Plga 75 25

Manufactured by Evonik

Sourced in United States

PLGA 75/25 is a copolymer of polylactic acid (PLA) and polyglycolic acid (PGA) with a 75:25 ratio. It is a biodegradable and biocompatible material commonly used in the production of medical devices and pharmaceutical formulations.

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Lab products found in correlation

Acetonitrile, by Thermo Fisher Scientific (2 mentions) Mille q system, by Merck Group (1 mentions) Hplc grade triethylamine, by Thermo Fisher Scientific (1 mentions) Polyvinyl alcohol (pva), by Kuraray (1 mentions) Plga 50 50, by Evonik (1 mentions)

2 protocols using plga 75 25

Formulation and Characterization of Trehalose-Loaded PLGA Nanoparticles

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GeXIVA[1,2] API was provided by Gill Biochemical Co., Ltd. (Shanghai). PLGA 75/25 was purchased from EVONIK. Trehalose was injection-grade and was purchased from Hayashihara Co., Ltd. (Okayama, Japan). Polyvinyl alcohol (PVA) was purchased from Kuraray co., ltd. HPLC-grade triethylamine and acetonitrile were obtained from Thermo Fisher Scientific (Waltham, MA, USA). The purified water used in this study was prepared using a Mille-Q system (EMD Millipore, Billerica, MA, USA). All other reagents were of analytical grade and were purchased from Sinopharm Chemical Reagent Co., Ltd.

Li L., Li Z., Guo Y., Zhang K., Mi W, & Liu J. (2022). Preparation of uniform-sized GeXIVA[1,2]-loaded PLGA microspheres as long-effective release system with high encapsulation efficiency. Drug Delivery, 29(1), 2283-2295.

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Polymer-Peptide Conjugate Formulation

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Throughout this work the polymers are referred to by their monomer ratio used. For instance, PLGA 75:25 refers to a copolymer consisting of

75 %

lactic acid and

25 %

glycolic acid. Medium-MW (10–25 kDa) PLGA 50:50 and medium-MW (20–30 kDa) PLGA 75:25 were purchased from Evonik Corporation (Birmingham, AL, USA). The exendin-4 peptide (

4.2

kDa) was provided by MedImmune Limited (Cambridge, UK).

Shmool T.A., Hooper P.J., Kaminski Schierle G.S., van der Walle C.F, & Zeitler J.A. (2019). Terahertz Spectroscopy: An Investigation of the Structural Dynamics of Freeze-Dried Poly Lactic-co-glycolic Acid Microspheres. Pharmaceutics, 11(6), 291.

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