32 channel receiver coil

Patients underwent prostate MRI on a 3 T MR750 scanner (GE Healthcare, Waukesha, WI) using a 32-channel receiver coil. Intravenous injection of hyoscine butylbromide (Buscopan, 20 mg/mL; Boehringer, Ingelheim am Rhein, Germany) was administered prior to imaging to reduce peristaltic movement, unless clinically contraindicated. Multiparametric MRI protocol included Axial T₁ and multiplanar high-resolution T₂-weighted 2D fast recovery FSE (field of view (FOV) 18 × 18 cm²; voxel size 0.35 × 0.35 mm²; slice thickness 3 mm; gap 0 mm). Diffusion-weighted imaging (DWI) was performed using a spin-echo echo-planar imaging pulse sequence (FOV 28 cm; slice thickness 3 mm; gap 0 mm; b-values: b-150, b-750, and b-1,400 s/mm²) and an additional small FOV (24 cm) b-2,000 s/mm² DWI sequence; ADC maps were calculated automatically. Dynamic contrast enhancement was performed using a standard sequence (FOV 24 cm; slice thickness and gap 3 mm and 0 mm, respectively; temporal resolution 7 s) following a bolus of Gadobutrol (Gadovist, 0.1 mmol/kg; Bayer, Leverkusen, Germany) at 28 s via a power injector, at a rate of 3 mL/s (dose 0.1 mmol/kg).

All patients underwent prostate MRI on a 3 T MR750 scanner (GE Healthcare) using a 32-channel receiver coil, with the full protocol described in Supplementary Information. At baseline, all patients underwent multiparametric MRI protocol that included multiplanar high-resolution T₂-weighted, diffusion-weighted imaging (DWI), and dynamic contrast-enhanced (DCE) MRI. Follow-up scans were acquired using a biparametric MRI protocol, omitting DCE-MRI.