Td 08811, by Inotiv - Product details

1

High-Fat High-Fructose Diet Diabetes Mouse Model

Cited 2 times

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To generate a diabetes phenotype, mice were placed on a high fat chow and fructose water diet (HFFD). The high fat chow contained 45% calories from fat (TD.08811, Envigo Teklad Custom Diet, UK). Cage water was replaced with a 30% fructose solution (Sigma F0127-5KG). The length of HFFD is specified per given experiment. Chow and water were replaced at 2-week intervals. Male mice were studied due to their susceptibility to diet induced metabolic changes [24 (link)]. Previous metabolic studies found female mice to be more resistant to weight gain, insulin insensitivity and cardiomyopathy [25 (link)].

Chen Y.H., Ta A.P., Chen Y., Lee H.C., Fan W., Chen P.L., Jordan M.C., Roos K.P., MacGregor G.R., Yang Q., Edwards R.A., Li J, & Wang P.H. (2023). Dual roles of myocardial mitochondrial AKT on diabetic cardiomyopathy and whole body metabolism. Cardiovascular Diabetology, 22, 294.

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Dietary Intervention on Aging Mice

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Male 60-day-old C57Bl/6OlaHsd mice were fed ad libitum a high-fat high-sucrose (HFHS) diet (Envigo Teklad diets TD.08811) for 115 days before surgery and 40 days after surgery and then euthanized.

Ben-Haroush Schyr R., Al-Kurd A., Moalem B., Permyakova A., Israeli H., Bardugo A., Arad Y., Hefetz L., Bergel M., Haran A., Azar S., Magenheim I., Tam J., Grinbaum R, & Ben-Zvi D. (2021). Sleeve Gastrectomy Suppresses Hepatic Glucose Production and Increases Hepatic Insulin Clearance Independent of Weight Loss. Diabetes, 70(10), 2289-2298.

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3

High-fat diet study in diversity outbred mice

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DO mice were obtained from the Jackson Laboratory at ~four weeks of age and maintained in the Department of Biochemistry vivarium at the UW-Madison. DO mice were allocated in waves of 100 animals, each with an equal number of males and females. All mice were maintained in a temperature (22.2 °C) and humidity (60%) controlled environment under a 12 h light/dark cycle (lights on at 6:00 and off at 18:00). All mice were fed an HF/HS diet (TD.08811, Envigo Teklad, 44.6% kcal fat, 34% carbohydrate and 17.3% protein) and received sterilized water ad libitum upon arrival at the facility. Mice were kept in the same vivarium room and were individually housed to monitor food intake and prevent cross-inoculation via coprophagy. DO mice were killed at 22–25 weeks of age. Faecal samples were collected immediately before euthanasia after a four h fast. Caecal contents and additional tissues were collected promptly after killing and all samples were immediately flash frozen in liquid nitrogen and stored at −80 °C until further processing. Other studies have been published with these mice^{13 (link),53 (link),65 (link),66 (link)}.

Zhang Q., Linke V., Overmyer K.A., Traeger L.L., Kasahara K., Miller I.J., Manson D.E., Polaske T.J., Kerby R.L., Kemis J.H., Trujillo E.A., Reddy T.R., Russell J.D., Schueler K.L., Stapleton D.S., Rabaglia M.E., Seldin M., Gatti D.M., Keele G.R., Pham D.T., Gerdt J.P., Vivas E.I., Lusis A.J., Keller M.P., Churchill G.A., Blackwell H.E., Broman K.W., Attie A.D., Coon J.J, & Rey F.E. (2023). Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut. Nature Microbiology, 8(3), 424-440.

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4

Germ-free Mice on Western Diet

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C57BL/6J germ-free mice were bred and housed in the gnotobiotic mouse facility at the UW-Madison. Male mice were used for the ornithine lipid study. All mice were maintained in a controlled environment (22.2 °C, 60% humidity) in plastic flexible film gnotobiotic isolators under a strict 12 h light/dark cycle (lights on at 6:00 and off at 18:00) on standard chow diet (LabDiet 5021). At eight weeks of age, mice were switched to a western-style HF/HS diet (44.6% kcal fat, 34% carbohydrate and 17.3% protein) from Envigo Teklad (TD.08811) and orally gavaged with 200 μl of bacterial cultures. At two weeks after colonization, mice were euthanized and caecal contents collected.

