were reviewed by an attending pediatric neuroradiologist who was blinded to CHD case versus control status. Any abnormalities of brain development, maturation or the presence of dysgenetic or acquired brain lesions were documented.
Andescavage N., Yarish A., Donofrio M., Bulas D., Evangelou I., Vezina G., McCarter R., DuPlessis A, & Limperopoulos C. (2015). 3-D volumetric MRI evaluation of the placenta in fetuses with complex congenital heart disease. Placenta, 36(9), 1024-1030.
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6

Fetal MRI Protocol for Placenta and Brain

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All MRI scans were performed on a 1.5T Discovery MR450 scanner (GE Healthcare, Milwaukee, Wisconsin) using an 8-channel surface receive coil (USAI, Aurora, OH). Single shot fast spin echo (SSFSE) T2-weighted images were performed as follows: for the placenta, fat suppressed with TE 160ms, TR 1100ms, FOV 420 × 420mm, 4mm slice thickness and 40 to 60 consecutive slices for full placental coverage in the axial plane. For the fetal brain, TE 160ms, TR 1100ms, FOV 320 ×320 mm, 2mm slice thickness and 40 to 60 consecutive slices for full brain coverage in all 3 orthogonal plans (axial, coronal, sagittal). No contrast or sedation was used for any of the imaging studies. Fetal MRI studies were reviewed by an attending pediatric neuroradiologist who was blinded to FGR case versus control status (G.V.). Any abnormalities of brain development, maturation or the presence of dysgenetic or acquired brain lesions were documented.
Andescavage N., duPlessis A., Metzler M., Bulas D., Vezina G., Jacobs M., Iqbal S.N., Baschat A, & Limperopoulos C. (2017). In vivo Assessment of Placental and Brain Volumes in Growth Restricted Fetuses With and Without Fetal Doppler Changes Using Quantitative 3D MRI. Journal of perinatology : official journal of the California Perinatal Association, 37(12), 1278-1284.
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7

Longitudinal Structural MRI of Medicated Patients

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16 patients underwent structural MR imaging at the Cambridge Biomedical Campus using a 1.5 T GE Medical Systems Discovery MR450 scanner. Structural MRI scans were collected prior to commencement of treatment and at 27 months (i.e. 3 months after treatment ceased) to avoid any effects of the medication on brain volumes and fluid shifts, given its known anti-hypertensive actions. A T1-weighted 3D Bravo fast spoiled gradient echo (SPGR) image was acquired with repetition time (TR) = 8156 ms, echo time (TE) = 3.18 ms, matrix = 256 × 256, in-plane resolution of 1 × 1 mm, 252 slices of 1 mm thickness, inversion time = 900 ms and flip angle = 9°.
Analysis of the MRI data was performed using Freesurfer v. 6 (stable-v6-beta-20151015). The region of interest (ROI) values was imported into SPSS. A paired t test was used to estimate the changes in volume between the two time-points.
Underwood B.R., Green-Thompson Z.W., Pugh P.J., Lazic S.E., Mason S.L., Griffin J., Jones P.S., Rowe J.B., Rubinsztein D.C, & Barker R.A. (2017). An open-label study to assess the feasibility and tolerability of rilmenidine for the treatment of Huntington’s disease. Journal of Neurology, 264(12), 2457-2463.
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8

