In order to simulate the patient’s abdomen, a soft silicone phantom with a hard nodule is made. First, Ecoflex 00-20 (Smooth-On, Inc.) is manually mixed in a 1:1 monomer and hardener ratio for 2 mins and placed in the vacuum pump for 20 mins to remove air bubbles. Then, it is cast in a PLA 3D-printed mold. After 24 h, a PLA sphere with a 5 mm diameter is manually placed on top of the cured silicone. Then, more Ecoflex 00-20 is manually mixed in a 1:1 monomer and hardener ratio for 2 mins, while adding silicone pigment (Smooth-On, Inc.) to hide the location of the nodule, and placed in the vacuum pump for 20 mins to remove air bubbles. Lastly, the colored Ecoflex 00-20 is cast so as to entirely cover the PLA nodule and left curing for 24 h. The result is a 25 mm thick square phantom with threaded corners. The different nodule locations for the tests are obtained using a rotating platform on which the phantom is placed.
Ecoflex 00 20
Manufactured by Smooth-On
Sourced in United States
Ecoflex 00-20 is a two-part, platinum-catalyzed silicone rubber that cures at room temperature. It has a Shore 00-20 hardness and provides excellent tensile and tear strength.
Automatically generated - may contain errors
Lab products found in correlation
7 protocols using ecoflex 00 20
1
Soft Silicone Phantom with Hard Nodule
2
Realistic Vocal Pain Expressions with Robotic Phantom
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The overview of the proposed robopatient with vocal pain expressions is depicted in Figure 1 . It mainly consists of three stages: palpation to pain intensity mapping, pain intensity to vocal expression mapping and vocal expression generation, and facial pain expression generations. The developed robopatient is shown in Figure 2 . It contains a force sensor platform, a silicone phantom that mimics the abdomen of a patient, and a robotic face called MorphFace (Lalitharatne et al., 2021 (link)). The silicone phantom is 20 × 20 × 5 cm3 in dimension, and it is fabricated by silicone casting Ecoflex 00-20 (Smooth-On Inc., United States) in a 3D printed PLA mold. The monomer and the crosslinker of the silicone are mixed for 2 min, placed in a vacuum for 20 min, and then, cast and cured into the mold. The excess material has been removed using a scalpel.
3
Soft Bidirectional Actuator for Rapid Motion
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The soft bidirectional actuator (Supplementary Fig. 10d ) consisted of a soft electronic pump, two shrinkable structures and support. The shrinkable structure and support were made of Ecoflex 00-20 (Smooth-on) and silicone 5A, respectively, and fabricated by mould-casting. These parts were aligned and bonded together by applying uncured silicone 5A at their interface and cured for ~3 h at room temperature to form the body of the actuator. About 16-mL liquid was then filled into the chamber by using a syringe with a needle to form the self-contained soft bidirectional actuator. Supplementary Fig. 10d and Supplementary Video 4 demonstrate the rapid bidirectional motion of the soft actuator under the power supply of HVPC, and the response time of the actuator is ~1 s, which is comparable to that of traditional hydraulic and pneumatic systems.
4
Ex Vivo Biological Fistula Model
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The ex vivo biological fistula model was created in the laboratory by adjoining a porcine renal and a carotid artery using a flexible adhesive (Sil-Poxy, Smooth-On). Porcine carotid and renal arteries were purchased from Sierra For Medical Science Inc., California. A defect of 2 mm was created in the renal artery before anastomosing it and bonding it with the carotid artery.
The vascular graft–based fistula model was created by adjoining two vascular grafts (polyester/collagen, Hemashield) with a diameter of 20 and 10 mm using Sil-Poxy (Smooth-On) adhesive. A defect of 2 mm was created in the larger diameter graft before its bonding with the smaller graft. The entire fistula model was coated with a soft silicone elastomer (Ecoflex 00-20, Smooth-On) for sealing purposes, in the absence of blood clotting factors. The vascular fistula defects were closed by the electroceutical catheter with a DC of 3 mA from a Keithley 2450 SourceMeter and subsequently evaluated for tissue sealing.
The vascular graft–based fistula model was created by adjoining two vascular grafts (polyester/collagen, Hemashield) with a diameter of 20 and 10 mm using Sil-Poxy (Smooth-On) adhesive. A defect of 2 mm was created in the larger diameter graft before its bonding with the smaller graft. The entire fistula model was coated with a soft silicone elastomer (Ecoflex 00-20, Smooth-On) for sealing purposes, in the absence of blood clotting factors. The vascular fistula defects were closed by the electroceutical catheter with a DC of 3 mA from a Keithley 2450 SourceMeter and subsequently evaluated for tissue sealing.
5
Simulating Coronary Artery Restenosis
6
Soft, Stretchable Wearable Sensors
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Ecoflex 00–20, Dragon Skin 10, and Dragon Skin 20 were purchased from Smooth-On. Silbione RT Gel 4717 A/B (Silbione) was purchased from Elkem. PI (Kapton, HN100) was purchased from DuPont. PCL was purchased from Polly Plastics. PEDOT:PSS (1.1 % in H2O) was purchased from Sigma–Aldrich. AgNWs (Agnw-40) was purchased from ACS Material. VHB 4910 was purchased from 3 M. Carbon grease was purchased from MG Chemicals. Red dye for marking dots and blue dye for colorizing PCL were purchased from Krylon.
7
Fabrication of Molded Microfluidic Bioreactor Implants
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Sugar molds were sealed with an HRT (319Y-4LS, Nitto) exposing only the mold inlet and a PDMS Oring was placed around the inlet. An Ecoflex mixture (Ecoflex 00-20, Smooth-On) of part A and part B in a 1:1 ratio (w/w) was mixed and degassed using a planetary centrifugal mixer at 2000 rpm for 90 s along with 10% of a silicone thinner (Silicone Thinner, Smooth-On) and .001% of a green silicone pigment (Silc Pig, Smooth-On) by weight. The mixture was quickly placed on ice afterwards and pipetted into the O-ring using a positive displacement pipette. The molds were then placed inside a vacuum desiccator and degassed for 20 min. After venting the desiccator, the Ecoflex prepolymer infilled the molds. The molds were placed in an oven at 60 °C for 1 h. The HRT was removed and the cured MMBIs were released by dissolving the molds in a water bath. MMBIs were then trimmed into 2.5 mm long pieces using a razor blade. For PDMS and silicon implant fabrication process see Figure S2 and S4 of the SI.
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