Zhang Q., Linke V., Overmyer K.A., Traeger L.L., Kasahara K., Miller I.J., Manson D.E., Polaske T.J., Kerby R.L., Kemis J.H., Trujillo E.A., Reddy T.R., Russell J.D., Schueler K.L., Stapleton D.S., Rabaglia M.E., Seldin M., Gatti D.M., Keele G.R., Pham D.T., Gerdt J.P., Vivas E.I., Lusis A.J., Keller M.P., Churchill G.A., Blackwell H.E., Broman K.W., Attie A.D., Coon J.J, & Rey F.E. (2023). Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut. Nature Microbiology, 8(3), 424-440.

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5

Profiling Atf3 Deficiency in Mice

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Atf3 heterozygous mice (B6.129X1-Atf3^tm1Dron/HaiMmnc) were obtained from the Mutant Mouse Resource and Research Center at University of North Carolina. Age- and sex-matched littermates of Atf3-deficient whole body knockout mice (Atf3^−/−) and WT mice were generated by crossing Atf3 heterozygous mice. Mice were maintained in a controlled environment under a strict 12 h light/dark cycle (lights on at 6:00 and off at 18:00) at 22.2 °C and 60% humidity. Animals were fed an HF/HS diet (TD.08811, Envigo Teklad, 44.6% kcal fat, 34% carbohydrate and 17.3% protein) and received sterilized water ad libitum after weaning. Faecal samples were collected at seven weeks of age.

Zhang Q., Linke V., Overmyer K.A., Traeger L.L., Kasahara K., Miller I.J., Manson D.E., Polaske T.J., Kerby R.L., Kemis J.H., Trujillo E.A., Reddy T.R., Russell J.D., Schueler K.L., Stapleton D.S., Rabaglia M.E., Seldin M., Gatti D.M., Keele G.R., Pham D.T., Gerdt J.P., Vivas E.I., Lusis A.J., Keller M.P., Churchill G.A., Blackwell H.E., Broman K.W., Attie A.D., Coon J.J, & Rey F.E. (2023). Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut. Nature Microbiology, 8(3), 424-440.

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6

High-fat/High-sucrose Diet Impacts on Diverse Outbred Mice

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DO mice were obtained from the Jackson Laboratory at ~four weeks of age and maintained in the Department of Biochemistry vivarium at the UW-Madison. DO mice were allocated in waves of 100 animals, each with an equal number of males and females. All mice were maintained in a temperature (22.2 °C) and humidity (60%) controlled environment under a 12 h light/dark cycle (lights on at 6:00 and off at 18:00). All mice were fed an HF/HS diet (TD.08811, Envigo Teklad, 44.6% kcal fat, 34% carbohydrate and 17.3% protein) and received sterilized water ad libitum upon arrival at the facility. Mice were kept in the same vivarium room and were individually housed to monitor food intake and prevent cross-inoculation via coprophagy. DO mice were killed at 22–25 weeks of age. Faecal samples were collected immediately before euthanasia after a four h fast. Caecal contents and additional tissues were collected promptly after killing and all samples were immediately flash frozen in liquid nitrogen and stored at −80 °C until further processing. Other studies have been published with these mice^{13 (link),53 (link),65 (link),66 (link)}.

Zhang Q., Linke V., Overmyer K.A., Traeger L.L., Kasahara K., Miller I.J., Manson D.E., Polaske T.J., Kerby R.L., Kemis J.H., Trujillo E.A., Reddy T.R., Russell J.D., Schueler K.L., Stapleton D.S., Rabaglia M.E., Seldin M., Gatti D.M., Keele G.R., Pham D.T., Gerdt J.P., Vivas E.I., Lusis A.J., Keller M.P., Churchill G.A., Blackwell H.E., Broman K.W., Attie A.D., Coon J.J, & Rey F.E. (2023). Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut. Nature Microbiology, 8(3), 424-440.

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7

Atf3 Deficiency in High-Fat Diet Mice

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Atf3 heterozygous mice (B6.129X1-Atf3^tm1Dron/HaiMmnc) were obtained from the Mutant Mouse Resource and Research Center at University of North Carolina. Age- and sex-matched littermates of Atf3-deficient whole body knockout mice (Atf3^−/−) and WT mice were generated by crossing Atf3 heterozygous mice. Mice were maintained in a controlled environment under a strict 12 h light/dark cycle (lights on at 6:00 and off at 18:00) at 22.2 °C and 60% humidity. Animals were fed an HF/HS diet (TD.08811, Envigo Teklad, 44.6% kcal fat, 34% carbohydrate and 17.3% protein) and received sterilized water ad libitum after weaning. Faecal samples were collected at seven weeks of age.