Comprehensive Cardiac MRI Protocol

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CMR studies were performed with a 1.5-T Discovery MR450 scanner (GE Healthcare, Milwaukee, Wisconsin) in center A. In center B, a 1.5-T CVi scanner (GE Healthcare, Milwaukee, Wisconsin), a 1.5-T Achieva (Philips Medical Systems, Best, Netherlands) or a 1.5-T Aera scanner (Siemens, Erlangen, Germany) were used. Dedicated cardiac software, phased array surface receiver coils, and electrocardiogram triggering were used. Breath-hold steady-state free precession cine imaging was performed in vertical and horizontal long-axis orientations and in short-axis orientations. A stack of shortaxis slices encompassing the right and left ventricle from base to apex was used for biventricular volumes, mass, and systolic function assessment. For detecting myocardial brosis, we used a contrastenhanced, breath-hold, segmented T1-weighted inversion-recovery gradient-echo sequence with the LGE technique (i.e., LGE imaging). LGE imaging was performed 10 to 20 min after an intravenous bolus of 0.1 mmol/kg of gadolinium-BOPTA (Multihance, Bracco, Milan, Italy), 0.2 mmol/kg of gadolinium-DOTA (Dotarem, Guerbet, Roissy, France), or 0.2 mmol/kg of Gadobutrol (Gadovist, Bayer AG, Basel, Switzerland). Inversion time was individually adapted to null the signal of remote myocardium (usual range between 220 and 300 ms).
Mushtaq S., Monti L., Rossi A., Pontone G., Conte E., Nicoli F., di Odoardo L., Guglielmo M., Indolfi E., Bombace S., Baggiano A., Gripari P., Pepi M., Bartorelli A., Oliveira M., Santos A., Francone M, & Andreini D. (2023). The prognostic role of right ventricular dysfunction in patients with hypertrophic cardiomyopathy. The international journal of cardiovascular imaging, 39(8).
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9

Placental MRI Imaging Protocol

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All women underwent the same MRI imaging protocol on a 1.5T Discovery MR450 scanner (GE Healthcare, Milwaukee, Wisconsin) using an 8-channel cardiac array (receive only) coil (USAI, Aurora, OH). Pregnant women were positioned in the left lateral or supine position, based on maternal preference for their comfort. The coil array was positioned covering the entire abdomen and pelvis to improve spatial resolution.
Dedicated anatomic single shot fast spin echo (SSFSE) fat suppressed T2-weighted images were acquired in the maternal axial or coronal plane for full placental coverage (TE=160ms, TR=1100ms, 4mm slice thickness). Pulsed gradient spin echo (PGSE) sequences were acquired (TE =53.8 ms, TR=8000 ms, data matrix size 96×96, filed of view (FOV) 420×420mm2, 4mm slice thickness) with the following b-values: 0, 25, 50, 114, 243, 500, 543, 800, 900 sec/mm2, diffusion time=25ms. Each MRI was reviewed by a pediatric radiologist to evaluate for placental malformations.
ANDESCAVAGE N., YOU W., Marni J.A.C.O.B.S., KAPSE K., QUISTORFF J., BULAS D., AHMADZIA H., GIMOVSKY A., BASCHAT A, & LIMPEROPOULOS C. (2020). EXPLORING IN VIVO PLACENTAL MICROSTRUCTURE IN HEALTHY AND GROWTH-RESTRICTED PREGNANCIES THROUGH DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING. Placenta, 93, 113-118.
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10

Fetal Brain Imaging using SSFSE T2

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Multi-plane multi-phase single shot fast spin echo (SSFSE) T2-weighted images for fetal brain were acquired on a 1.5 Tesla GE Discovery MR450 scanner (GE Healthcare, Milwaukee, WI, USA) using an eight-channel surface receiver coil (USAI, Aurora, OH). The following acquisition parameters were used: echo time = 160 ms; repetition time = 1100 ms; field of view = 320 × 320 mm2; matrix = 256 × 256; 2 mm slice thickness and 50 to 70 consecutive slices for full fetal brain coverage in the axial, coronal, and sagittal planes for a final in-plane resolution of 1.25 × 1.25 mm2. Each subject was scanned up to two time points in the fetal period.
Lu Y.C., Andescavage N., Wu Y., Kapse K., Andersen N.R., Quistorff J., Saeed H., Lopez C., Henderson D., Barnett S.D., Vezina G., Wessel D., du Plessis A, & Limperopoulos C. (2022). Maternal psychological distress during the COVID-19 pandemic and structural changes of the human fetal brain. Communications Medicine, 2, 47.
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