Zhang Q., Linke V., Overmyer K.A., Traeger L.L., Kasahara K., Miller I.J., Manson D.E., Polaske T.J., Kerby R.L., Kemis J.H., Trujillo E.A., Reddy T.R., Russell J.D., Schueler K.L., Stapleton D.S., Rabaglia M.E., Seldin M., Gatti D.M., Keele G.R., Pham D.T., Gerdt J.P., Vivas E.I., Lusis A.J., Keller M.P., Churchill G.A., Blackwell H.E., Broman K.W., Attie A.D., Coon J.J, & Rey F.E. (2023). Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut. Nature Microbiology, 8(3), 424-440.

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8

Dietary Impact on Diverse Mice Phenotypes

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We used previously published data from a population of 478 DO mice (Svenson et al. 2012 (link)). DO mice (JAX:DO) are available from The Jackson Laboratory (stock number 009376). The DO population included males and females from DO generations four through 11. Mice were randomly assigned to either a chow diet (6% fat by weight, LabDiet 5K52) or a high-fat, high-sucrose (HF/HS) diet (45% fat, 40% carbohydrates, and 15% protein; Envigo Teklad TD.08811). Mice were maintained on this diet for 26 wk.

Tyler A.L., Spruce C., Kursawe R., Haber A., Ball R.L., Pitman W.A., Fine A.D., Raghupathy N., Walker M., Philip V.M., Baker C.L., Mahoney J.M., Churchill G.A., Trowbridge J.J., Stitzel M.L., Paigen K., Petkov P.M, & Carter G.W. (2023). Variation in histone configurations correlates with gene expression across nine inbred strains of mice. Genome Research, 33(6), 857-871.

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9

Dietary Intervention in Mice

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Mice were housed on a 12 h-light:dark cycle. CC founder strains were obtained from The Jackson Laboratory (Bar Harbor, ME, USA) and were bred at University of Wisconsin, Madison. Mice were group housed by strain (2 mice/cage) and diet under a temperature- and humidity-controlled conditions, and received ad libitum access to water and food. After 4 weeks of age, mice were maintained on either a control (TD.08810, Envigo Teklad, 16.8%-kcal fat, 60.9% carbohydrate, 22.3% protein) or a high-fat high-sucrose diet (TD.08811, Envigo Teklad, 44.6%-kcal fat, 40.6% carbohydrate, 14.8% protein) (Table S1). Strains were housed within the same vivarium throughout the duration of the study.

Kreznar J.H., Keller M.P., Traeger L.L., Rabaglia M.E., Schueler K.L., Stapleton D.S., Zhao W., Vivas E.I., Yandell B.S., Broman A.T., Hagenbuch B., Attie A.D, & Rey F.E. (2017). Host genotype and gut microbiome modulate insulin secretion and diet-induced metabolic phenotypes. Cell reports, 18(7), 1739-1750.

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10

High-fat Diet-induced Obesity in Mice

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Male C57BL/6 mice (Jackson Laboratory, Bar Harbor, Maine) (experiment was repeated three times for the following measures; flow cytometry (n = 10 per group), histology (n = 10 per group) and Concanavalin A n = ~6 per group)), 2–3 months, 27.7±0.22 g) were single housed under controlled conditions (12:12 light-dark cycle, 50%−60% humidity, and 25°C). Mice were allowed 1 week of acclimation prior to experiment start. Mice were given free access to water and a standard CHOW (Harlan Teklad LM485, Madison, WI, USA, 3.1 kcal/g, 18% from fat) or Western high-fat diet (HFD: Harlan Teklad, TD.08811, Madison, WI, USA, 4.7 kcal/g, 45% kcal from fat) until termination at 13 weeks. Bi-weekly measures of body mass and food intake were taken. All procedures underwent review and approval by the Colorado State University Institutional Animal Care and Use Committee.

Magnuson A.M., Regan D.P., Booth A.D., Fouts J.K., Solt C.M., Hill J.L., Dow S.W, & Foster M.T. (2019). High-Fat Diet Induced Central Adiposity (Visceral Fat) is Associated with Increased Fibrosis and Decreased Immune Cellularity of the Mesenteric Lymph Node in Mice. European journal of nutrition, 59(4), 1641-1654.

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Td 08811

Lab products found in correlation

33 protocols using td 08811

High-Fat High-Fructose Diet Diabetes Mouse Model

Dietary Intervention on Aging Mice

High-fat diet study in diversity outbred mice

Germ-free Mice on Western Diet

Profiling Atf3 Deficiency in Mice

High-fat/High-sucrose Diet Impacts on Diverse Outbred Mice

Atf3 Deficiency in High-Fat Diet Mice

Dietary Impact on Diverse Mice Phenotypes

Dietary Intervention in Mice

High-fat Diet-induced Obesity in Mice

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